Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ligatin is a filamentous plasma membrane protein that serves as a baseplate for the attachment of peripheral glycoproteins to the external cell surface. Ligatin can be released from intact, embryonic chick neural retinal cells by treatment with 20 mM Ca++ without adversely affecting their viability, alpha-Glucose-1-phosphate is also effective in removing ligatin-associated glycoproteins from intact cells. After eight of these treatments, the retinal cells seem not to exhibit Ca++-dependent adhesion for one another. It is thus suggested that ligatin in neural retina may serve as a baseplate for the attachment to the cell surface of glycoproteins active in Ca++-dependent adhesion. The finding that Ca++ serves to protect Ca++-dependent adhesion molecules from digestion by trypsin is discussed in relation to steric constraints on trypsin's accessibility to these adhesion molecules because of their possible binding to arrayed ligatin filaments.
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PMID:A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion. 708 79