Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.37 (neutrophil elastase)
 4,078 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
bactericidal/permeability-increasing protein-like 1 12.9
neutrophil elastase 12.9
HCLS1 protein 11.9
HNE 11.3
Skin-derived antileukoproteinase 11.1
elastase inhibitor 11.1
cathepsin G 11.0
elafin 10.9
SERPINB1 10.8
Alpha-1 antitrypsin 10.7
PFAAP5 10.6
secretory leukocyte protease inhibitor 10.6
GAP SH3 binding protein 10.3
SPINK9 10.3
ISP2 10.3
anti-elastase 10.2
CUX1 protein 10.1
SLPI 10.1
HTF1 9.9
JAGN1 9.9
Alpha-1-antitrypsin 9.9
protein arginine deiminase 9.8
CAP37 9.8
TMPRSS11D 9.8
leukolysin 9.8
Phospholipase D4 9.8
IGG1 9.6
WFDC12 9.6
SERPINA6 9.6
metalloelastase 9.4
bomapin 9.3
serine proteinase inhibitor 9.3
MUC5AC protein 9.3
secretory leukocyte peptidase inhibitor 9.2
eppin 9.2
deleted in malignant brain tumors 1 9.2
PAO-1 9.2
matrix metalloproteinase 12 9.2
alpha-1 antitrypsin 9.2
DEFA6 9.1
proteinase 3 9.0
MMP12 9.0
HAX-1 9.0
alpha 1-antitrypsin 8.9
HP8 8.9
LRRC26 8.9
EMILIN1 8.9
PSA5 8.8
CGL-2 8.8
pancreatic elastase I 8.8
heparin-binding protein 8.8
HAX1 8.8
G6D 8.8
airway trypsin-like protease 8.8
plasminogen-like protein 8.8
N2N 8.8
WAP1 8.8
CTSC 8.7
protein-arginine deiminase 8.7
DEFA4 8.7
CAP-2 8.7
DEFA3 8.7
Alpha-1-antichymotrypsin 8.7
rBPI 8.6
ldhB 8.6
actin related protein 8.5
JFC1 8.5
mast cell protease I 8.5
preferentially expressed antigen in melanoma 8.5
G6PC3 8.4
MT6-MMP 8.3
trypsin I 8.3
AAT 8.2
Serpin 8.2
carboxypeptidase A3 8.1
cathepsin C 8.1
XDP 8.1
Gfi-1 8.1
eosinophil major basic protein 8.0
proteinase inhibitor 9 8.0
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Disease
Chronic neutrophilia 11.9
Loss of skin elasticity 11.9
Chronic epididymitis 11.3
Bronchopulmonary disease 10.9
Pseudomonas bronchitis 10.9
Bacterial infections of the respiratory tract 10.3
severe congenital neutropenia 10.3
Fibrosing colonopathy 9.8
Cyclic neutropenia 9.7
unable to stop smoking 9.6
Elastolysis 9.5
AAT deficiency 9.3
Burkholderia cepacia infection 9.1
stage II cervical cancer 9.0
Acute viral bronchiolitis 8.9
ALHE 8.8
Myelokathexis 8.6
myometritis 8.6
XDP 8.6
Heartworm disease 8.5
Chronic neutropenia 8.5
Neutrophil dysfunction 8.4
Pruritic urticarial papules and plaques of pregnancy 8.3
allergic sinusitis 8.2
autoimmune vasculitis 8.0
emphysema 7.9
Ruptured abdominal aortic aneurysm 7.8
CDA I 7.8
LUNG 7.7
Giant cell hepatitis 7.6
olfactory disorder 7.6
latent virus infection 7.5
ATRA syndrome 7.4
acute alcoholism 7.4
EDS IV 7.3
honeycomb lung 7.3
AA1 7.1
Renal scarring 7.0
Legionella pneumophila pneumonia 7.0
Laminitis 6.8
bird fancier's lung 6.8
Mevalonate kinase deficiency 6.7
ANM 6.7
EIC 6.6
Other variants 6.6
ATE 6.6
keratomalacia 6.6
c-ALL 6.6
Klebsiella pneumoniae infection 6.6
omphalitis 6.5
Metastatic colorectal cancer 6.5
Transient cerebral ischemia 6.5
adult respiratory distress syndrome 6.4
CDA II 6.4
Alveolar bone loss 6.3
pancreatic abscess 6.2
cystic fibrosis 6.2
bronchiectasis 6.2
Chronic lung disease 6.1
Thoracic aortic aneurysm 6.1
tracheobronchitis 6.1
Pseudomonas infection 6.1
Libman-Sacks endocarditis 6.1
Recurrent aphthous stomatitis 6.1
Netherton syndrome 6.0
Ehlers-Danlos syndrome type IV 6.0
Wegener's granulomatosis 5.9
Intrauterine infection 5.9
generalized tuberculosis 5.8
Gram-negative septicemia 5.8
chronic bronchitis 5.8
Diabetic complications 5.7
Griscelli syndrome 5.7
Nosocomial pneumonia 5.7
lung disease 5.7
Cohen syndrome 5.7
FAB M4 5.6
acute bronchiolitis 5.6
Maxillary sinus 5.6
vulvitis 5.6
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Symptom
inflammation of the tonsils 9.2
Air trapping 8.7
BHS 7.2
Skin symptoms 6.8
disturbed balance 6.1
bradypnea 5.3
metamorphopsia 5.0
ataxic gait 4.8
respiratory distress 4.5
Gastrointestinal symptoms 3.7
hyperoxia 3.6
microbial colonization 2.9
productive cough 2.8
Neuropathic pain 2.5
abdominal discomfort 2.2
twitching 1.9
flank pain 1.8
erythema 1.8
stridor 1.7
pallor 1.6
cough 1.6
HSA 1.4
dyspnea 1.3
colic 1.3
splenomegaly 1.2
exertional dyspnea 1.2
chills 0.9
functional recovery 0.8
anesthesia 0.7
constipation 0.6
cachexia 0.5
collapse 0.4
hypothermia 0.4
flushing 0.3
diarrhea 0.3
myalgia 0.3
dystonia -0.1
syncope -0.2
nausea and vomiting -0.3
angina -0.4
thinning -0.5
starvation -0.7
stigma -0.8
exhaustion -0.8
anorexia -0.8
Welt -1.0
chest pain -1.1
fatigue -1.1
pain -1.3
headache -1.3
nausea -1.6
overweight -1.8
analgesia -1.9
abdominal pain -2.0
weakness -2.3
seizures -3.4
Drug
Sivelestat 12.6
Sivelestat sodium hydrate 12.4
Talniflumate 10.9
Prolastin 9.9
Ulinastatin 9.6
Piclamilast 9.5
Piclamilast 9.5
Cilomilast 8.5
Camostat mesilate 8.1
Pulmozyme 7.6
Ocrelizumab 7.6
Rebamipide 7.3
Nafamostat mesilate 7.0
Hyperforin 6.9
Bexxar 6.8
Gabexate mesilate 6.7
Trifluoroethanol 6.7
Gold sodium thiomalate 6.6
Olmesartan medoxomil 6.5
Areca 6.4
Aprotinin 6.4
Atrovent 6.3
Roflumilast 5.9
Roflumilast 5.9
Antithrombin III 5.9
DFP 5.9
Enoximone 5.9
Corn oil 5.7
Daclizumab 5.4
ATV 5.4
Fragmin 5.4
Urokinase 5.2
Ipratropium bromide 5.2
ICI 5.2
Survanta 5.2
Hyaluronidase 5.1
Amrinone 5.1
Ammonium chloride 5.1
ISP 5.0
Hyaluronidase 5.0
Iloprost 4.9
G-CSF 4.8
Gelatin 4.8
Ketotifen 4.8
Nimesulide 4.7
EPI 4.7
Perindopril 4.6
Auranofin 4.5
uPA 4.5
Doxycycline 4.4
Omalizumab 4.3
Tocilizumab 4.2
ACT 4.2
Emodin 4.0
Prednisolone 4.0
LMWH 3.9
TES 3.8
Emodin 3.8
AMC 3.7
Budesonide 3.6
CFS 3.6
DNase I 3.6
CCL 3.6
Asn 3.6
NBT 3.6
Colistin 3.5
MDS 3.4
balanced salt solution 3.3
Allergen 3.3
TAT 3.3
Cimetidine 3.3
Ceftazidime 3.3
Cimetidine 3.2
Methylprednisolone 3.1
Photofrin 3.1
Monensin 3.0
Cetuximab 3.0
Sodium nitroprusside 3.0
Gel 3.0
CSF 2.9
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Enzyme
neutrophil elastase 12.9
cathepsin G 11.0
pseudolysin 11.0
macrophage elastase 10.3
proteinase-3 10.2
elastase 10.0
streptopain 9.3
aureolysin 9.3
granzyme M 9.1
neutrophil collagenase 8.8
peptidylarginine deiminase 8.1
serralysin 7.8
Streptomyces griseus protease B 7.8
alpha-lytic protease 7.7
prostasin 7.7
coagulation factor XIa 7.7
chymotrypsin 7.7
cathepsin C 7.7
chymase 7.5
PGE2 isomerase 7.3
DNase II 7.2
plasmin 7.2
tryptase 7.0
cathepsin F 6.9
C1 esterase 6.9
kallikrein 6.8
matrix metalloproteinase 9 6.7
tissue kallikrein 6.5
endoproteinase Glu-C 6.5
Hageman factor 6.5
cruzipain 6.5
matrix metalloproteinase 14 6.5
KLK7 6.4
MMP-3 6.2
cathepsin L 6.2
factor D 6.1
trypsin 6.1
interstitial collagenase 6.0
cathepsin H 6.0
cathepsin S 6.0
C3b inactivator 5.9
cathepsin B 5.9
proteinase A 5.9
meprin 5.8
CGT 5.7
cathepsin X 5.7
arachidonate 5-lipoxygenase 5.7
endoproteinase Asp-N 5.7
subtilisin 5.6
neuropsin 5.6
thrombin 5.6
matriptase 5.4
thermolysin 5.4
matrix metalloproteinase 2 5.3
collagenase 5.3
urokinase-type plasminogen activator 5.2
acetylesterase 5.2
pregnancy-associated plasma protein-A 5.2
peroxidase 5.2
arginine deiminase 5.2
papain 5.2
RGP 5.1
cathepsin K 5.1
methionine sulfoxide reductase 5.0
PPH 5.0
deoxyribonuclease 5.0
matriptase 5.0
thrombin-activatable fibrinolysis inhibitor 5.0
deoxyribonuclease 4.9
dihydropyrimidinase 4.8
NADPH oxidase 4.8
TSP-1 4.8
proteinase K 4.7
thromboplastin 4.7
granzyme B 4.7
SPT 4.7
LTA4 hydrolase 4.7
NADPH oxidase 4.7
hyaluronate lyase 4.6
tissue plasminogen activator 4.6
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Compound
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C26H28N4O9 12.9
dihydro-2(3H)-thiophenone 12.9
C26H28N4O9 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 12.9
C24H40O4 11.9
C24H40O4 11.9
Allochenodeoxycholic acid 11.3
2-phenyl-4H-3,1-benzoxazin-4-one 11.3
phenyl pivalate 11.3
Leucocyanidin 10.9
Isoursodeoxycholic acid 10.9
Agrimoniin 10.6
isodeoxycholic acid 10.6
PIMM 10.1
aminoacetic acid 10.0
aminoacetic acid 10.0
aminoacetic acid 10.0
aminoacetic acid 9.9
aminoacetic acid 9.7
isopropyl carbamate 9.7
MG 1 9.6
Hyodeoxycholic acid 9.5
S-(carboxymethyl)cysteine 8.8
S-(carboxymethyl)cysteine 8.8
isothiocyanatobenzene 8.6
ELA 8.6
ELA 8.6
3-methylisoxazole 8.4
diphenyl phosphonate 8.4
4000 M 8.3
Ritodrine hydrochloride 8.2
Ginkgetin 8.2
AAT 8.2
Actinonin 8.1
C16H14N2O2 8.1
diethyl phosphonate 8.1
S-ethylcysteine 7.6
Phenylurea 7.5
Amastatin 7.4
Elastin 7.3
diphenylsilane 7.2
Desmosine 7.2
diphenylsilane 7.2
Chymostatin 7.2
DGI 7.1
Z-Gly 7.0
Plasmin 6.9
Hyperforin 6.9
Tirofiban 6.9
2-butenoic acid 6.8
Azocoll 6.8
PAPP 6.8
octyl acetate 6.8
6-aminohexanoic acid 6.8
6-aminohexanoic acid 6.8
DCI 6.7
PAPP 6.6
2-butenoic acid 6.6
hydroxy coumarin 6.5
Cepharanthine 6.4
Kallikrein 6.4
Triolein 6.4
FMLP 6.3
CMK 6.3
SCMC 6.3
Diacetoxyscirpenol 6.3
cinnoline 6.3
Sodium deoxycholate 6.3
Serine 6.2
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