Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.5 (thrombin)
 33,306 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The changes of pH gradient on serotonin organelle membranes can be observed using the fluorescent marker acridine orange. This gradient decreases with thrombin activation of the blood plates. The fall of delta pH can be induced by ammonium salts which also influence the ADP-induced cellular aggregation. NH4 ions added simultaneously with low doses of ADP potentiate cellular aggregation, and added after ADP-induced interaction of cells lead to another wave of intercellular contacts inhibited by mepacrin. Fluorescent acridin aminoderivatives can be used both for kinetic observations of delta pH on the serotonin organelle membranes of native platelets and for studying the interaction of the systems responsible for maintaining this gradient with the systems of prostaglandin and adenine nucleotide metabolism.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1985
PMID:[pH changes in the matrix of serotonin organelles of stimulated thrombocytes]. 400 58

A new antiarrhythmic drug of phenothiazine series diethylamine ethmozine analogue inhibited the rabbit's platelet aggregation induced by ADP, serotonin and thrombin. The degree of inhibition depended on the drug concentration and time of its incubation with platelets as well as on the inducer concentration. The transition from ADP-induced (5 microM) aggregation to reversible one was observed under the influence of relatively small doses of the drug. A gradual restoration of the platelet aggregating capacity occurred after washing platelets off the drug. The nonadditive character of the studied agent effects and that of theophylline on the platelets makes it possible to suppose that cAMP participates in the mechanism of the drug action on the platelets. The described antiaggregating effect of the drug on the platelets should be taken into account when it is used as an antiarrhythmic agent.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1983
PMID:[Antiaggregating action on thrombocytes of a new anti-arrhythmia agent of the phenothiazine series--diethylamine ethmozine analog]. 631 30