Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.21.6 (thromboplastin)
 13,278 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The natural compounds which affect defensive mechanisms of organism are important in prophylaxis and therapy of diseases in human and animals. Lysozyme is an enzyme which originates from chicken egg proteins. It modulates non-specific and humoral immunological mechanisms. A higher bioactivity has a lysozyme dimmer. The aim of study was assessment of influence of the lysozyme dimmer on chosen blood parameters, morphology and functions of internal organs and healing processes of experimental wounds in rabbits. Lysozyme dimmer (KLP-602) was used obtained process polymerisations enzyme lyzosyme from chicken egg white. The experimental group were on New Zealand White rabbits. Systemic reactions were investigated in animals after two injections of lysozyme dimer in dose 0,02 mg/kg b.w. during 21 days. Blood was collected before and after administration of lysozyme dimer in 4, 6, 24 h and in 3, 7, 21 day after first and in 4, 24 h and 3, 7 day after second injection. The following parameters were evaluated of red blood cells number (RBC), hemoglobin concentration (HGB), haematocrit value (HCT), red blood cell indices (MCV, MCH, MCHC), white blood cells number (WBC) and leukogram. Total serum proteins, components C3 and C4 of complement, immunoglobulins G and M, concentration were determined in the serum. Activated partial thromboplastin time (APTT), prothrombin time (PT) and fibrinogen concentration were evaluated in the plasma. Simultaneously, the activity of alkaline phosphatate, GPT and GOT were assessed. Administration rabbits with lysozyme dimmer caused slight decrease in RBC number, Hb concentration, HCT and the neutrophils percentage and increase in the lymphocytes percentage. The concentrations of TSP, immunoglobulins, the components of complement ware increased too. APTT an PT were normal but the fibrinogen concentration was increased. The activity of GOT and GPT were unchanged. Changes are in range of value normal and step out more quickly after two injection than after firste injection. The morphology of organs (liver, lungs, heart and kidneys) was normal.
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PMID:[The influence of lysozyme dimmer on chosen parameters of blood in healthy rabbits]. 1881 Sep 86

This study examines the effect of the whole seed of Garcinia kola [GKS] on various blood parameters, in adult male albino rats. Five groups, of 6 animals per group, were treated by gavage with suspensions of graded concentrations of GKS daily for 5 weeks. The animals were then sacrificed and blood was obtained for estimation of the data herein presented. Packed red cell volume [PCV], hemoglobin concentration [Hb], and red blood cell count [RBC] showed significantly [P<0.05], increased response to treatment with GKS; while the platelet and white blood cell [WBC] counts showed no corresponding increase with increasing GKS dosage. The mean red blood cell volume [MCV] and mean cell hemoglobin [MCH] levels decreased with increasing GKS dosage. Prothrombin time [PT] and activated partial thromboplastin time [APPT] were both prolonged with increased GKS dosage; while the serum lipids (cholesterol and triglycerides) decreased significantly [P<0.05] with increased GKS dosage.
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PMID:Effect of gavage treatment with pulverised Garcinia kola seeds on erythrocyte membrane integrity and selected haematological indices in male albino Wistar rats. 1982 63