Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.5 (thrombin)
 33,306 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mesenteric venous thrombosis is a rather rare condition posing diagnostic problems and very often with an obscure etiology. Recently, various coagulation deficiencies were found as the main etiologic factor. A case of a 75-year-old man with acute abdomen is presented. Exploratory laparotomy revealed a 250 cm necrosis of the small intestine. Patient was successfully treated by resecting the entire involved segment of the bowel. After a complete coagulation profile examination, deficiencies of protein C and anti-thrombin III were found and were considered as the main cause of the disease. In cases with known coagulation deficiencies the presence of an acute abdomen should raise suspicion of mesenteric venous thrombosis.
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PMID:Mesenteric venous thrombosis due to coagulation deficiencies - a case report. 891 41

The authors review the case of a fifty-three-year-old cirrhotic patient. He was admitted to the emergency unit with symptoms of acute abdomen and haemorrhagic shock. Abdominal bleeding of unknown origin was revealed by UH and CT imaging. After circulatory resuscitation, urgent abdominal exploration was indicated. During operation arterial bleeding of a ruptured cirrhotic nodulus was found. Tacho-Comb (a human fibrinogen/thrombin coated collagen patch) was applied onto the hepatic wound. Prompt haemostasis was achieved. The patient was discharged after an uneventful postoperative period.
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PMID:[Ruptured cirrhotic nodulus treated with collagen patch]. 1805 63