Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.6 (
thromboplastin
)
13,278
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
thromboplastin
8139
factor Xa
5162
prothrombin
4735
thrombin
4498
fibrinogen
2136
antithrombin
927
antithrombin III
877
tissue factor
861
Sep
838
factor VIII
785
protein C
505
factor VII
505
thrombin inhibitor
474
factor V
464
VIII
406
collagen
401
Prothrombin
396
tissue factor pathway inhibitor
339
von Willebrand factor
324
plasminogen
322
factor IX
301
PLA
266
hemoglobin
259
protein S
253
serine protease
239
ADP
209
thrombomodulin
178
albumin
175
Mol
173
SDS
170
glycoprotein
168
dilute
167
hemophilia A
166
factor XI
165
tissue plasminogen activator
165
Factor VIII
161
factor XII
156
urokinase-type plasminogen activator
141
She
138
heavy chain
137
FVIII
134
heparin cofactor II
128
plasminogen activator inhibitor
119
kallikrein
117
NMR
114
chymotrypsin
112
lipopolysaccharide
107
polypeptide
104
platelet factor 4
97
plasminogen activator inhibitor-1
95
annexin V
93
bradykinin
91
tumor necrosis factor
90
aspartate aminotransferase
89
alkaline phosphatase
85
C-reactive protein
78
fused
76
alanine aminotransferase
76
membrane-bound
74
serum albumin
73
cytokine
67
trypsin inhibitor
67
X mRNA
66
serine protease inhibitor
64
TNF
64
Antithrombin
63
FIX
63
lactate dehydrogenase
63
factor V Leiden
62
protease inhibitor
62
Protein C
62
EPI
60
coagulation factor VIII
59
GPIIb
56
coagulation factor X
54
P-selectin
53
FDP
53
epidermal growth factor
49
Hageman factor
47
insulin
47
LPS
46
Factor IX
46
alpha 2-plasmin inhibitor
46
Antithrombin III
45
DIC
45
plasma prekallikrein
44
apoE
43
Protein S
43
vWF
43
Pol
43
IL-6
41
Plasminogen
41
vascular endothelium
41
APC
39
coagulation factor V
38
glycoprotein IIb
38
beta-thromboglobulin
38
FXI
38
beta2-glycoprotein I
37
interleukin-6
37
STA
36
phospholipase A2
36
cytochrome P450
35
PCI
35
thrombin receptor
34
platelet-derived
34
esterase
33
protein Z-dependent protease inhibitor
33
ATP
33
Factor XII
33
alpha 1-antitrypsin
32
intrinsic factor
31
PAR-2
31
ACS
31
fibronectin
30
neutrophil elastase
30
P-glycoprotein
30
protein Z
29
HDL
28
creatine kinase
28
ACL
27
cathepsin G
26
chronic renal failure
26
SAR
26
white cell
25
granulocyte
24
Plasmin
23
cage
23
ASA
23
IgA
23
serine proteinase inhibitor
22
ACT
22
Fibrinogen-like protein 2
22
PAR1
22
Thrombomodulin
21
tPA
21
TNF-alpha
21
kit
21
Mal
21
P2Y12
21
glucosamine
21
TAT
20
PAR-1
20
Gen
20
KOP
20
LDH
19
coagulation factor IX
19
arginine vasopressin
19
membrane protein
19
GPI
19
lipoprotein lipase
19
IL-8
19
coagulation factor VII
18
CD62P
18
alpha2-macroglobulin
18
effector cell protease receptor-1
18
Met
18
interferon
18
urinary kallikrein
18
metalloprotease
18
more...
Disease
thrombocytopenia
630
systemic lupus erythematosus
596
stroke
590
disseminated intravascular coagulation
571
lupus
544
coagulopathy
518
lupus
484
deep vein thrombosis
390
cancer
369
haemophilia
325
pulmonary embolism
272
Haemophilia
270
sepsis
197
myocardial infarction
179
SDS
170
sepsis
169
antiphospholipid syndrome
155
tumor
154
anemia
126
von Willebrand disease
122
liver disease
107
hypertension
105
atherosclerosis
100
diabetes
98
acute myocardial infarction
98
Lupus
97
Acquired hemophilia
83
ischemia
81
hemophilia B
80
renal failure
78
Thrombus
73
cirrhosis
72
abortion
67
unstable angina
65
cardiovascular disease
63
renal impairment
62
coronary artery disease
58
hepatitis
58
heart failure
52
plaque
51
carcinoma
51
renal disease
50
autoimmune disease
47
SEM
47
vitamin K deficiency
47
HIV
46
renal insufficiency
45
hemorrhagic diathesis
45
virus infection
45
preeclampsia
44
leukemia
44
cold
44
hepatocellular carcinoma
43
hypofibrinogenemia
41
depression
40
hemolytic anemia
40
obesity
39
myocardial ischemia
39
APC
39
pneumonia
38
coma
38
proteinuria
38
leukopenia
37
hypoprothrombinemia
36
Heparin-induced thrombocytopenia
34
infectious diseases
34
cerebral ischemia
33
multiple myeloma
33
metastases
32
lymphoma
32
acute renal failure
32
coronary thrombosis
32
cerebral infarction
30
chronic renal failure
30
thrombocytosis
30
immunodeficiency
29
respiratory failure
29
dengue
28
coronary heart disease
28
purpura
27
venous stasis
27
vascular disease
26
SAR
26
nephrotic syndrome
26
glomerulonephritis
26
fits
25
syphilis
24
Owren
24
hyperlipidemia
23
pulmonary hypertension
23
vasculitis
23
adenocarcinoma
23
thrombocytopenic purpura
23
breast cancer
22
melanoma
22
chronic liver disease
22
heart disease
22
pancreatitis
22
osteoporosis
21
DVT
21
rare disease
21
lung cancer
21
Thrombophilia
21
acute promyelocytic leukemia
21
adult respiratory distress syndrome
20
SARS
20
peritonitis
20
petechiae
20
rash
20
acute lymphoblastic leukemia
19
arthritis
19
lymphopenia
19
Best
19
hepatitis B
19
cytomegalovirus
19
Brown
19
Rosenthal
19
SLE
19
type 2 diabetes
18
endocarditis
18
viral hepatitis
18
Fibrillation
18
West
18
tumor growth
18
Glanzmann's thrombasthenia
17
Infection
17
transient ischemic attack
16
hypoglycemia
16
rheumatoid arthritis
16
PCC
16
pheochromocytoma
16
hemiparesis
16
Fletcher trait
15
myeloproliferative disorders
15
circulating anticoagulants
15
mole
15
malaria
15
hyperglycemia
15
Alzheimer's disease
15
neutropenia
15
osteoarthritis
15
mole
15
subarachnoid hemorrhage
15
AIDS
15
asthma
14
prostate cancer
14
malnutrition
14
congestive heart failure
14
GSH
14
hypercholesterolemia
14
hemorrhagic fever
14
amyloidosis
14
confusion
14
dysfibrinogenemia
14
platelet disorder
14
MCF
14
thrombophlebitis
13
acute myeloid leukemia
13
leeches
13
sickle cell disease
13
more...
Symptom
anesthesia
131
pain
72
abdominal pain
53
diarrhea
46
vomiting
43
hypothermia
41
dyspnea
37
respiratory distress
35
headache
35
weakness
29
nausea
27
angina
25
fatigue
24
seizures
24
splenomegaly
21
anorexia
20
hepatomegaly
18
chest pain
18
cough
18
lethargy
16
Ill
16
hepatosplenomegaly
15
collapse
15
flushing
15
colic
14
hypoproteinemia
12
myalgia
12
tachypnea
11
pallor
11
livedo
10
analgesia
10
hemoptysis
9
nausea and vomiting
9
dizziness
9
discomfort
8
oliguria
8
discomfort
8
cyanosis
8
chills
8
exhaustion
7
erythema
7
arthralgia
6
hemiplegia
6
tremor
5
sleepiness
5
dysarthria
5
consciousness disturbance
5
paresis
5
overweight
5
exertional dyspnea
4
chorea
4
intestinal bleeding
4
shortness of breath
4
syncope
4
back pain
4
abdominal discomfort
4
HSA
3
low back pain
3
agitation
3
tense
3
constipation
3
paraparesis
3
epigastric pain
3
flank pain
3
paresthesia
3
sore throat
3
ataxia
3
regurgitation
3
functional recovery
2
ENT
2
polydipsia
2
Livedoid
2
menometrorrhagia
2
muscle rigidity
2
Respiratory symptoms
2
spasm
2
spasticity
2
dysuria
2
leg edema
2
presyncope
2
polyuria
2
cachexia
2
irregular bleeding
2
dark urine
2
hyperoxia
2
hypercapnia
2
tonic-clonic seizure
1
Sedation
1
decreased appetite
1
acute pain
1
urinary frequency
1
Organ failure
1
leg pain
1
acute abdominal pain
1
abnormal bruising
1
menopausal symptoms
1
bloating
1
labored breathing
1
non-productive cough
1
pleuritic chest pain
1
apathy
1
shoulder pain
1
CSR
1
epigastric distress
1
distraction
1
stomach pain
1
ovulatory bleeding
1
clonus
1
eds
1
acute abdomen
1
Decreased activity
1
abdominal cramps
1
arm pain
1
not coping
1
numbness
1
Todd's paralysis
1
otalgia
1
acute stress
1
Overlying
1
chronic back pain
1
stridor
1
Visual symptoms
1
Fluctuation
1
right upper quadrant pain
1
Mental status changes
1
fever of unknown origin
1
Urticarial vasculitis
1
Postoperative pain
1
tinnitus
1
loin pain
1
stuffy nose
1
heartburn
1
bradypnea
1
prostration
1
asthenia
1
arm weakness
1
staggering gait
1
acidity
1
chest tightness
1
pelvic pain
1
hip pain
1
twitching
1
hypertonia
1
hypotonia
1
nasal congestion
1
productive cough
1
neck stiffness
1
fussy infant
1
Drug
Cardiovasc
221
Fondaparinux
120
Apixaban
99
Vitamin K
90
lysine
72
CaCl2
64
CaCl2
63
CaCl2
63
PTC
55
LMWH
55
Argatroban
53
Antithrombin III
45
Dalteparin
44
Asn
36
Gel
33
Fragmin
30
EE2
27
Dermatol
26
Ximelagatran
24
ACT
22
ENT
22
TAT
20
RBT
20
uPA
19
nitroglycerin
19
DDAVP
18
PFA
18
Kaolin
17
DDAVP
16
Aprotinin
16
IL-2
15
Norplant
15
NovoSeven
15
Monit
14
Lepirudin
14
Phosphatidylserine
14
Bivalirudin
14
Protamine sulfate
14
Vitamin B12
13
FeCl3
13
Orgaran
13
Lovenox
13
Dial
12
Albumin
12
DFP
12
TAK
12
Clopidogrel
11
lactose
11
Hirulog
11
vitamin E
11
Hydroxyethylstarch
10
Fraction
10
CTX
10
ROC
10
MAP
10
Nephron
9
Norplant
9
EPI
9
Nephron
9
Fragment
8
Ringer's solution
7
Prednisolone
7
Thrombostat
7
Urokinase
7
ascorbate
7
Bayer
6
Coumadin
6
ABC
6
Prednisone
6
Streptokinase
6
Portal
5
Alteplase
5
IFN-gamma
5
EPA
5
Phenprocoumon
5
citric acid
4
Cangrelor
4
Leaf
4
NADH
4
Fluorescein
4
Rituximab
4
AHF
4
CSF
4
Abciximab
4
Alteplase
4
Heparin sodium
4
Alteplase
4
Pentastarch
4
DNase I
4
Fluorescein
4
Glutathione
3
Sodium dehydroacetate
3
Desirudin
3
Ketorolac
3
CFT
3
Ardeparin
3
Desmopressin acetate
3
Biopolymers
3
MgSO4
3
Retinoic acid
3
Isotretinoin
3
Calciparine
3
Levonorgestrel
3
Silica
3
LMOX
3
Serum albumin
3
CAM
3
ampicillin
3
Ancrod
3
Vitamin E
3
Simvastatin
3
Indomethacin
3
CTX
2
Vitamin A
2
CTX
2
Gabexate mesilate
2
Methylprednisolone
2
pyridoxal phosphate
2
ZnO
2
Napsagatran
2
Safflower
2
Itraconazole
2
Dakar
2
caffeine
2
CDP
2
ZnCl2
2
Maltose
2
NH3
2
Warfarin sodium
2
Eptifibatide
2
Iohexol
2
Bromelain
2
ALA
2
Helium
2
KGF
2
Angiotensin II
2
Cilostazol
2
Acacia
2
Nabumetone
2
Ethamsylate
2
Spectrum
2
Rutin
2
Perphenazine
2
ROS
2
Normiflo
2
Iloprost
2
Carbetimer
2
ZnCl2
2
Gamma globulin
1
Ethanol
1
CVA
1
CTC
1
IPD
1
VCR
1
CDX
1
Mezlocillin
1
Clivarine
1
Ketorolac tromethamine
1
Monensin
1
Iopromide
1
more...
Enzyme
thromboplastin
13278
thrombin
4505
APC
817
plasmin
370
trypsin
366
tissue plasminogen activator
297
kallikrein
196
urokinase-type plasminogen activator
150
chymotrypsin
131
alanine aminotransferase
116
aspartate aminotransferase
107
alkaline phosphatase
86
lactate dehydrogenase
75
elastase
64
heparinase
54
phospholipase A2
49
Hageman factor
47
neutrophil elastase
45
creatine kinase
40
mitogen-activated protein kinase
38
tissue kallikrein
35
phospholipase C
32
ACS
31
P-glycoprotein
30
peroxidase
28
ERK
27
papain
27
tryptase
26
cathepsin G
24
glutathione S-transferase
24
subtilisin
22
TAT
20
clotting enzyme
20
beta-galactosidase
19
asparaginase
19
lipoprotein lipase
19
catalase
18
protein kinase
17
protein kinase C
17
superoxide dismutase
17
deaminase
16
AST
15
collagenase
15
ACE
15
thrombin-activatable fibrinolysis inhibitor
14
CYP3A4
14
lipase
14
cancer procoagulant
14
gamma-glutamyl transpeptidase
13
enterokinase
13
acetylcholinesterase
13
phosphodiesterase
12
lysozyme
12
renin
10
neuraminidase
10
coagulation factor VIIa
10
luciferase
10
reverse transcriptase
10
thermolysin
9
cholinesterase
9
ATPase
9
focal adhesion kinase
8
pepsin
8
caspase-3
8
PTA
8
transglutaminase
8
coagulation factor XIa
8
matriptase
7
chymase
7
ceruloplasmin
7
matriptase
7
beta-glucuronidase
6
hyaluronidase
6
apyrase
6
CD10
6
RNase
6
lipoxygenase
6
thromboxane synthase
6
ficin
6
bromelain
6
sorbitol dehydrogenase
6
granzyme B
6
HIV-1 protease
5
dihydrofolate reductase
5
RVV-V
5
CAD
5
proteinase K
5
PNGase F
5
acid phosphatase
5
ancrod
5
CAD
5
CAD
5
ribonuclease
4
coagulation factor IXa
4
endonuclease
4
RNase
4
nucleotidase
4
phenylalanine hydroxylase
4
ribonuclease
4
UDP-glucuronosyltransferase
4
BAL
4
chondroitinase
4
RNA polymerase
4
glutamate dehydrogenase
4
NO synthase
4
thymidine kinase
4
MMP
4
TdT
4
TGT
4
chondroitinase
4
MAP
4
alpha-L-fucosidase
3
heme oxygenase
3
ornithine aminotransferase
3
factor C
3
PAH
3
methylenetetrahydrofolate reductase
3
AMPK
3
proteasome
3
methylenetetrahydrofolate reductase
3
C3 convertase
3
hepsin
3
cathepsin K
3
sialidase
3
5'-nucleotidase
3
caspase-1
3
alcohol oxidase
3
thyroid peroxidase
3
firefly luciferase
3
glutathione peroxidase
3
glutamate dehydrogenase
3
cathepsin B
3
hepsin
3
glutamate dehydrogenase
3
beta-lactamase
3
endoproteinase Glu-C
3
alcohol dehydrogenase
2
beta-secretase
2
S1 nuclease
2
cathepsin D
2
HSD
2
hyaluronidase
2
CPT
2
urease
2
TSR
2
carboxypeptidase B
2
acrosin
2
alpha-galactosidase
2
adenylate cyclase
2
lactic acid dehydrogenase
2
CPT
2
chondroitin ABC lyase
2
C1 esterase
2
cysteine dioxygenase
2
C3 convertase
2
Mg2+-ATPase
2
CPT
2
LPL
2
cathepsin C
2
lysyl endopeptidase
2
more...
Compound
Clin
1135
Dec
924
calcium
693
sulfate
504
Heparin
498
arginine
430
sodium
380
serine
359
Thrombin
347
ADP
310
ADP
215
DNA
211
ADP
209
water
202
creatinine
198
Cardiol
182
SDS
179
Gly
155
lysine
151
Fibrinogen
149
His
144
Warfarin
144
urea
135
glucose
134
alanine
133
Phe
119
oxygen
113
acetate
109
Factor X
103
nitrogen
98
Vitamin K
91
tyrosine
88
Asp
81
EDTA
80
Ile
79
hydrogen
78
cysteine
77
Fibrin
74
ASA
73
galactose
72
phosphate
69
EDTA
68
prostacyclin
68
leucine
67
DEAE
66
CaCl2
64
TNF
64
salt
61
ethanol
58
threonine
57
FDP
53
NH2
52
Argatroban
52
DIC
47
potassium
45
ammonium
44
PEG
43
nitric oxide
43
methionine
42
iron
39
zinc
35
ACS
34
barium
33
ATP
33
ACS
31
Optimal
31
PEG
30
bromide
28
glutamic acid
28
TEM
28
HCl
26
Protamine
26
copper
26
proline
26
glutamine
24
homocysteine
24
acetone
24
Plasmin
23
aspartic acid
23
pyridine
23
acetic acid
23
aspartic acid
22
tryptophan
22
MDA
22
aspartic acid
22
aspartic acid
22
tryptophan
21
tryptophan
21
tryptophan
21
xylose
19
COS
19
MTT
19
vinyl
19
aldehyde
18
acrylic acid
18
sodium chloride
18
prostaglandin E1
18
Dermatan sulfate
18
titanium
17
ammonia
17
Mg2+
17
GSH
17
Organon
17
GSH
17
THP
17
THP
16
Estrogen
16
Serine
16
TEG
16
glutamate
16
Collagen
16
glycerol
16
hydroxide
16
piperidine
15
GalNAc
15
piperidine
15
methanol
15
asparagine
14
Phosphatidylserine
14
guanidine
14
Dextran
14
PMSF
14
C-3
14
Hemoglobin
14
manganese
13
Dermatan sulfate
13
phenol
13
Tris
13
TOF
13
sulfuric acid
12
PLA
12
nickel
12
iodine
12
phosphorus
12
Dial
12
carbonate
12
Trypsin
12
A 3
12
2-naphthyl
12
fluorine
12
TAP
11
valine
11
Heparan sulfate
11
aluminum
11
cAMP
11
Triton X-100
11
SO3
11
aldehyde
11
nitrous acid
11
Tris
11
salicylic acid
10
acrylamide
10
PGE2
10
Salt
10
CO2
10
A 42
10
Tranexamic acid
10
Sodium
10
APAP
10
CTX
10
more...