Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
chymotrypsin 4896
Sep 2983
Mol 2164
SDS 2011
polypeptide 1814
trypsin inhibitor 1781
Trypsin 1776
thrombin 1535
mast cell 1226
amylase 1207
glycoprotein 1179
ATP 1145
collagenase 1118
serine protease 1100
collagen 1017
lipase 1003
insulin 887
neuraminidase 858
serum albumin 733
ATPase 681
casein 637
chymotrypsin-like 619
protease inhibitor 605
TOF 597
kallikrein 590
albumin 589
lectin 561
chymase 550
trypsinogen 506
gut 480
lysozyme 473
membrane-bound 453
fibronectin 441
IgE 440
proteasome 409
Gen 385
membrane protein 375
cholecystokinin 375
microsomal 373
ADP 369
endoplasmic reticulum 368
alkaline phosphatase 364
Met 359
bradykinin 350
ESI 346
peptidase 344
fibrinogen 331
cytokine 329
urokinase-type plasminogen activator 323
esterase 322
NMR 306
AMP 299
renin 297
hemoglobin 294
factor Xa 285
proteoglycan 280
calmodulin 279
GTP 278
hyaluronidase 274
plasminogen 270
alpha-amylase 268
secretin 261
peroxidase 260
Pseudomonas 260
serine protease inhibitor 260
lipopolysaccharide 251
histone 250
cytochrome c 249
threonine 248
PLA 246
cathepsin G 244
glucosamine 241
mast cell tryptase 240
heavy chain 239
Chymotrypsin 232
fused 232
neutrophil elastase 230
dimeric 220
myosin 220
epidermal growth factor 219
alpha 1-antitrypsin 215
RNase 213
thymus 210
phospholipase A2 204
carboxypeptidase B 203
DNase 202
PAR-2 201
catalase 199
phosphatase 197
cathepsin B 194
spermatozoa 193
ubiquitin 189
transferrin 188
interferon 188
mucin 186
aminopeptidase 185
urinary kallikrein 181
Proteinase 181
tumor necrosis factor 169
IL-6 168
myoglobin 160
superoxide dismutase 160
adenylate cyclase 152
lymphoid 151
HNE 148
C18 146
NADPH 143
TNF 142
cathepsin D 142
cytochrome 141
glucagon 139
reductase 138
brush border 138
NADH 137
ACR 135
Ang II 133
type I collagen 132
pancreatic secretory trypsin inhibitor 131
CCK 129
enterokinase 129
IL-8 129
IgA 128
phosphodiesterase 126
serine proteinase inhibitor 125
ABC 125
c-kit 123
acetylcholinesterase 123
chondroitinase 121
substance P 119
prothrombin 117
eosinophil cationic protein 116
dilute 116
elastin 115
Pol 115
leucine aminopeptidase 114
insulin receptor 110
phospholipase 109
SOD 109
GSH 108
NAD 108
acid phosphatase 108
C-terminal peptide 108
deoxyribonuclease 108
pancreatic lipase 107
GDP 106
lactate dehydrogenase 106
cAMP-dependent protein kinase 105
IL-4 105
stem cell factor 104
cysteine protease 104
apoE 104
antithrombin III 102
tRNA 102
growth hormone 102
beta-endorphin 102
PEG 100
beta 1 99
angiotensin II 98
PAR2 98
nerve growth factor 97
more...
Disease
SDS 2018
cancer 1195
tumor 1177
pancreatitis 559
acute pancreatitis 493
influenza 335
carcinoma 326
asthma 319
plaque 287
diabetes 280
cold 254
cystic fibrosis 249
chronic pancreatitis 244
leukemia 217
anaphylaxis 205
hepatocellular carcinoma 203
breast cancer 193
mastocytosis 191
adenocarcinoma 191
melanoma 177
Alzheimer's disease 173
HIV 160
uterus 150
Pancreas 150
multiple myeloma 150
Pancreas 144
cholera 144
hypertension 139
mole 131
virus infection 131
mole 125
rheumatoid arthritis 117
SEM 114
pancreatic cancer 114
pancreatic insufficiency 114
lymphoma 110
MCF 108
GSH 108
metastases 104
neuroblastoma 99
pertussis 93
infectious diseases 93
malaria 93
atherosclerosis 93
Mycoplasma 92
arthritis 87
celiac disease 85
allergic rhinitis 85
immunodeficiency 84
mastocytoma 83
carcinogenesis 81
prostate cancer 77
emphysema 77
periodontitis 77
Mycobacterium 75
tumor growth 75
atopic dermatitis 75
ischemia 75
sarcoma 75
tumor progression 74
squamous cell carcinoma 71
pruritus 69
osteoarthritis 68
herpes simplex 66
steatorrhea 65
depression 65
vaccinia 65
glioma 62
pneumonia 62
systemic lupus erythematosus 60
Adhesion 60
avian influenza 59
stomatitis 58
Klebsiella 58
worms 57
cirrhosis 57
hepatitis 56
sepsis 56
gastroenteritis 55
dengue 53
psoriasis 53
lung cancer 52
hepatitis B 52
Dissociation 51
malabsorption 51
colon cancer 51
fibrosarcoma 51
urticaria 50
sepsis 50
Infection 49
fits 48
pheochromocytoma 47
PHA 47
diabetic retinopathy 46
diphtheria 46
glomerulonephritis 46
acute myeloid leukemia 45
TEM 45
inflammatory bowel disease 45
ovarian cancer 45
Rous sarcoma 45
chronic obstructive pulmonary disease 45
Bordetella 44
Haemophilus 44
type 2 diabetes 44
gastric cancer 43
tumorigenesis 43
cornea 43
mouth disease 43
Schistosoma mansoni 43
chronic renal failure 42
Newcastle disease 42
myocardial infarction 41
periodontal disease 40
obesity 40
AIDS 40
ash 40
tuberculosis 40
stroke 38
irritable bowel syndrome 38
renal disease 38
epididymis 38
cytomegalovirus 37
West 37
dehydration 36
Chlamydia 36
proteinuria 36
liver disease 36
amyloidosis 35
eosinophilia 35
cataract 34
infestation 34
hyperglycemia 34
Parkinson's disease 34
lung carcinoma 33
anemia 33
rhinitis 33
colorectal cancer 33
colitis 33
SARS 33
bacterial infection 32
retinopathy 32
acute lymphoblastic leukemia 32
Evans 32
measles 32
rash 32
multiple sclerosis 32
renal failure 31
enteritis 31
TEM 31
dermatitis 31
Yersinia 31
chronic myeloid leukemia 30
glioblastoma 30
Plaque 30
mastitis 29
disseminated intravascular coagulation 29
EDC 29
Blocking 29
hepatitis C 29
more...
Symptom
diarrhea 175
pain 130
anesthesia 80
starvation 60
collapse 58
autodigestion 56
abdominal pain 47
vomiting 39
agitation 38
flushing 36
tremor 26
HSA 26
acidity 24
seizures 19
erythema 19
Spots 19
respiratory distress 17
sneezing 15
nausea 15
headache 14
exhaustion 13
Welt 12
cough 12
fatigue 11
weakness 11
dyspnea 11
stigma 9
hypoproteinemia 9
discomfort 9
syncope 9
wheezing 9
analgesia 9
discomfort 9
regurgitation 8
angina 8
Ill 7
rundown 7
dry skin 7
thinning 7
lethargy 7
anorexia 7
cachexia 7
functional recovery 7
rhinorrhea 7
hepatosplenomegaly 6
hypothermia 6
spasm 6
hyperoxia 6
splenomegaly 6
overweight 5
colic 5
eds 5
arthralgia 5
chest pain 5
epigastric pain 5
bloating 4
stridor 4
constipation 4
skin damage 4
cancer pain 4
bone pain 4
back pain 4
Wind 4
halitosis 4
hepatomegaly 3
chills 3
heartburn 3
paresis 3
Darier's sign 3
hemoptysis 3
nasal discharge 3
nausea and vomiting 3
Nasal symptoms 3
polyuria 3
twitching 3
sleepiness 3
bitter taste 3
shortness of breath 3
dry eye 3
nasal congestion 3
low back pain 3
masculinization 3
hunger 2
hypercapnia 2
microbial colonization 2
skin irritation 2
prostration 2
scaly skin 2
pelvic pain 2
Decreased activity 2
cyanosis 2
dizziness 2
anosmia 2
DNA marker 2
acute abdominal pain 2
ataxia 2
Mills 2
urinary frequency 2
Hudson 2
No toxic effect 2
orofacial pain 1
incoordination 1
generalized rash 1
acute pain 1
PUO 1
oliguria 1
acute abdomen 1
hoarseness 1
leg edema 1
Flare 1
polydipsia 1
paraparesis 1
pallor 1
rigors 1
decreased appetite 1
ACHE 1
apathy 1
presyncope 1
bladder pain 1
adenitis 1
CSR 1
acid regurgitation 1
general problem 1
photophobia 1
chorea 1
stomach pain 1
Gastrointestinal symptoms 1
No adverse effect 1
tense 1
Blanching 1
Local swelling 1
chronic cough 1
Anoxia 1
tinnitus 1
acute stress 1
Neuropathic pain 1
knee pain 1
emaciation 1
catatonia 1
Fluctuation 1
enuresis 1
postnasal drip 1
asthenia 1
right upper quadrant pain 1
neuralgia 1
Mucoid sputum 1
blurred vision 1
fever of unknown origin 1
memory loss 1
flank pain 1
disturbed balance 1
Halo 1
hypotonia 1
prominent nose 1
generalized erythema 1
distraction 1
vertigo 1
dyslalia 1
Bladder distention 1
Drug
lysine 1409
Gel 442
Asn 357
Dermatol 327
Pronase 256
NADH 137
ABC 125
Aprotinin 116
CaCl2 112
CaCl2 112
CaCl2 112
lactose 86
ascorbate 81
DNase I 76
CSF 73
IL-2 69
Histamine 67
IFN-gamma 66
DFP 65
Leaf 65
Albumin 62
Papain 59
FAD 57
Asthma 54
L-tyrosine 54
Fragment 52
Fraction 48
NAG 45
MAP 44
pyridoxal phosphate 41
AMC 39
uPA 35
ROS 34
balanced salt solution 34
Biopolymers 32
Gelatin 32
Secretin 29
caffeine 26
Alanine 25
PTH 25
Acacia 23
ampicillin 23
Cardiovasc 22
Nephron 22
Indomethacin 21
CAM 21
MRC 20
citric acid 20
Ethanol 20
Glucagon 20
Capsicum 18
Ringer's solution 18
Cibacron Blue 17
vitamin E 17
CTX 17
Fluorescein 17
Glutathione 16
Paraffin 16
Bifidobacterium 15
Bromelain 15
PTC 15
Mutagen 15
Allergen 15
Atropine 14
Fluorescein 14
Hypaque 14
TAT 14
Hypaque 13
Monit 13
Angiotensin II 13
TiO2 12
CCL 12
Hyaluronidase 11
Hyaluronidase 11
NH3 11
MgSO4 10
ZnCl2 10
PCP 10
CDP 10
EE2 10
ZnCl2 10
Spectrum 10
Bortezomib 10
Urokinase 10
Captopril 10
Nephron 10
Gabexate mesilate 10
Vitamin B 9
Antithrombin III 9
FeCl3 9
Thyroglobulin 9
Monensin 9
Pancreatin 9
Dial 9
p75 9
ICI 8
NBT 8
Amiloride 8
Amiloride 8
nitroglycerin 8
ISP 8
DHT 8
GRF 8
G-CSF 8
Vitamin B12 8
Nitric Oxide 8
DHT 8
Cimetidine 7
Bayer 7
Retinoic acid 7
Heme 7
Itraconazole 7
Lactase 7
Streptokinase 7
CPR 7
THF 7
Cimetidine 7
Serum albumin 7
Phosphatidylserine 7
Glycerol 7
Pepstatin 6
HCH 6
BoNT/A 6
CoCl2 6
Silica 6
Spectrum 6
CoCl2 6
niacin 6
PE2 6
Pyridoxal 6
Forskolin 6
Galactose 6
ZnO 6
Lovastatin 5
Luteinizing 5
-deoxyadenosine 5
Vitamin A 5
NaI 5
Triclosan 5
Trifluoperazine 5
Imatinib 5
NaI 5
Fructose 5
Fennel 5
EPI 5
beta-Galactosidase 5
CTT 5
APD 5
Tannic acid 5
HCG 5
Cobalamin 5
NaI 5
K-252a 5
Kenyan 5
Ulinastatin 5
Loxiglumide 5
NaI 5
CTA 5
Taxol 4
TAC 4
more...
Enzyme
trypsin 42187
chymotrypsin 5478
tryptase 2412
thrombin 1519
pepsin 1491
elastase 1418
collagenase 1166
plasmin 1106
papain 1088
lipase 1016
neuraminidase 908
kallikrein 794
ATPase 734
subtilisin 720
proteinase K 547
chymase 529
proteasome 503
lysozyme 477
RNase 473
thermolysin 463
peroxidase 460
protein kinase 446
RNase 424
neutrophil elastase 374
DNase 370
thromboplastin 366
alkaline phosphatase 364
hyaluronidase 362
urokinase-type plasminogen activator 337
renin 297
phospholipase A2 296
alpha-amylase 281
phospholipase C 277
hyaluronidase 274
cathepsin G 272
protein kinase C 226
tissue kallikrein 226
ribonuclease 220
ribonuclease 219
catalase 214
CD10 209
carboxypeptidase B 206
carboxypeptidase A 197
cathepsin B 194
ERK 186
superoxide dismutase 185
tissue plasminogen activator 184
enterokinase 175
mitogen-activated protein kinase 163
bromelain 157
adenylate cyclase 156
acetylcholinesterase 137
ACE 136
cathepsin D 136
acrosin 136
phosphodiesterase 132
beta-galactosidase 131
glutathione S-transferase 130
endoproteinase Glu-C 124
chondroitinase 122
lactate dehydrogenase 122
chondroitinase 121
APC 118
deaminase 115
alpha-glucosidase 114
acid phosphatase 113
leucine aminopeptidase 113
AMPK 111
deoxyribonuclease 104
deoxyribonuclease 104
ficin 100
PNGase F 99
lysyl endopeptidase 96
reverse transcriptase 95
transglutaminase 94
RNA polymerase 93
calcineurin 92
ATP synthase 92
carboxypeptidase Y 88
invertase 85
furin 84
phosphorylase 83
clostripain 80
CD13 80
MMP-3 78
ACS 78
tyrosinase 74
endoglycosidase H 71
beta-glucuronidase 70
carboxylesterase 69
cathepsin L 67
CPR 65
aspartate aminotransferase 63
lipoxygenase 63
creatine kinase 62
cholinesterase 59
sucrase 58
matriptase 57
caspase-3 56
chitinase 55
isoamylase 55
micrococcal nuclease 54
heparinase 53
matriptase 53
glutathione peroxidase 51
sialidase 51
gamma-glutamyl transpeptidase 50
Hageman factor 48
endoproteinase Asp-N 48
alpha-mannosidase 48
pyruvate kinase 47
dipeptidyl peptidase IV 47
matrix metalloproteinase 2 47
lactase 46
ceruloplasmin 46
cellulase 46
glyceraldehyde-3-phosphate dehydrogenase 46
phospholipase D 45
beta-lactamase 45
luciferase 45
glyceraldehyde-3-phosphate dehydrogenase 45
diaphorase 45
focal adhesion kinase 44
pyruvate dehydrogenase 44
prolyl endopeptidase 43
glutamate dehydrogenase 43
glutamate dehydrogenase 43
glutamate dehydrogenase 43
prostate-specific antigen 42
ricin 42
beta-glucosidase 42
hexosaminidase 41
glyceraldehyde-3-phosphate dehydrogenase 41
DNA polymerase 41
PDE 40
carbonic anhydrase 40
phytase 39
alcohol dehydrogenase 39
dihydrofolate reductase 39
endonuclease 39
xanthine oxidase 38
phytase 38
phosphorylase kinase 38
P-glycoprotein 38
matrix metalloproteinase 9 38
alanine aminotransferase 38
enolase 37
PARP 37
glutathione reductase 37
glucose oxidase 36
galactose oxidase 36
glyceraldehyde-3-phosphate dehydrogenase 36
glyceraldehyde-3-phosphate dehydrogenase 36
beta-glucosidase 35
MMP 35
chitin synthase 34
cGMP phosphodiesterase 34
myosin light chain kinase 34
interstitial collagenase 34
SPC 34
more...
Compound
serine 3049
Dec 2973
sodium 2822
arginine 2808
lysine 2534
sulfate 2154
SDS 2149
calcium 2028
DNA 2012
Trypsin 1776
water 1368
Clin 1363
cysteine 1222
ATP 1146
alanine 1071
leucine 1032
Phe 980
phosphate 956
tyrosine 934
methionine 919
EDTA 913
EDTA 913
His 882
Gly 846
Asp 840
ammonium 787
glucose 781
salt 766
NH2 764
urea 749
DEAE 720
bromide 719
galactose 680
threonine 670
TOF 597
hydrogen 556
Ile 539
acetate 528
oxygen 494
Triton X-100 494
Mg2+ 428
tryptophan 397
zinc 387
tryptophan 385
ADP 383
tryptophan 375
tryptophan 375
ADP 369
ADP 369
ethanol 356
HCl 338
proline 330
AMP 325
GTP 314
iron 313
cAMP 311
nitrogen 306
PEG 295
guanidine 272
methanol 265
acrylamide 251
potassium 240
copper 230
acetic acid 226
acetone 216
glutamic acid 207
PEG 198
Tris 195
TCA 194
asparagine 194
aspartic acid 194
GlcNAc 192
manganese 191
aspartic acid 191
silver 190
aspartic acid 189
aspartic acid 188
Serine 181
glutamine 177
glycerol 174
Thrombin 171
chloroform 169
valine 167
Tris 164
formaldehyde 154
NAD 149
nitric oxide 147
NADPH 143
NADPH 143
TNF 142
2-mercaptoethanol 141
NADH 137
iodine 137
isoleucine 136
aldehyde 134
isoleucine 133
PMSF 131
hyaluronic acid 131
hydroxylamine 128
aldehyde 126
TPCK 123
hydroxylamine 123
glutamate 122
Insulin 122
GSH 121
GSH 121
acetonitrile 116
formaldehyde 114
hexose 114
CaCl2 112
GalNAc 112
NAD 108
CO2 107
GDP 107
Heparin 104
cGMP 102
H2O2 102
Optimal 101
COS 94
cobalt 93
phenol 92
Triton 91
carbonate 89
NADP 89
ACS 89
nickel 86
Collagenase 84
CoA 83
MgCl2 82
ammonia 79
octyl 77
ACS 77
PAR 77
octyl 77
octyl 77
sodium chloride 74
Sodium 67
MTT 67
Histamine 67
MCA 66
MCA 65
phosphoserine 64
phosphorus 63
creatinine 63
hydroxide 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
formic acid 62
PAM 61
PAM 61
Kallikrein 61
ACTH 60
cadmium 60
more...