Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.4 (
trypsin
)
42,187
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We compared pancreatic acinar and ductal secretion in two patients with
Johanson-Blizzard syndrome
, age-matched control subjects, and patients with other primary pancreatic diseases. Patients with
Johanson-Blizzard syndrome
had preservation of ductular output of fluid and electrolytes, as in patients with Shwachman syndrome but differing from those with cystic fibrosis, who have a primary ductular defect. They also had decreased acinar secretion of
trypsin
, colipase and total lipase, and low serum immunoreactive trypsinogen levels, consistent with a primary acinar cell defect.
...
PMID:Pathophysiology of the pancreatic defect in Johanson-Blizzard syndrome: a disorder of acinar development. 807 49
