Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Earlier histological studies have demonstrated that copper deficiency results in a selective and progressive atrophy of pancreatic acinar tissue. The present study examined both biochemical and morphological changes of the exocrine pancreas in nutritional copper deficiency. Groups of mature female rats were fed a purified diet either deficient (less than 0.5 micrograms/g) or sufficient (6.2 micrograms/g) in copper for 6 wk. Copper deficiency resulted in distinct ultrastructural changes in acinar cells, including marked variability in zymogen granule content, autophagic vacuoles and dilation of acinar lumen. Pancreatic weight and total DNA, RNA and protein content of the pancreas were similar in both groups of rats, whereas pancreatic amylase, trypsin and chymotrypsin activity was significantly lower in the copper-deficient group. In addition, secretagogue-induced release of these enzymes from dispersed acini isolated from copper-deficient rats was significantly reduced in comparison to enzyme secretion from normal controls. Pancreatic Cu-Zn and Mn superoxide dismutase activity was also found to be significantly lower in the copper-deficient rats than in normal controls. We conclude that nutritional copper deficiency in adult female rats reduces the responsiveness of the pancreas to secretagogues and may increase the susceptibility of the pancreas to oxidative damage.
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PMID:Morphological and biochemical changes in the pancreas of the copper-deficient female rat. 247 34

This study was designed to examine changes in exocrine pancreatic function in male rats consuming a diet containing either 62% starch or fructose with either 6.0 ppm or copper for 39 days. Copper deficiency significantly lowered pancreatic weight, copper concentration, and amylase and lipase specific activities in the pancreas and in washings from the small intestine. Significantly lower values were observed in copper deficient rats consuming fructose when compared to those consuming starch. In addition, chymotrypsin and trypsin specific activities in the pancreas and trypsin specific activity in the small intestine were lower in copper deficient rats consuming fructose when compared to all other dietary groups. Low dietary copper in combination with the consumption of high dietary fructose lead to an interaction which severely affected exocrine pancreatic function in ways which cannot be explained either by copper deficiency or dietary fructose consumption alone.
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PMID:Exocrine pancreatic function of rats consuming a high-fructose, low-copper diet. 262 88