Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.6 (thromboplastin)
 13,278 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Evidence in the literature suggests that von Willebrand's disease constitutes part of a mesenchymal syndrome accompanied by coagulopathy. The cases of two patients with symptomatic intestinal angiodysplasia and concurrent von Willebrand's disease are summarized along with the eight cases previously reported in the literature. All ten cases were in adults ranging in age from 34 to 80 years (average, 58 years). The vascular lesions were located in the stomach or duodenum (four cases), right colon (three cases), and terminal ileum (two cases). One patient had angiodysplasia of the stomach, jejunum, and sigmoid colon. While the prevalence is unknown, these ten cases linking gastrointestinal angiodysplasia with von Willebrand's disease appear to reflect an association greater than more coincidence. Coagulation testing, including determination of template bleeding time and partial thromboplastin time, should probably be performed in all patients bleeding from gastrointestinal angiodysplasia to screen for von Willebrand's disease.
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PMID:Gastrointestinal angiodysplasia: a possible component of von Willebrand's disease. 660 74

A 68-year-old woman with known severe aortic stenosis was admitted to the hospital because of hematochezia and dizziness. She had received several blood transfusions over the preceding 3 years and undergone right hemicolectomy 2 years ago for severe lower gastrointestinal bleeding. Postoperative histology revealed angiodysplasia involving the ascending colon. After the hemicolectomy, she continued to have hematochezia and anemia and required additional blood transfusions for anemia. During this admission, platelet count, activated partial-thromboplastin time, von Willebrand factor antigen, and von Willebrand factor ristocetin cofactor were normal. She had a severe deficiency of high-molecular-weight multimers of von Willebrand factor. Colonoscopy showed angiodysplasia in the transverse colon at this time. Successful coagulation of the bleeding angiodysplasia was achieved by argon plasma coagulator. No additional bleeding was observed thereafter. We report a case of Heyde's syndrome with abnormal von Willebrand factor in a patient who presented with intestinal angiodysplasia and aortic stenosis.
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PMID:[A case of Heyde's syndrome with abnormal von Willebrand factor]. 1497 72