Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.4 (
trypsin
)
42,187
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sea urchin egg
NAD+ kinase
(
ATP:NAD+ 2'-phosphotransferase
,
EC 2.7.1.23
), a calmodulin-dependent enzyme, can be activated by a moderate treatment with
trypsin
in a similar fashion to calmodulin. Stimulation by
trypsin
is dependent on its concentration (half-maximal dose: 1.5 microgram/ml) but independent of the presence of calcium. This suggests that limited proteolysis is able to activate
NAD+ kinase
as described for several other calmodulin-activated enzymes and that these enzymes may interact with calmodulin in a similar way.
...
PMID:Activation of calmodulin-dependent NAD+ kinase by trypsin. 627 62
