Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.21.6 (thromboplastin)
 13,278 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Monitoring coagulation parameters during thrombolytic therapy could be useful for prediction and treatment of haemorrhagic episodes. Technology based on dry reagent chemistry has been developed that allows rapid (less than 10 min) assays on small samples of whole blood. The assay principle is based on the restriction of motion of paramagnetic particles during fibrin polymerization, and subsequent liberation of particle motion during fibrinolysis. This technology was used to monitor prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen levels and fibrinolysis profiles during thrombolytic therapy with tissue plasminogen activator for acute myocardial infarction. The PT and aPTT obtained with the COAG-1 correlated well with conventional assays (r = 0.93 and 0.92 for PT and aPTT, respectively; p = 0.0001). Fibrinogen estimates, obtained by COAG-2 also correlated well with modified Clauss assays (r = 0.86, p = 0.0001). The rapid determination of the aPTT may improve management of adjunctive anticoagulant therapy following thrombolysis. The fibrinolysis profile may be useful during thrombolytic therapy to verify that a lytic state has been achieved, to monitor the lytic state throughout therapy, and to verify that the lytic state normalizes once therapy has been completed.
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PMID:Exploration of rapid bedside monitoring of coagulation and fibrinolysis parameters during thrombolytic therapy. 162 19

Perioperative hemorrhage in patients undergoing surgery is a major cause of morbidity and mortality. DRIHEMATO SYSTEM COAG-1 can detect prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) easily. We combined this monitor with platelet count (PLT), activated clotting time (ACT) and thromboelastography (TEG) and devised a hematologic monitoring system for bedside use. This study of 10 adults undergoing cardiopulmonary bypass was conducted to determine the utility of this monitoring system. The specificity for lotting abnormality of this monitoring system included the following values; PT = 88%, FIB = 100% and TEG = 67%. This study suggests that this monitoring system may be useful in early diagnosis and treatment of postoperative coagulopathy.
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PMID:[A hematologic coagulation monitoring system for bedside use]. 899 57

The reproduction and results of Quick's method with tissue thromboplastin (Kirov Institute of Hematology and Blood Transfusion--KIHBT) and Excel and Excel S simplastins (Organon Teknika, Netherlands) in the tube and automated versions were compared. Semiautomated coagulometer COAG-A-MATE XM and automated COAG-A-MATE RA-4 of the same firm were used. Three Verifi plasmas (Organon Teknika) with different activities of factors II, VII, IX, and X were used. Tests with thromboplastin manufactured by KIHBT were well reproduced both in the tube and automated modifications (CV < 10%). This thromboplastin can be used for monitoring the efficiency of therapy by indirect anticoagulants. For evaluating the correlation between results, plasma samples from 21 donors and 12 patients treated by indirect anticoagulants with the prothrombin index (PI) lower than 75% were analyzed. The PI of the tube and automated modifications were in good correlation. Tests with the Russian thromboplastin showed high coefficients of correlation between the two modifications of Quick's test, which recommends the use of these device-reagent combinations for evaluation of PI.
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PMID:[The quality indices of the Quick method using thromboplastin reagents performed manually and instrumentally]. 1087 28