Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.4 (
trypsin
)
42,187
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Treatment of porcine lymphocytes with
trypsin
reduced their spontaneous cell-mediated cytotoxicity (SCMC) activity against target cells persistently infected with transmissible gastroenteritis virus (PK15-
TGE
cells), but had no effect on antibody-dependent cell-mediated cytotoxicity (ADCC). SCMC activity was partially restored to
trypsin
-treated lymphocytes by incubation in RPMI-1640 medium or in medium containing F(ab')2 fragments of rabbit anti-porcine immunoglobulin, but not by brief incubation in autologous serum. F(ab')2 fragments of anti-porcine immunoglobulin did not block the SCMC reaction, but ADCC was greatly reduced by this reagent. Thus SCMC and ADCC mediated by porcine lymphocytes against PK15-
TGE
target cells clearly involved two distinct mechanisms in terms of antibody participation and sensitivity to
trypsin
.
...
PMID:The participation of antibody in spontaneous and antibody-dependent cell-mediated cytotoxicity in the pig. 344 94
