Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.21.6 (thromboplastin)
 13,278 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It was shown in experiments on white rats that combined administration of nucleotide antiaggregants NAD+ and AMP, and NAD+ decomposition inhibitor--nicotinamide, decreased the increment of procoagulant (thromboplastic) activity of membrane particles in the ischemized kidneys and reduced thromboplastic activity of membrane particles in intact kidneys. When nucleotide antiaggregants were added to rabbit citrate plasma, the inhibition by membrane activation of recalcified plasma coagulation was more pronounced with the use of tissue thromboplastin of the kidneys and brain--proteophospholipid liposomes, than with the use of phospholipid liposomes obtained from thromboplastin. The data presented have evidenced an indirect anticoagulant effect of nucleotide aggregants at the level of tissue coagulation factors, and their direct anticoagulant action at the level of membrane activation of plasma factors.
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PMID:[Effect of nucleotide anti-aggregants (NAD, AMP) and ischemia on the tissue blood coagulation factors]. 206 68

The authors studied the influence of adenine and pyridine nucleotides on platelet aggregation and on the time of calcium-induced coagulation of citrate plasma, rich or poor in platelets, with deficiency of membrane fragments and its compensation with exogenous small-dispersed tissue thromboplastin. Calcium ions stimulated the conversion of small-dispersed inactive thromboplastin into a larger and more active substance. The antiaggregation agents AMP and NAD+ inhibited inclusion of phospholipid membrane fragments into the process of recalcified plasma coagulation, i.e. expressed an anticoagulant effect, while the aggregation agents (ADP, NADH) intensified their procoagulant action.
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PMID:[Effect of nucleotide aggregants and anti-aggregants on the coagulation potential of blood plasma]. 270 62