Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten 2-[acyl-N-(substituted benzylidene)hydrazino]5-phenyltetrazoles were synthesized, characterized and evaluated for anti-inflammatory and antiproteolytic activity. The protection afforded by these tetrazoles at a dose of 100 mg/kg i.p., against carrageenin-induced edema in rats, ranged from 11 to 46%. Oxyphenbutazone (40 mg/kg i.p.), and hydrocortisone (10 mg/kg i.p.), used as reference drugs, exhibited protection of 54 and 47%, respectively. The antiproteolytic activity of these tetrazoles, as reflected by their ability to inhibit trypsin-induced hydrolysis of bovine serum albumin, ranged from 17 to 57%. The antiproteolytic activity was found to be unrelated to the anti-inflammatory activity possessed by these tetrazoles.
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PMID:Anti-inflammatory and antiproteolytic properties of 2-[acyl-N-(substituted benzylidene)hydrazino]5-phenyltetrazoles. 68 74

Eight 1-(5-aryl-2-acetyltetrazolyl)-3-substituted carbamides were evaluated for their antiinflammatory and antiproteolytic properties. The protection afforded by these compounds (100 mg/Kg, i.p.) against carrageenin-induced edema in rats ranged from 10-45%. Oxyphenbutazone (40 mg/kg, i.p.) and hydrocortisone (10 mg/kg, i.p.), used as reference drugs, possessed 53% and 45% antiinflammatory activity, respectively. All substituted tetrazolyl carbamides (1 mM) possessed antiproteolytic activity which was reflected by their ability to inhibit the activity of trypsin during hydrolysis of bovine serum albumin. The degree of protection observed against trypsin-induced hydrolysis ranged from 25-62% while such an inhibition with sodium salicylate (1 mM) was 52%.
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PMID:Antiinflammatory and antiproteolytic properties of substituted tetrazolycarbamides. 707 83