Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.4 (
trypsin
)
42,187
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Role of peptide bond breaks in the incorporation of amino acids into proteins in a "protein--amino acid" system is investigated. For this purpose the incorporation of labelled amino acids into
trypsin
under the inhibition of its autolysis by a specific inhibitor from soybean and epsilon-amino-caproic acid is studied. The trypsin inhibitor from soybean is found to suppress considerably the incorporation of 14C-glycine, 14C-lysine and 14C-methionine into crystal
trypsin
and not to affect the incorporation of labelled amino acids into chomotrypsin, papain and carboxypeptidase.
Epsilon-Aminocaproic acid
inhibited 14C-glycine incorporation into crystal
trypsin
by 40% and did not change its incorporation level into serum albumin. The dependency of amino acid incorporation level into
trypsin
on the activity of autolysis in the "protein--amino acid" system is demonstrated.
...
PMID:[Effect of proteolysis inhibitors on the incorporation of labelled amino acids into proteins]. 121 56
