Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.6 (
thromboplastin
)
13,278
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have shown that the drug combination of sulfamethoxazole and trimethoprim has a radio protective effect in mice. Since radiation injury is due in part to microvascular thrombosis produced by the release or action of
thromboplastin
, we evaluated the effect of these drugs individually on
thromboplastin
-accelerated coagulation.
Sulfamethoxazole
at a final concentration of 0.05 microgram/ml and trimethoprim at concentrations of 0.005 and 0.05 microgram/ml significantly prolonged the recalcification times of human plasma. Whether these drugs have an anticoagulant effect when employed clinically remains to be determined.
...
PMID:Beneficial effect of sulfamethoxazole and trimethoprim on accelerated coagulation. 368 79
