Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.6 (thromboplastin)
 13,278 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In rats of kind of Kruschinskij-Molodkina the number of cells in the stellate ganglion was diminished to 0.5% of the norm after eliminating the sympathetic tonus by means of guanethidine. These animals died of cardiac thrombosis during stress situations. This thrombosis cannot be explained by adrenalin, corticosteroids or thromboplastin spreading in the blood stream. A factor, the nature of which has still to be explained, may be assumed to be responsible for thrombosis to develop during stress situations in animals whose sympathetic tonus has been eliminated by guanethidine.
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PMID:[The reactivity of the anticoagulatory system in sympathectomized animals under stress conditions due to acoustic trauma]. 6 20

Prothrombin (factor II) was assayed in a group of coumarin treated patients using the Echis carinatus venom as thromboplastin. The levels obtained were comparable to those observed using the classical one-stage method. A good correlation was in fact observed between the two methods. The levels observed by the Echis carinatus method were definitely lower than those obtained using two immunological methods indicating that Echis carinatus venom activated, in our system, only normal prothrombin. However, even the levels obtained immunologically were slightly decreased, regardless of the method used, as compared to pooled normal plasma. In congenital prothrombin deficiency (homozygotes and heterozygotes) the level obtained by the Echis carinatus method was comparable to that observed by the one-stage method. On the contrary, in a congenital dysprothrombinemia (prothrombin Padua) a normal level was observed whereas the one-stage and two-stage methods yielded constantly levels of about 50% of normal.
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PMID:The "echis carinatus venom" prothrombin assay in coumarin treated patients. A comparison with one-stage and immunological assays. 6 16

A two stage method to determine prothrombin with the chromogenic peptide substrate benzoyl-phe-val-arg-p-nitroanilide has been worked out. Citrated plasma (10 mul) was diluted in 600 mul tris buffer, pH 8.2, ionic strength 0.18 and activated with 250 mul of a commercial rabbit brain-lung thromboplastin. After 325 s incubation at 37 degrees C 200 mul of a 1 mM solution of the chromogenic substrate was added and the increase in absorbance was recorded in a LKB-Beckman 8600 enzyme analyzer. A reading time of 1 minute (including a delay of 20 s) was used which permitted 55 analyses per hour to be carried out. An approximate linear relationship was found between delta A/min and dilutions of normal plasma in prothrombin deficient plasma. The method is insensitive to variations of factors V, VII and X. Less than 10% or normal plasma was needed to "normalize" plasmas deficient in factor V or VII or X. A group of 99 dicoumarol treated patients and 23 normal subjects has been investigated using the present method and compared with a factor II-VII-X determination method. A correlation coefficient of 0.95 was found.
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PMID:Prothrombin determination by means of a chromogenic peptide substrate. 6 99

Comparisons between British Comparative Thromboplastic (BCT) and a factor II-VII-X determination method--Simplastic A--have been carried out monthly during the time from December 1973 to March 1976. On each occasion fresh plasma from 20 dicoumarol-treated patients was analyzed with the two methods. It was found that the linear regression model is well suited for the comparison, that the BCT thromboplastin did not change significantly during the study, and that the method of comparing has a coefficient of variation of approximately 6-8%. This means, for instance, that a ratio of 3.8 with BCT corresponds to a ratio of 3.5 +/- 0.26 with Simplastin A. Thus in one period you may have ratio 3 and in another ratio 4 as the lower limit of the therapeutic range although you use the same thromboplastin and the same method. The importance of having a stable reference thromboplastin and an established method of comparing thromboplastins is stressed.
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PMID:Comparison between British Comparative Thromboplastin (BCT) and a factor II-VII-X determination method (simplastin A) based on fresh plasma samples from dicoumarol-treated patients. 6 1

The determination of the onset of a disseminated intravascular coagulation (DIC) is examined shortly after its intraoperative andpost-operative dissolution with the help of easily performable haematological and physiological clotting tests in 20 patients. In this connection the operation is appreciated as a model even for other processes defined at the beginning, where DIC can be observed. Whereas the aethanol test, the determination of fibrinogen split products (FSP) and the euglobulin lysis time indicate the beginning of DIC more clearly in the form of average values, the aethanol test, partial thromboplastin time and thrombin time have a prognostic value for each patient. As it is too time consuming to determine FSP, the counting of basophilie granulocytes may be used for the diagnosis. In the initial phase of and post-operative DIC will determine the essential share of predisposition to post-operative thromboembolism.
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PMID:[On the causes of intra- and post-operative consumption coagulopathies and postoperative thromboembolism]. 7 15

An international framework for anticoagulant control has been developed based on British Comparative Thomboplastin (B.C.T.) and the model provided by the British system for anticoagulant control. An alternative international system has been proposed, based on lymphilised thromboplastins prepared at the National Institute of Biological Standards and Control, London. Since 1969, stability studies on two of the N.I.B.S.& C. reagents, the primary material 67/40 and the secondary thromboplastin 69/223, have been in progress at the National (U.K.) Reference Laboratory for Anticoagulant Reagents and Control, Manchester. Both the proposed N.I.B.S.&C. reference preparations have deteriorated, while two lyophilised reagents prepared at the National (U.K.) Reference Laboratory have revealed no evidence of instability. In national and international standardisation reliance on B.C.T. should continue.
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PMID:Stability studies on lyophilised reference thromboplastins for standardisation of prothrombin-times. 7 11

Recent findings of thromboplastin (TRPL) investigations are presented in a brief survey. After enumerating the possibilities of separating this lipoprotein into two shares, the chemical characterization of protein and lipid fraction is represented, the possibilities and conditions of recombining both shares are mentioned and the effectiveness of TRPL in the exogenous coagulation system is illustrated. Furthermore, the liberation of TRPL by leukocytes is referred to and feasible mechanisms of this liberation are discussed. Finally the relations of TRPL to tumour cell materials promoting coagulation and from amnion liquid are discussed.
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PMID:[Thromboplastin. A short review of new findings]. 7 26

The influence of hemofiltration on the number of platelets and on coagulation factors was investigated in patients with chronic renal insufficiency. These investigations were done on 12 patients during 22 treatments with hemofiltration. Blood samples were taken before hemofiltration, 10, 30 and 120 minutes after the beginning of the treatment and at the end of hemofiltration. In comparison to the original values we found a loss of platelets, a small decrease in the concentration of fibrinogen and a small increase in the fibrin monomer complex, plasminogen, antithrombin III, alpha1-antitrypsin and in alpha2-macroglobulin. The thrombin time, the partial thromboplastin time and Quick's test showed that the blood of these patients contained sufficient hepatin. Use of fibrin plates (Astrup) showed no signs of fibrinolytic activity. Compared to the results, which were obtained some years ago during hemodialysis, we found a smaller extent of alterations of blood coagulation factors and number of platelets.
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PMID:Alterations of clotting factors and platelets during hemofiltration. 7 95

20 different adsorbing substances were examined for the purpose of determining physico-chemical parameters influencing the contact activation in the partial thromboplastin time (PTT). In the course of these examinations the prerequisites for the process under way were found to exist in a low adsorbing activity of the substance used as a surface and in the reversibility of adsorption. The effect activating the contact will depend on surface conditions and to a lesser degree on its size. An even crystal structure and the size of particles will have a positive influence on the surface properties and thus on the effect activating the contact.
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PMID:[Activation by means of various adsorbents. (Contribution to the mechanism of contact activation of the blood coagulation process)]. 8 93

In 43 patients with histologically proved hypernephroid kidney cancer evaluation of the electrophoretic results, serum alkaline phosphatase, thromboplastin time (Quick's time) and bromthalein retention (n = 10) was carried out. As a control group the serum values of 10 patients with clinical tentative diagnosis of hypernephroid kidney cancer were checked; in this group operation and histological examination showed no kidney tumor. Only in one patient we found the typical constellation with elevated alkaline phosphatase, diminished albumin, elevated alpha-2 globuline fraction, and decreased thromboplastin time. 10 patients with histologically proved hypernephroid kidney cancer (nephrectomy) did not show any hepatic dysfunctions. Concerning the laboratory findings there was no difference between the two groups. In case of hepatic dysfunctions of unknown etiology a liver punction should be carried out for histologically examination. The cause of hepatic dysfunction (Stauffer syndrome) in cases of hypernephroid kidney cancer are discussed.
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PMID:[The problem of hepatic dysfunction of the diagnosis of hypernephroid kidney carcinomas (Stauffer syndrome)]. 8 2


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