Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.5 (thrombin)
 33,306 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
thrombin 33120
fibrinogen 5799
prothrombin 3713
collagen 2650
factor Xa 2515
antithrombin 2399
Sep 2296
ADP 2152
thromboplastin 2148
antithrombin III 2115
tissue factor 1640
protein C 1391
thrombomodulin 1075
thrombin inhibitor 1003
Mol 954
von Willebrand factor 942
glycoprotein 940
thrombin receptor 933
PLA 922
plasminogen 877
serine protease 872
factor VIII 723
ATP 677
SDS 621
P-selectin 609
GPIIb 577
urokinase-type plasminogen activator 558
factor V 535
tissue plasminogen activator 520
bradykinin 493
protein S 475
factor VII 454
VIII 453
albumin 445
plasminogen activator inhibitor 433
plasminogen activator inhibitor-1 431
polypeptide 416
chymotrypsin 415
PAR-1 414
fibronectin 408
heparin cofactor II 393
cytokine 380
kallikrein 356
cyclooxygenase 354
platelet factor 4 339
PAR1 338
tissue factor pathway inhibitor 325
insulin 323
lipopolysaccharide 321
Prothrombin 318
AMP 314
epidermal growth factor 296
phospholipase A2 287
beta-thromboglobulin 277
tumor necrosis factor 275
platelet-derived growth factor 275
glycoprotein IIb 271
vascular endothelium 259
NMR 255
platelet-derived 246
FVIII 244
Rho 241
trypsin inhibitor 239
factor IX 239
Thrombomodulin 236
GPIb 236
Protein C 225
tyrosine kinase 224
heavy chain 216
CD62P 213
factor XI 210
hemoglobin 209
GTP 201
protease-activated receptor-1 198
Factor VIII 198
serum albumin 198
PAR4 187
RhoA 186
IL-6 185
PAF 182
fused 182
p38 180
myosin light chain 178
serine protease inhibitor 177
thrombospondin 173
esterase 170
vascular endothelial growth factor 169
protease-activated receptor 1 168
factor XII 168
nexin 168
myosin 168
PKC 161
TNF 160
calmodulin 160
adenylate cyclase 159
endothelin-1 157
IL-8 155
hemophilia A 155
thrombin-activatable fibrinolysis inhibitor 154
membrane-bound 154
Antithrombin 153
angiotensin II 152
vitronectin 151
glutathione S-transferase 150
PAR-2 150
protease inhibitor 149
annexin V 149
lipoxygenase 147
membrane protein 144
LPS 144
phosphodiesterase 144
G protein-coupled receptor 144
Antithrombin III 143
interleukin-6 142
PDGF 139
glycoprotein VI 138
5-hydroxytryptamine 138
transglutaminase 134
cathepsin G 133
C-reactive protein 133
PAR 132
TAT 132
phospholipase 132
ERK1 130
nitric oxide synthase 128
threonine 127
vasopressin 127
neutrophil elastase 125
TRAP 124
calpain 123
megakaryocyte 122
Plasmin 122
TNF-alpha 120
MAPK 120
mer 119
phosphatase 119
osteopontin 117
FDP 117
lectin 116
membrane glycoprotein 115
alpha-chain 115
Plasminogen 114
Pol 113
PAR2 112
alpha 2-plasmin inhibitor 110
factor XIIIa 109
DIC 108
tPA 107
ACS 107
EGF 106
PAR-4 106
PCI 105
ERK 104
GTPase 104
apyrase 104
ATPase 103
APC 102
FIX 102
Trypsin 100
chemokine 97
more...
Disease
cancer 879
stroke 810
disseminated intravascular coagulation 785
thrombocytopenia 689
tumor 650
atherosclerosis 639
SDS 621
myocardial infarction 504
sepsis 483
sepsis 460
deep vein thrombosis 440
coagulopathy 435
diabetes 377
haemophilia 349
hypertension 319
ischemia 296
pulmonary embolism 275
Haemophilia 271
pertussis 263
plaque 263
cardiovascular disease 242
acute myocardial infarction 231
coronary artery disease 226
systemic lupus erythematosus 217
unstable angina 187
PAF 182
lupus 168
myocardial ischemia 154
Thrombus 151
vascular disease 144
Alzheimer's disease 141
lupus 139
cirrhosis 130
Glanzmann's thrombasthenia 120
tumor growth 120
von Willebrand disease 118
melanoma 117
breast cancer 115
leukemia 112
carcinoma 110
APC 107
SEM 105
liver disease 105
antiphospholipid syndrome 103
tumor progression 97
metastases 97
asthma 95
Heparin-induced thrombocytopenia 93
coronary heart disease 92
obesity 92
cold 91
hepatocellular carcinoma 89
Bernard-Soulier syndrome 85
renal failure 85
thrombocytosis 83
HIV 82
Adhesion 82
dysfibrinogenemia 82
type 2 diabetes 82
preeclampsia 81
multiple myeloma 79
sickle cell disease 79
heart failure 74
depression 74
coronary thrombosis 72
neuroblastoma 69
cerebral ischemia 69
renal disease 66
rheumatoid arthritis 66
NAME 64
brain edema 64
hyperlipidemia 64
hypofibrinogenemia 63
pulmonary hypertension 62
hypercholesterolemia 61
Blocking 58
pulmonary edema 56
mole 55
mole 54
anemia 54
arteriosclerosis 53
adenocarcinoma 53
Thrombophilia 53
infectious diseases 51
arthritis 48
lung cancer 47
pneumonia 47
endocarditis 46
nephrotic syndrome 46
hyperglycemia 46
chronic renal failure 46
acute promyelocytic leukemia 46
proteinuria 45
cerebral infarction 45
vasculitis 44
hepatitis 44
hemophilia B 44
subarachnoid hemorrhage 44
lymphoma 43
GSH 42
multiple sclerosis 42
virus infection 42
hemorrhagic diathesis 41
renal insufficiency 41
pancreatitis 41
acute lymphoblastic leukemia 39
cholera 39
glioma 39
thrombocytopenic purpura 39
SCH 39
leeches 39
prostate cancer 38
glomerulonephritis 38
essential hypertension 38
immunodeficiency 38
heart disease 37
pulmonary fibrosis 37
essential thrombocythemia 37
autoimmune disease 37
thalassemia 36
DIP 35
tumorigenesis 35
abortion 35
SAR 34
uremia 34
Lupus 34
malnutrition 33
uterus 33
Best 33
PPP 32
varices 32
lung carcinoma 32
renal impairment 32
afibrinogenemia 31
platelet disorder 31
fits 31
hyperhomocysteinemia 31
MCF 31
acute renal failure 30
myeloproliferative disorders 30
DVT 30
glioblastoma 29
Evans 29
dengue 29
astrocytoma 29
adult respiratory distress syndrome 29
tumor angiogenesis 29
leukopenia 27
colon cancer 27
congestive heart failure 27
polycythemia vera 27
esophageal varices 27
acute myeloid leukemia 26
erythroleukemia 26
inflammatory bowel disease 26
peritonitis 25
abdominal aortic aneurysm 25
squamous cell carcinoma 25
osteoarthritis 25
venous stasis 25
more...
Symptom
anesthesia 118
pain 114
angina 104
respiratory distress 74
hypothermia 48
collapse 41
seizures 35
spasm 31
headache 29
chest pain 25
exhaustion 19
agitation 17
dyspnea 17
functional recovery 16
diarrhea 16
discomfort 15
discomfort 15
overweight 13
abdominal pain 11
hemoptysis 11
splenomegaly 11
nausea 10
fatigue 10
acidity 9
starvation 9
HSA 9
tremor 9
weakness 9
vomiting 8
analgesia 8
colic 8
thinning 8
paresis 7
cyanosis 7
flushing 7
exertional angina 6
erythema 6
livedo 6
hepatomegaly 6
back pain 6
dizziness 5
intestinal bleeding 5
hyperoxia 5
distraction 5
acute stress 4
ENT 4
chills 4
oliguria 4
monoplegia 3
cough 3
Anoxia 3
arthralgia 3
shortness of breath 3
myalgia 3
hepatosplenomegaly 3
lethargy 3
epigastric pain 3
Organ failure 3
abdominal discomfort 3
neck pain 2
Welt 2
eds 2
sleepiness 2
paresthesia 2
anorexia 2
numbness 2
pelvic pain 2
disturbed balance 2
loin pain 2
hunger 2
hypercapnia 2
acute pain 2
microbial colonization 2
hypoproteinemia 2
menopausal symptoms 2
acute abdomen 2
cachexia 2
skin irritation 1
low back pain 1
swollen joints 1
Postoperative pain 1
cerebellar ataxia 1
mastalgia 1
paraparesis 1
presyncope 1
dysesthesia 1
abdominal cramps 1
orthopnea 1
rigors 1
pleuritic chest pain 1
pallor 1
arm pain 1
groin pain 1
stomach pain 1
tense 1
nasal discharge 1
bladder pain 1
general problem 1
Decreased activity 1
constipation 1
exertional dyspnea 1
dysarthria 1
retrosternal discomfort 1
dysuria 1
Easy bruising 1
Ill 1
consciousness disturbance 1
localized edema 1
Fluctuation 1
blurred vision 1
tachypnea 1
memory loss 1
acute abdominal pain 1
bradypnea 1
heartburn 1
hemiplegia 1
arm weakness 1
dacryops 1
chest tightness 1
vertigo 1
shoulder pain 1
hoarseness 1
Breast tenderness 1
Scratch 1
Sedation 1
skin damage 1
bone pain 1
nasal congestion 1
nausea and vomiting 1
Signs and Symptoms 1
wheezing 1
hot flushes 1
syncopal episodes 1
autodigestion 1
Drug
Cardiovasc 467
lysine 327
CaCl2 149
CaCl2 147
CaCl2 147
Antithrombin III 145
Asn 144
TAT 127
Gel 112
Argatroban 107
uPA 84
Fondaparinux 81
Bivalirudin 72
Vitamin K 71
Indomethacin 69
LMWH 60
Ximelagatran 59
PTC 57
Fragment 55
vitamin E 50
Aprotinin 49
Dalteparin 44
MAP 44
Fragmin 43
Hirulog 41
Dermatol 41
ascorbate 41
Histamine 38
Ancrod 38
NovoSeven 37
FeCl3 36
ABC 36
DFP 33
nitroglycerin 32
NADH 32
Apixaban 30
Dial 30
Batroxobin 30
Nephron 30
Phosphatidylserine 29
ACT 29
Lepirudin 28
Iloprost 27
Albumin 27
Urokinase 27
PFA 27
Clopidogrel 26
Streptokinase 26
Abciximab 26
Ethanol 25
CSF 24
Vitamin B12 23
Leaf 22
DNase I 22
ROS 21
IFN-gamma 21
DDAVP 21
Forskolin 20
DDAVP 20
ETA 19
Monit 18
Thrombostat 18
Orgaran 17
Biopolymers 16
Fraction 16
Nephron 16
Gelatin 15
Gelfoam 15
Protamine sulfate 15
Angiotensin II 15
ROC 14
CTA 13
IL-2 13
EPA 13
caffeine 13
Methylene blue 13
AHF 13
Lovastatin 13
Eptifibatide 13
Bayer 12
ICI 12
ENT 11
Alanine 11
Asthma 11
CCL 11
Glutathione 11
NH3 11
lactose 10
Lovenox 9
TAK 9
Simvastatin 8
ZnO 8
Nafamostat mesilate 8
Gabexate mesilate 8
Sodium nitroprusside 8
Alteplase 8
Coumadin 8
AMC 8
CTX 8
balanced salt solution 8
Taxol 7
Surgicel 7
Fluorescein 7
TiO2 7
citric acid 7
Ringer's solution 7
ZnCl2 7
Dazoxiben 7
Amiloride 7
Pronase 7
Amiloride 7
Vitamin E 7
CPR 7
Fluorescein 7
Alteplase 7
ZnCl2 7
Glycyrrhiza 6
L-Asparaginase 6
Plavix 6
Trifluoperazine 6
G-CSF 6
Alteplase 6
ADM 6
Retinoic acid 6
Monensin 6
L-tyrosine 6
PDGF B-chain 6
Mutagen 6
SiO2 6
EE2 5
TAC 5
CDP 5
CTC 5
Desirudin 5
Glycerol 5
CTC 5
Ginseng 5
pyridoxal phosphate 5
Norplant 5
ampicillin 5
PTH 5
MRC 5
Nitric Oxide 5
Papain 5
Arsenic trioxide 5
Drotrecogin alfa 4
Norplant 4
TTC 4
Ouabain 4
Itraconazole 4
Cangrelor 4
G418 4
Kaolin 4
VCR 4
Chrysalin 4
Phentolamine 4
Dihydroergotamine 4
Hydroxyethylstarch 4
Drotrecogin alfa 4
AGG 4
more...
Enzyme
thrombin 33306
thromboplastin 4505
APC 2009
plasmin 1812
trypsin 1519
tissue plasminogen activator 1062
protein kinase C 901
urokinase-type plasminogen activator 590
phospholipase C 561
mitogen-activated protein kinase 494
kallikrein 491
chymotrypsin 478
elastase 396
phospholipase A2 381
protein kinase 372
glutathione S-transferase 230
neutrophil elastase 206
peroxidase 205
ERK 201
transglutaminase 179
adenylate cyclase 177
phosphodiesterase 150
lipoxygenase 148
cathepsin G 134
focal adhesion kinase 132
TAT 127
lactate dehydrogenase 116
apyrase 115
tryptase 112
ATPase 110
ACS 107
collagenase 106
thrombin-activatable fibrinolysis inhibitor 106
myosin light chain kinase 98
alkaline phosphatase 97
papain 96
superoxide dismutase 95
MEK 87
ancrod 87
guanylate cyclase 81
NO synthase 79
creatine kinase 79
tissue kallikrein 79
neuraminidase 78
catalase 77
phosphatidylinositol 3-kinase 73
heparinase 68
luciferase 68
calcineurin 66
caspase-3 66
alanine aminotransferase 61
reverse transcriptase 59
clotting enzyme 58
subtilisin 56
phosphoinositide 3-kinase 55
NADPH oxidase 54
deaminase 53
lysozyme 52
AMPK 49
ACE 47
Hageman factor 47
NADPH oxidase 47
hyaluronidase 46
pepsin 45
carboxypeptidase B 44
thermolysin 44
aequorin 43
phospholipase D 42
thromboxane synthase 38
beta-glucuronidase 38
renin 38
lipoprotein lipase 37
hexosaminidase 36
TGT 35
asparaginase 35
acetylcholinesterase 35
PKG 34
aspartate aminotransferase 34
MAP 33
cathepsin B 32
RNase 31
RNA polymerase 31
MMP 30
beta-galactosidase 29
12-lipoxygenase 27
RNase 27
chondroitinase 26
chondroitinase 26
acid phosphatase 25
NOS 25
DNase 25
matrix metalloproteinase 2 25
lipase 25
chymase 24
protein phosphatase 2A 24
cathepsin D 23
enterokinase 23
PNGase F 22
matriptase 22
CaMKII 22
PDE 22
CPN 22
matriptase 21
AMP-activated protein kinase 21
glucose oxidase 21
xanthine oxidase 20
hyaluronidase 20
cancer procoagulant 20
HIV-1 protease 19
CD10 19
ceruloplasmin 19
PTA 18
MMP-3 18
diacylglycerol kinase 18
transcriptase 17
proteinase K 17
carboxylesterase 17
glutathione peroxidase 17
dihydrofolate reductase 16
lysyl endopeptidase 16
proteasome 16
C3 convertase 15
P-glycoprotein 15
MEKK1 15
prostaglandin synthetase 15
cholinesterase 14
PI-PLC 14
ribonuclease 13
furin 13
coagulation factor VIIa 13
ribonuclease 13
C3 convertase 13
bromelain 13
5'-nucleotidase 13
gamma-glutamyl transpeptidase 13
methylenetetrahydrofolate reductase 12
methylenetetrahydrofolate reductase 12
IKK 12
matrix metalloproteinase 9 12
TSP-1 11
tyrosine hydroxylase 11
RVV-V 11
C1 esterase 11
cathepsin L 11
caspase-1 11
GRK5 11
factor D 10
coagulation factor XIa 10
neuropathy target esterase 10
ADPase 10
endoglycosidase H 10
p100 10
PARP 10
adenosine deaminase 10
CD13 10
heme oxygenase 10
CPR 10
adenosine deaminase 10
15-lipoxygenase 10
DCF 9
more...
Compound
calcium 3656
Thrombin 3477
ADP 2729
Dec 2408
ADP 2172
ADP 2153
arginine 1858
Clin 1797
DNA 1396
serine 1351
sodium 1223
sulfate 1148
tyrosine 835
prostacyclin 709
Heparin 680
ATP 678
SDS 656
Phe 656
acetate 648
lysine 617
phosphate 582
Gly 561
Fibrinogen 491
cAMP 477
Fibrin 473
nitric oxide 455
alanine 448
EDTA 423
water 419
Asp 419
oxygen 409
EDTA 393
His 368
Cardiol 361
NH2 350
leucine 342
AMP 323
cysteine 306
threonine 300
glucose 281
hydrogen 281
cGMP 277
prostaglandin E1 252
salt 211
methionine 205
GTP 203
ASA 201
urea 174
PEG 172
Ile 164
TNF 160
ethanol 159
galactose 154
DEAE 152
CaCl2 149
Triton X-100 145
PMA 145
TEM 138
PAR 132
Warfarin 129
PMA 128
Collagen 126
ACS 125
iron 122
Factor X 121
creatinine 120
PEG 118
Plasmin 118
FDP 117
proline 114
potassium 113
5-HT 112
bromide 111
H2O2 111
DIC 109
zinc 108
ACS 107
glycerol 106
Mg2+ 104
Argatroban 104
TXA2 104
ammonium 103
tryptophan 102
Trypsin 100
nitrogen 95
manganese 95
PGE2 95
COS 87
tryptophan 85
tryptophan 84
tryptophan 84
PMSF 83
silver 74
Adrenal 74
TOF 73
barium 72
copper 72
Vitamin K 70
HCl 69
glutamate 69
Tris 69
Fibrinopeptide A 68
noradrenaline 65
MDA 64
Indomethacin 62
nickel 62
Arachidonic acid 62
Serine 61
glutamine 61
guanidine 60
Tris 57
iodine 57
homocysteine 57
GMP 56
Triton 56
TPA 56
TPA 55
CO2 55
MEK 53
aspartic acid 52
aspartic acid 51
aspartic acid 51
GSH 51
aspartic acid 51
GSH 51
Thromboxane 50
acrylamide 49
PGE 49
Dermatan sulfate 49
acetic acid 48
Optimal 48
glutamic acid 48
GDP 47
Tyrosine 46
APAP 44
ETH 44
THP 44
THP 43
aldehyde 43
Bradykinin 43
hydroxylamine 42
hydroxylamine 42
retinoic acid 41
asparagine 41
Adenosine 41
DMSO 40
formaldehyde 40
prostaglandin F1 40
MAP 39
PLA 39
formaldehyde 39
nitrate 38
vinyl 38
Histamine 38
pyridine 37
hyaluronic acid 37
MTT 36
PGH2 36
aldehyde 35
phosphorus 35
more...