Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.6 (thromboplastin)
 13,278 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Drug monitoring for valproic acid (Convulex) was performed in 200 children with a newly developed HPLC procedure and in part with an enzyme immunoassay (EMIT). In addition the activities of the transaminases and the lipase were determined as well as platelet count, prothrombin time, thrombin time, partial thromboplastin time, fibrinogen concentration and in some cases the coagulation factors II, V and X. There is not a higher frequency for pathological laboratory findings with higher serum levels. 81 children exhibited pathological findings, however only in one case therapy had to be stopped. Recommendations when to stop therapy are given.
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PMID:[Drug monitoring for valproic acid with HPLC or EMIT and concomitant measurements of clinical-chemical parameters (author's transl)]. 680 13