Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The possibility of in vitro lysis of fibrinous clots was shown experimentally (a model of blood flow in a vessel incompletely occluded by a thrombus) using the magnet-directed transport of trypsin immobilized on a magnet-susceptible carrier. During the clot lysis no fibrinolytics were recorded in the solution washing the clots, and lysis took place under the influence of trypsin on the magnetic carrier which precipitated on the surface of the clot and remained there for the necessary time (about 2 hours). The method of thrombus lysis suggested allows the dose of the injected drug to be decreased and does not require therapeutic concentration of thrombolytics in the general blood flow.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1985
PMID:[Substantiation of using magnet-directed localization of drugs for the treatment of thrombosis]. 400 51

The data are presented on fractionation of cardiac and skeletal muscle Ca2+-ATPase fragments obtained by trypsin and cyanobromide hydrolysis. Amino acid composition of Ca2+-ATPases isolated from the heart and skeletal muscles and of enzyme fragments is determined. The ionophoric properties of the intact enzyme and its fragments are studied. The low-molecular weight enzyme fragment decreases velocity and the level of Ca2+-accumulation by the vesicles of sarcoplasmic reticulum. It is suggested that an "ionphoric" fragment of muscle ATPase is able to form transmembrane Ca2+-selective channel in model lipid membranes.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1981
PMID:[Ca2+-dependent ATPases of the sarcoplasmic reticulum of skeletal and cardiac muscles and their ion-transporting fragments]. 645 8