Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.4 (trypsin)
 42,187 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to investigate simultaneously the endogenously stimulated exocrine pancreatic secretion and the cholecystokinin (CCK) response in patients suffering from coeliac sprue. A Lundh-test was performed in nine patients and twenty-six healthy volunteers. Basal plasma-CCK levels (3.4 +/- 0.5 pmol/l in sprue patients vs. 4.1 +/- 0.5 pmol/l in controls) and the integrated 120 min postprandial CCK values showed no differences in both groups. However, in controls the peak CCK value of 27.5 +/- 5.6 pmol/l appeared after 15 minutes whereas in sprue patients the peak of 18.9 +/- 4.5 pmol/l appeared after 60 minutes. CCK concentrations in duodenal biopsies of patients with coeliac sprue revealed significantly lower values compared to controls (123.4 +/- 37.4 versus 240.0 +/- 11.3 pmol/g wet weight). The stimulated lipase output was significantly lower throughout the whole sampling period in coeliac sprue patients whereas amylase output showed an inconstant reduction. The trypsin output was not altered. These results suggest that other mediators than CCK are responsible for the maintenance of trypsin output and for the reduction of lipase output in patients with coeliac sprue.
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PMID:Plasma cholecystokinin and pancreatic enzyme secretion in patients with coeliac sprue. 243 88

Pancreatic function was determined (using the secretin-pancreozymin test) before the use of gluten-free diet in 22 patients with endemic (celiac) sprue. Water and bicarbonate secretion were within normal limits, if anything there was a trend to high-normal values. Remarkable and apparently characteristic for celiac sprue was the only slight contraction of the gallbladder after intravenous injection of submaximal doses of cholecystokinin-pancreozymin (CCK). Secretion of the 3 enzymes amylase, lipase and trypsin was decreased in about one third of cases, the difference relating both to the concentrations and the amount secreted, compared with normal control values was significant (P greater than 0.01). But in no case was the reduced enzyme secretion so marked that one would expect maldigestion. Multivariate non-linear discriminance analysis demonstrated that pancreatic secretion in sprue is quite distinct from that in healthy subjects and those with chronic pancreatitis. It is assumed that there is a pattern of exocrine pancreatic secretion typical for sprue.
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PMID:[Pancreatic secretion in domestic sprue]. 257 24

In the jejunal mucosae of 45 children with coeliac sprue (24 cases in the florid stage and 21 cases in remission) and 19 children without signs of affection of the small intestine a quantitative investigation was made of cells in the lamina propria which were visualized selectively by histochemical and immunohistochemical methods-plasmocytes with IgA, plasmocytes with IgM, plasmocytes with IgG, cells containing IgE, mast cells, eosinophil and neutrophil leucocytes. The objective was to find which of the above cells will best reveal by a change of their number the pathological process in the lamina propria of children with coeliac sprue and which has the greatest informative value on the present state of the lamina propria. It was found that plasmocytes with IgG and cells containing IgE are good markers of the activity of coeliac sprue in the lamina propria. The best marker of the activity of coeliac sprue in the lamina propria are mast cells detected by the histochemical reaction for tryptase using Z-Ala-Ala-Lys-MNA. This reaction detects mast cells also in non-fixed bioptic material.
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PMID:[Histochemical and immunohistochemical study of jejunal mucosa cells in children with celiac sprue]. 837 76