Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To investigate the effects of age and posture on plasma active and inactive renin, we measured the plasma active renin concentration (ARC) and inactive renin concentration (IRC) in 81 healthy subjects. The subjects were divided into five groups according to age and body position at the time the blood was taken. Group I included 15 five-day-old newborns in a supine position. Group H included 18 adults, aged from 20 to 50 years, who were in a supine position. Group III included 21 adults, over 50 years old, who were in a supine position. Group IV included 20 adults, aged from 20 to 50 years, who were in an upright position. Group V included 19 adults, over 50 years old, who were in an upright position. Twelve subjects were included in Groups II and IV. Plasma active renin was measured by the amount of angiotensin I general when an exogenous renin substrate was added. Plasma inactive renin was activated by trypsin. The results showed that, in a supine position, both ARC and IRC were significantly higher in newborns (Group I) than in the two adult groups (Groups II and III). The mean of the ARC/TPRC (total plasma renin concentration) ratio was lower in adults over 50 years old (Group III) than in those from 20 to 50 years old (Group II), but the difference was not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effects of age and posture on plasma active renin and plasma inactive renin in normal subjects. 135 17

The fate of circulating inactive prorenin was examined in patients and volunteers. Prorenin was activated either by acid-dialysis with warming at pH 3.3 or with trypsin. The results were similar but omission of warming reduced the value by 13%. In 6 volunteers, 20 min forearm venous occlusion raised regional total (T) and inactive (I) plasma renin concentration (PRC) by 51% and 48% without change of active (A) renin. During intense forearm exercise the ratio APRC: IPRC did not change in muscle or skin venous blood. Body anaerobic exercise increased APRC 3.7-fold without change in IPRC. These procedures activate plasminogen but are without effect on prorenin. In 18 patient with stable angina, TPRC was lower in coronary sinus than arterial blood (p less than 0.001) but APRC was not affected. A-V differences were not detected across the leg. Prorenin is apparently stable in the circulation but extracted by the heart.
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PMID:Potential functions of plasma prorenin; regional activation and tissue extraction. 330 99