Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.5 (thrombin)
 33,306 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors present an extremely rare case of a pseudoaneurysm of the ulnar artery as a complication of a two-portal endoscopic carpal tunnel release (ECTR). A 70-year-old man with chronic renal failure and on maintenance hemodialysis with a left arteriovenous fistula presented with paresthesia of his right hand. A clinical diagnosis of right carpal tunnel syndrome was confirmed by ultrasonography and an electrophysiologic study. He underwent two-portal ECTR, and the paresthesia was much improved. However, he presented to us one month after operation with severe pain, a tender mass distal to the right wrist crease and more aggravation of the paresthesia in the ulnar nerve distribution. Doppler ultrasound was performed and revealed a hypoechoic lesion 20 mm in diameter in the right palm, with arterial Doppler flow inside connected to the palmar segment of the ulnar artery. An ulnar artery pseudoaneurysm was diagnosed and treated by ultrasound-guided percutaneous thrombin injection. Transverse color Doppler ultrasound image showed complete thrombosis of the pseudoaneurysm and flow cessation after a total injection of 500 units of thrombin. The symptoms were also improved.
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PMID:Pseudoaneurysm of ulnar artery after endoscopic carpal tunnel release. 2111 71

A 47-year-old woman presented with paresthesia in her left arm and trunk. She was diagnosed as having an arterial pure sensory stroke at first presentation. On the second hospital day, left hemiparesis developed after convulsions. Magnetic resonance (MR) imaging revealed a hyperintense lesion involving the right parietal lobe on diffusion weighted image. The T2* weighted image disclosed a linear hypointense lesion in the same area. Progressive feature of her symptoms and T2* weighted MR image prompted us to perform MR venography. MR venography confirmed the diagnosis of cortical vein and sagittal sinus thrombosis. Her symptoms attenuated gradually after anticoagulation therapy. Gene analysis showed type I anti-thrombin III (ATIII) deficiency due to the novel mutation of AT III gene. T2* weighted imaging may be much more sensitive than other imaging to detect thrombosed cortical vein during the first week after onset. Rapid diagnosis induced appropriate treatment and monitoring of the patient.
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PMID:Diagnosis of cerebral cortical vein thrombosis with T2* weighted magnetic resonance imaging. 2189 45