Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.5 (
thrombin
)
33,306
document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
thrombin
33120
fibrinogen
5799
prothrombin
3713
collagen
2650
factor Xa
2515
antithrombin
2399
Sep
2296
ADP
2152
thromboplastin
2148
antithrombin III
2115
tissue factor
1640
protein C
1391
thrombomodulin
1075
thrombin inhibitor
1003
Mol
954
von Willebrand factor
942
glycoprotein
940
thrombin receptor
933
PLA
922
plasminogen
877
serine protease
872
factor VIII
723
ATP
677
SDS
621
P-selectin
609
GPIIb
577
urokinase-type plasminogen activator
558
factor V
535
tissue plasminogen activator
520
bradykinin
493
protein S
475
factor VII
454
VIII
453
albumin
445
plasminogen activator inhibitor
433
plasminogen activator inhibitor-1
431
polypeptide
416
chymotrypsin
415
PAR-1
414
fibronectin
408
more...
Disease
cancer
879
stroke
810
disseminated intravascular coagulation
785
thrombocytopenia
689
tumor
650
atherosclerosis
639
SDS
621
myocardial infarction
504
sepsis
483
sepsis
460
deep vein thrombosis
440
coagulopathy
435
diabetes
377
haemophilia
349
hypertension
319
ischemia
296
pulmonary embolism
275
Haemophilia
271
pertussis
263
plaque
263
cardiovascular disease
242
acute myocardial infarction
231
coronary artery disease
226
systemic lupus erythematosus
217
unstable angina
187
PAF
182
lupus
168
myocardial ischemia
154
Thrombus
151
vascular disease
144
Alzheimer's disease
141
lupus
139
cirrhosis
130
tumor growth
120
Glanzmann's thrombasthenia
120
von Willebrand disease
118
melanoma
117
breast cancer
115
leukemia
112
carcinoma
110
more...
Symptom
anesthesia
118
pain
114
angina
104
respiratory distress
74
hypothermia
48
collapse
41
seizures
35
spasm
31
headache
29
chest pain
25
exhaustion
19
dyspnea
17
agitation
17
functional recovery
16
diarrhea
16
discomfort
15
discomfort
15
overweight
13
abdominal pain
11
splenomegaly
11
hemoptysis
11
nausea
10
fatigue
10
acidity
9
weakness
9
tremor
9
HSA
9
starvation
9
analgesia
8
vomiting
8
colic
8
thinning
8
cyanosis
7
paresis
7
flushing
7
livedo
6
erythema
6
hepatomegaly
6
back pain
6
exertional angina
6
more...
Drug
Cardiovasc
467
lysine
327
CaCl2
149
CaCl2
147
CaCl2
147
Antithrombin III
145
Asn
144
TAT
127
Gel
112
Argatroban
107
uPA
84
Fondaparinux
81
Bivalirudin
72
Vitamin K
71
Indomethacin
69
LMWH
60
Ximelagatran
59
PTC
57
Fragment
55
vitamin E
50
Aprotinin
49
Dalteparin
44
MAP
44
Fragmin
43
ascorbate
41
Dermatol
41
Hirulog
41
Ancrod
38
Histamine
38
NovoSeven
37
FeCl3
36
ABC
36
DFP
33
NADH
32
nitroglycerin
32
Batroxobin
30
Nephron
30
Apixaban
30
Dial
30
Phosphatidylserine
29
more...
Enzyme
thrombin
33306
thromboplastin
4505
APC
2009
plasmin
1812
trypsin
1519
tissue plasminogen activator
1062
protein kinase C
901
urokinase-type plasminogen activator
590
phospholipase C
561
mitogen-activated protein kinase
494
kallikrein
491
chymotrypsin
478
elastase
396
phospholipase A2
381
protein kinase
372
glutathione S-transferase
230
neutrophil elastase
206
peroxidase
205
ERK
201
transglutaminase
179
adenylate cyclase
177
phosphodiesterase
150
lipoxygenase
148
cathepsin G
134
focal adhesion kinase
132
TAT
127
lactate dehydrogenase
116
apyrase
115
tryptase
112
ATPase
110
ACS
107
thrombin-activatable fibrinolysis inhibitor
106
collagenase
106
myosin light chain kinase
98
alkaline phosphatase
97
papain
96
superoxide dismutase
95
ancrod
87
MEK
87
guanylate cyclase
81
more...
Compound
calcium
3656
Thrombin
3477
ADP
2729
Dec
2408
ADP
2172
ADP
2153
arginine
1858
Clin
1797
DNA
1396
serine
1351
sodium
1223
sulfate
1148
tyrosine
835
prostacyclin
709
Heparin
680
ATP
678
Phe
656
SDS
656
acetate
648
lysine
617
phosphate
582
Gly
561
Fibrinogen
491
cAMP
477
Fibrin
473
nitric oxide
455
alanine
448
EDTA
423
water
419
Asp
419
oxygen
409
EDTA
393
His
368
Cardiol
361
NH2
350
leucine
342
AMP
323
cysteine
306
threonine
300
glucose
281
more...