Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.5 (thrombin)
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Human Gene/Protein
CRADD protein 9.9
serum prothrombin conversion accelerator 9.9
ZA protein 9.9
PKC-potentiated PP1 inhibitory protein 9.9
human factor FVIII 9.9
integrator complex subunit 4 9.9
thrombin 9.9
protease-activated receptor 3 9.5
Thrombin receptor 9.4
PAR4 9.3
protease-activated receptor 1 9.2
thrombin receptor 9.2
heparin cofactor II 9.1
Heparin cofactor II 9.1
PAR-1 9.0
protease-activated receptor-1 9.0
FGL2 protein 8.9
Regulator of G-protein signaling 18 8.9
NAT6 8.9
F11R protein 8.9
SERPINE2 protein 8.9
Platelet phospholipase A2 8.9
signalosome subunit 3 8.9
DC33 8.9
thrombin inhibitor 8.9
PAR-4 8.9
factor Xa 8.9
PAR1 8.9
antithrombin 8.8
Thrombomodulin 8.8
effector cell protease receptor-1 8.8
proteinase inhibitor 8 8.7
PAR3 8.6
CHERP 8.6
Antithrombin 8.6
Fibrinopeptide A 8.5
antithrombin III 8.5
thrombomodulin 8.5
thrombin-activatable fibrinolysis inhibitor 8.5
protease-activated receptor 4 8.5
EPR-1 8.4
Coagulation factor V 8.4
Antithrombin-III 8.3
X mRNA 8.3
Flotillin 2 8.3
BARK1 8.3
NBP1 8.3
PN-I 8.3
CTCBF 8.3
FLJ31139 8.3
Protease nexin I 8.3
SPINK9 8.3
FXI 8.1
PAR-3 8.1
3-OST-3 8.1
F2RL2 8.1
coagulation factor I 8.1
PAR2 8.1
Antithrombin III 8.0
platelet phospholipase A2 8.0
tissue factor pathway inhibitor 8.0
Prothrombin 8.0
tissue factor 8.0
alpha 2-plasmin inhibitor 7.9
TM mRNA 7.9
endothelial protein C receptor 7.9
prothrombin 7.9
factor V 7.9
CDK5 protein 7.9
PIP5KIalpha 7.9
plasmin precursor 7.9
Int7 7.9
tubulin-specific chaperone A 7.9
ACTE 7.9
Protein C 7.9
coagulation factor II 7.9
thromboplastin 7.9
nexin 7.8
PAR-2 7.7
protein C 7.7
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Disease
Heparin-induced thrombosis 9.9
retinoblastoma stage 9.9
Factor V inhibition 9.9
Retinal microembolism 9.9
RP34 9.9
Acquired dysfibrinogenemia 9.9
Saddle PE 8.9
Non-rheumatic atrial fibrillation 8.9
Congenital dysfibrinogenemia 8.7
Acute coagulopathy 8.7
HPC4 8.6
HMERF 8.3
Scott syndrome 8.3
dysfibrinogenemia 8.3
Skin hemorrhage 7.9
Livedo vasculitis 7.9
Non-ST elevation myocardial infarction (NSTEMI) 7.9
hereditary factor VII deficiency 7.9
Owren 7.6
Erythrocytopenia 7.6
Generalized atherosclerosis 7.6
Abdominal sepsis 7.5
postperfusion syndrome 7.5
EGMA 7.4
WFS2 7.3
gray syndrome 7.3
hyperheparinemia 7.3
Cavernous lymphangioma 7.3
Heparin-induced thrombocytopenia with thrombosis 7.3
Heparin-induced thrombocytopenia 7.2
Caffeine withdrawal 7.1
von Willebrand disease type 2B 7.1
von Willebrand disease type 2B 7.1
Carotid artery thrombosis 7.1
Glanzmann 7.1
Glanzmann's thrombasthenia 7.0
afibrinogenemia 7.0
Hepatosplenic schistosomiasis 6.9
Transient amnesia 6.9
hypofibrinogenemia 6.8
Postoperative deep vein thrombosis 6.8
Factor XII deficiency 6.8
PC deficiency 6.7
Bernard-Soulier syndrome 6.6
AD6 6.6
thrombopathy 6.6
Severe hemophilia A 6.6
SSS1 6.6
Congenital afibrinogenemia 6.5
Neonatal respiratory distress syndrome 6.5
Thrombophilia 6.5
disseminated intravascular coagulation 6.4
Activated protein C resistance 6.3
Bacteroides infection 6.3
Acute respiratory disease 6.3
Loin pain hematuria syndrome 6.3
hypoprothrombinemia 6.2
Livedoid vasculitis 6.2
circulating anticoagulants 6.2
clotting factor deficiency 6.2
Mural thrombus 6.1
platelet disorder 6.1
Brain Ischemia 6.1
rheumatic endocarditis 6.1
Trousseau's syndrome 6.1
Thrombus 6.0
Takahara 6.0
VVS 6.0
Thromboembolic stroke 6.0
nihilistic delusion 6.0
XDP 5.9
Idiopathic thrombocytopenia 5.9
hemorrhagic diathesis 5.9
coronary thrombosis 5.9
PAF 5.8
Factor VII deficiency 5.8
X-linked hereditary disease 5.8
Essential mixed cryoglobulinemia 5.8
Recurrent pulmonary embolism 5.8
Aortic valve sclerosis 5.8
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Symptom
Easy bruising 6.4
Breast tenderness 5.8
Organ failure 5.5
retrosternal discomfort 4.8
monoplegia 4.7
dacryops 4.7
localized edema 3.2
disturbed balance 3.1
exertional angina 2.9
Signs and Symptoms 2.8
livedo 2.7
intestinal bleeding 2.6
loin pain 2.6
Anoxia 2.4
arm weakness 2.4
bradypnea 2.3
angina 2.2
spasm 2.0
respiratory distress 1.8
autodigestion 1.6
HSA 1.5
hypothermia 1.4
mastalgia 1.3
bladder pain 1.3
Scratch 1.3
colic 1.3
orthopnea 1.1
oliguria 1.1
stomach pain 0.9
syncopal episodes 0.9
arm pain 0.9
microbial colonization 0.9
abdominal cramps 0.8
eds 0.8
Decreased activity 0.8
swollen joints 0.8
cyanosis 0.8
hemoptysis 0.8
hypoproteinemia 0.8
abdominal discomfort 0.7
pleuritic chest pain 0.7
Fluctuation 0.7
presyncope 0.7
chest pain 0.5
collapse 0.5
agitation 0.4
exhaustion 0.4
groin pain 0.3
chest tightness 0.3
menopausal symptoms 0.2
rigors 0.2
consciousness disturbance 0.2
paresis 0.2
functional recovery 0.2
general problem 0.1
splenomegaly 0.1
flushing 0.1
anesthesia 0.0
dysesthesia 0.0
hepatomegaly -0.0
hyperoxia -0.1
chills -0.2
Postoperative pain -0.2
nasal congestion -0.2
epigastric pain -0.3
acute stress -0.3
hot flushes -0.4
ENT -0.5
Sedation -0.5
nasal discharge -0.5
thinning -0.6
hepatosplenomegaly -0.6
discomfort -0.6
skin damage -0.7
acute abdomen -0.7
discomfort -0.8
dyspnea -0.8
acidity -0.8
shortness of breath -0.9
distraction -1.0
more...
Drug
Cyclotheonamide A 9.9
Hirulog 9.5
Desirudin 8.9
Ozagrel sodium 8.9
Batroxobin 8.8
Argatroban 8.8
Chrysalin 8.7
Ximelagatran 8.7
Ancrod 8.5
Bivalirudin 8.4
Lepirudin 8.3
Normiflo 8.3
Ethyl icosapentate 8.3
Warfarin potassium 8.3
Proflavin 8.2
Antithrombin III 8.0
Thrombostat 8.0
Fondaparinux 7.9
Napsagatran 7.9
Clivarine 7.9
Sodium trimetaphosphate 7.9
Orgaran 7.8
Fragmin 7.8
Brinase 7.4
Lysophosphatidylglycerol 7.3
Propylene glycol alginate 7.3
Bromadryl 7.1
Indolidan 7.1
Ardeparin 7.1
Monteplase 7.1
Aggrenox 7.0
Nafamostat mesilate 6.9
Dimetapp 6.9
Protamine sulfate 6.9
Dalteparin 6.9
NovoSeven 6.8
Calciparine 6.8
LMWH 6.7
Halofenate 6.7
Gabexate mesilate 6.7
Apixaban 6.6
Lovenox 6.6
Sulotroban 6.6
Carbetimer 6.6
Cyclandelate 6.5
Eptifibatide 6.5
Ethamsylate 6.4
Diastat 6.4
Hemocoagulase 6.4
CGS 13080 6.4
Abciximab 6.3
Dazoxiben 6.3
Mononine 6.3
Antihemophilic factor 6.2
Z-Pro-Prolinal 6.2
Warfarin sodium 6.1
Aggrastat 6.1
Ozagrel 6.0
Colestimide 5.9
Ridogrel 5.9
Platelet concentrate 5.8
Sulfamide 5.8
Aprotinin 5.7
TAT 5.7
Drotrecogin alfa 5.6
Iloprost 5.6
Drotrecogin alfa 5.6
Vitamin K 5.6
Idursulfase 5.6
Stelazine 5.6
Daltroban 5.6
Pentastarch 5.6
Plavix 5.5
Cangrelor 5.5
Surgicel 5.5
Streptokinase 5.4
Flolan 5.4
Urokinase 5.4
Suloctidil 5.4
Phosphatidylserine 5.4
more...
Enzyme
thrombin 9.9
okinaxobin II 9.9
RVV-V 9.7
nucleoside N-ribosyltransferase 8.9
thrombin-activatable fibrinolysis inhibitor 8.7
coagulation factor IXa 8.5
ancrod 8.5
thromboplastin 8.3
clotting enzyme 8.3
coagulation factor XIa 8.0
glutathione-dependent formaldehyde-activating enzyme 7.9
cancer procoagulant 7.7
plasmin 7.6
atroxase 7.6
C1 esterase 7.3
proteinase yscD 7.1
imidazolonepropionase 7.1
diaminopropionate ammonia-lyase 7.1
coagulation factor VIIa 7.0
endopeptidase I 6.9
APC 6.9
spermosin 6.7
tissue plasminogen activator 6.5
Hageman factor 6.5
kallikrein 6.3
duodenase 6.3
apyrase 6.2
cathepsin G 6.2
carboxypeptidase B 6.1
fibrolase 6.1
TGT 6.0
Ins(1,4,5)P3 3-kinase 6.0
thromboxane synthase 6.0
atrolysin C 6.0
vitamin K epoxidase 6.0
PAF acetyltransferase 6.0
glycoprotease 5.9
tissue kallikrein 5.9
neurosin 5.9
neuropsin 5.8
matriptase 5.7
UDP-N-acetylmuramate:L-alanine ligase 5.7
urokinase-type plasminogen activator 5.7
heparinase 5.7
TAT 5.7
destabilase 5.6
neutrophil elastase 5.6
CPN 5.6
neuropsin 5.6
chondroitin ABC lyase 5.6
chondroitin 4-sulfotransferase 5.4
matriptase 5.4
chymotrypsin 5.4
glycuronidase 5.4
elastase 5.4
hepsin 5.3
hepsin 5.3
tryptase 5.3
GalNAc4S-6ST 5.2
transglutaminase 5.1
myosin light chain kinase 5.1
trypsin 5.1
heparitinase I 5.1
enterokinase 5.0
GP-I 5.0
lysyl endopeptidase 5.0
jararhagin 4.9
12-lipoxygenase 4.9
phospholipase C 4.9
aequorin 4.8
GGTase-I 4.8
Streptomyces griseus protease B 4.7
leucine aminotransferase 4.7
MT 1 4.7
phospholipase A2 4.7
PI-PLC 4.6
LTC4 synthase 4.5
PAF acetyltransferase 4.5
staphopain 4.5
chondroitin synthase 4.5
more...
Compound
1-isopropylpiperidine 9.9
KT-6 9.9
20-OH-LTE4 9.9
Frangulin B 9.9
4-ethylpiperidine 9.9
9-allyl-6-chloro-9H-purine 9.9
Thrombin 9.6
Fibrinopeptide A 8.9
Isotetrandrine 8.9
Tripteroside 8.9
4-(chloromethyl)benzoic acid 8.9
Argatroban 8.8
C6H6N4 8.3
C10H8O2 8.3
13-cis-Retinal 8.3
Diisoeugenol 8.3
2,5,8,11,14-pentaoxapentadecane 8.3
TIPPS 8.3
Denudatin B 7.9
phenylmethanesulfonic acid 7.9
11(R)-HETE 7.9
Trihexosylceramide 7.9
Scolymoside 7.9
nonacosanoic acid 7.9
2,2-diphenyltetrahydrofuran 7.9
NSC 176319 7.9
Factor X 7.9
Benzamidine 7.7
Fibrin 7.7
Dithiodipropionic acid 7.6
Adchnon 7.6
3-morpholinone 7.6
C6H7NO 7.6
N-Acetylimidazole 7.6
2-Hydroxy-5-nitrobenzyl bromide 7.6
4-Chlorobiphenyl 7.6
PGF3alpha 7.6
Fibrinogen 7.5
3-aminophenylalanine 7.4
3,4,9,10-perylenetetracarboxylic acid 7.4
Dermatan sulfate 7.4
Dermatan sulfate 7.3
Ethynodiol diacetate 7.3
Plasmin 7.2
benzenecarboximidamide 7.1
6-ECDCA 7.1
19(S)-HETE 7.1
2-chlorothiophene 6.9
1,2,4,5-benzenetetramine 6.9
hexaric acid 6.9
7H-pyrrolo[3,2-f]quinazoline-1,3-diamine 6.9
Primobolan 6.9
FDP 6.8
p-Bromophenacyl bromide 6.8
Thromboxane B2 6.7
Girinimbine 6.7
C14H12O3 6.7
Adrenic acid 6.7
Heparin 6.6
8-quinolinyl 6.6
L-Iduronic acid 6.6
A 162 6.6
Isopimpinellin 6.6
Calpeptin 6.6
C 80 6.6
Diisopropyl fluorophosphate 6.6
Kadsurenone 6.5
Polybrene 6.5
Pipecolic acid 6.5
Stelazine 6.4
Aurin 6.4
3-indoleacrylic acid 6.4
diphenyl phosphonate 6.4
Ginkgolide J 6.3
Dicentrine 6.3
4-methylproline 6.3
2,6-dibromopyridine 6.3
Ionophore A23187 6.3
Cryptolepine 6.3
TGT 6.3
more...