Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.6 (
thromboplastin
)
13,278
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Botryosphaeran (
EPS
(FRU)), an exopolysaccharide of the beta-(1-->3,1-->6)-d-glucan type with 31% branching at C-6, is produced by the fungus Botryosphaeria rhodina MAMB-05 when grown on fructose as carbon source. Botryosphaeran was derivatized by sulfonation to induce anticoagulant activity. The effectiveness of the sulfonation reaction by chlorosulfonic acid in pyridine was monitored by the degree of substitution and FT-IR analysis of the sulfonated
EPS
(FRU) (once sulfonated,
EPS
(FRUSULF); and re-sulfonated,
EPS
(FRURESULF)). Activated partial
thromboplastin
time (APTT) and thrombin time (TT) tests of
EPS
(FRURESULF) indicated significant in vitro anticoagulant activity that was dose-dependent.
EPS
(FRU) did not inhibit any of the coagulation tests.
...
PMID:Sulfonation and anticoagulant activity of botryosphaeran from Botryosphaeria rhodina MAMB-05 grown on fructose. 1954 43
