Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.37 (neutrophil elastase)
 4,078 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
neutrophil elastase 2998
HNE 828
cathepsin G 480
Sep 315
myeloperoxidase 293
Mol 269
elastin 249
chymotrypsin 233
serine protease 221
thrombin 211
alpha 1-antitrypsin 188
proteinase 3 184
protease inhibitor 164
IL-8 149
cytokine 148
Pseudomonas 138
collagen 119
granulocyte 113
lipopolysaccharide 99
elastase inhibitor 83
secretory leukocyte protease inhibitor 82
SDS 82
serine protease inhibitor 81
tumor necrosis factor 79
elafin 74
fibronectin 73
albumin 71
matrix metalloproteinase 70
glycoprotein 69
C-reactive protein 68
trypsin inhibitor 66
IL-6 65
TNF 64
MMP-9 60
serine proteinase inhibitor 59
fibrinogen 59
mucin 54
lactoferrin 50
Met 50
kallikrein 50
antithrombin III 48
urokinase-type plasminogen activator 47
plasminogen 46
chemokine 46
interleukin-6 46
collagenase 45
anti-elastase 43
alpha-1-antitrypsin 40
AAT 39
chymase 38
Alpha-1 antitrypsin 38
lysozyme 37
bradykinin 37
NMR 36
TNF-alpha 36
endoplasmic reticulum 36
metalloproteinase 35
histone 34
LPS 34
granulocyte colony-stimulating factor 33
peptidase 32
antithrombin 32
alpha-1 antitrypsin 32
antichymotrypsin 31
cathepsin B 31
factor Xa 31
proteoglycan 31
CD68 30
MMP-2 30
eosinophil cationic protein 30
insulin 29
CD11b 29
serum albumin 28
cathepsin 27
polypeptide 27
IL-1 beta 27
CD4 27
IL-10 27
mast cell 27
tissue plasminogen activator 27
IL-1 26
chymotrypsin-like 26
TLR4 26
catalase 25
p38 25
MMP-3 25
PLA 24
membrane-bound 24
COPD 24
MMP-1 24
MUC5AC 23
SLPI 23
MMP-8 23
tumor necrosis factor alpha 23
hemoglobin 22
superoxide dismutase 22
MAPK 22
alanyl 22
Alpha-1-antitrypsin 22
Skin-derived antileukoproteinase 22
Proteinase 21
esterase 21
caspase-3 21
CD8 21
ERK1 21
heparin-binding protein 21
prothrombin 20
Boc 20
MMP9 20
G-CSF 19
CSF 19
beta-thromboglobulin 19
Elastin 19
MMP12 19
lactate dehydrogenase 19
cathepsin L 19
C1 inhibitor 19
peroxidase 18
DNase 18
thromboplastin 18
thrombomodulin 18
tissue factor 18
von Willebrand factor 18
matrix metalloproteinase 2 17
CD14 17
MMP-12 17
beta-glucuronidase 17
stromelysin 17
fused 17
ICAM-1 17
histone H3 16
gut 16
lymphoid 16
intercellular adhesion molecule-1 16
Pol 16
adhesion molecule 16
interleukin 6 16
ERK 16
SERPINB1 16
EPA 15
Trypsin 15
IL-17 15
lectin 14
FMLP 14
IgA 14
ATP 14
cathepsin D 14
TOF 14
LL-37 14
G-CSF receptor 14
mast cell tryptase 14
heparin cofactor II 14
matrix metalloproteinase 9 14
interferon 13
cysteine proteinase 13
inducible nitric oxide synthase 13
cathepsin C 13
CD34 13
nerve growth factor 13
epidermal growth factor receptor 13
more...
Disease
emphysema 341
cystic fibrosis 234
chronic obstructive pulmonary disease 169
cancer 108
lung disease 107
tumor 96
sepsis 93
SDS 87
neutropenia 83
sepsis 82
severe congenital neutropenia 71
asthma 71
adult respiratory distress syndrome 61
pneumonia 60
rheumatoid arthritis 59
leukemia 53
ischemia 53
AAT deficiency 49
liver disease 42
bronchiectasis 40
periodontitis 39
SEM 36
acute myeloid leukemia 35
chronic bronchitis 35
vasculitis 34
bacterial infection 32
atherosclerosis 31
diabetes 30
psoriasis 29
Wegener's granulomatosis 27
genetic disorder 27
lung cancer 26
disseminated intravascular coagulation 26
infectious diseases 25
pulmonary edema 24
arthritis 24
COPD 24
breast cancer 22
cirrhosis 22
acute promyelocytic leukemia 22
respiratory failure 21
ulcerative colitis 20
pancreatitis 20
influenza 19
tumor growth 19
plaque 19
acute pancreatitis 19
myelodysplastic syndrome 18
mole 17
HIV 17
mole 17
carcinoma 17
hepatocellular carcinoma 17
tumor progression 16
peritonitis 16
adenocarcinoma 16
leukopenia 15
immunodeficiency 15
periodontal disease 15
inflammatory bowel disease 15
virus infection 15
stroke 14
abdominal aortic aneurysm 14
colitis 14
glomerulonephritis 14
hypertension 14
bronchiolitis 13
cold 13
malnutrition 13
tuberculosis 13
pulmonary fibrosis 13
obesity 13
myocardial ischemia 13
lung carcinoma 12
Infection 12
chronic myeloid leukemia 12
bronchitis 12
respiratory disease 12
Crohn's disease 12
bronchitis 12
systemic lupus erythematosus 12
myocardial infarction 11
autoimmune disease 11
Mycobacterium 11
idiopathic pulmonary fibrosis 11
gingivitis 10
ARF 10
thrombocytopenia 10
PAF 10
MIP 10
myeloid leukemia 10
rare disease 10
metastases 10
pemphigoid 10
PML 10
vascular disease 10
suicide 9
type 2 diabetes 9
interstitial lung disease 9
osteoarthritis 9
chronic granulomatous disease 9
Haemophilus 9
cardiovascular disease 9
Alzheimer's disease 9
schizophrenia 9
bacterial pneumonia 9
Syndrome 8
agranulocytosis 8
pancreatic cancer 8
lymphoma 8
interstitial pneumonia 8
leishmaniasis 8
pulmonary hypertension 8
squamous cell carcinoma 7
non-small cell lung cancer 7
melanoma 7
multiple sclerosis 7
proteinuria 7
DBA 7
preeclampsia 7
EPI 7
bacteremia 7
sarcoidosis 6
infertility 6
urinary tract infection 6
uterus 6
acute myocardial infarction 6
Schistosoma mansoni 6
cytomegalovirus 6
Blocking 6
coagulopathy 6
Leukemia 6
chronic liver disease 6
MCF 6
primary tumor 6
XDP 6
Evans 6
hepatitis 6
Klebsiella 6
atopic dermatitis 6
abortion 5
acute leukemia 5
sinusitis 5
renal disease 5
worms 5
panniculitis 5
heart failure 5
Mycoplasma 5
malaria 5
osteoporosis 5
type 1 diabetes 5
Wiskott-Aldrich syndrome 5
Kawasaki disease 5
anemia 5
RSV infection 5
bronchopulmonary dysplasia 5
SCID 5
gout 5
esophageal cancer 5
Cyclic neutropenia 5
more...
Symptom
respiratory distress 57
anesthesia 23
pain 14
dyspnea 9
diarrhea 9
cough 9
hyperoxia 8
erythema 6
collapse 5
splenomegaly 3
fatigue 3
hypothermia 3
headache 3
functional recovery 3
BHS 2
disturbed balance 2
starvation 2
ataxic gait 2
constipation 2
Air trapping 2
angina 2
colic 1
twitching 1
nausea 1
nausea and vomiting 1
Welt 1
exertional dyspnea 1
abdominal discomfort 1
HSA 1
metamorphopsia 1
exhaustion 1
abdominal pain 1
Skin symptoms 1
productive cough 1
anorexia 1
dystonia 1
pallor 1
stridor 1
inflammation of the tonsils 1
flushing 1
weakness 1
bradypnea 1
microbial colonization 1
overweight 1
cachexia 1
seizures 1
flank pain 1
analgesia 1
syncope 1
stigma 1
chills 1
Gastrointestinal symptoms 1
thinning 1
Neuropathic pain 1
myalgia 1
chest pain 1
Drug
lysine 49
Dermatol 45
Sivelestat 37
CSF 30
Cardiovasc 25
ICI 25
G-CSF 19
Asn 18
Sivelestat sodium hydrate 17
Gel 15
DNase I 13
Ulinastatin 11
IL-2 11
Aprotinin 10
IFN-gamma 9
ROS 8
DFP 7
Asthma 7
ENT 7
EPI 7
Nephron 6
Nephron 6
vitamin E 6
Gelatin 6
uPA 6
ACT 5
Prolastin 5
CaCl2 4
MAP 4
CaCl2 4
ABC 4
CaCl2 4
Albumin 4
Dial 4
ascorbate 4
Antithrombin III 4
citric acid 3
Biopolymers 3
Areca 3
Glutathione 3
TAT 3
MDS 3
Doxycycline 3
Prednisolone 3
Urokinase 3
Rebamipide 3
Hyperforin 2
Allergen 2
Cilomilast 2
Indomethacin 2
balanced salt solution 2
Alanine 2
Fluorescein 2
CAM 2
NBT 2
Monit 2
CCL 2
Cimetidine 2
ATV 2
Hyaluronidase 2
AMC 2
Ringer's solution 2
Histamine 2
ROC 2
nitroglycerin 2
Herceptin 2
Cimetidine 2
Iloprost 2
ISP 2
Hyaluronidase 2
Fluorescein 2
Enoximone 1
niacin 1
p75 1
Auranofin 1
Ocrelizumab 1
Bayer 1
Paraffin 1
DHT 1
CTA 1
AZT 1
Serum albumin 1
Pronase 1
Emodin 1
Cetuximab 1
Gold sodium thiomalate 1
Bortezomib 1
CTC 1
lactose 1
Ammonium chloride 1
Trifluoroethanol 1
L-tyrosine 1
Parkin 1
LMWH 1
Hypaque 1
Sodium nitroprusside 1
ampicillin 1
Photofrin 1
Leaf 1
Methylprednisolone 1
Azithromycin 1
Ipratropium bromide 1
Kenyan 1
CFS 1
Infliximab 1
Monensin 1
Omalizumab 1
Bexxar 1
Nimesulide 1
TTC 1
Daclizumab 1
Amrinone 1
Bifidobacterium 1
Tocilizumab 1
Atrovent 1
Pulmozyme 1
Gefitinib 1
Parkin 1
Rituximab 1
Talniflumate 1
TES 1
Roflumilast 1
EPA 1
IL-11 1
Ketotifen 1
Piclamilast 1
Retinoic acid 1
Ceftazidime 1
Corn oil 1
Colistin 1
Hypaque 1
Simvastatin 1
PCB 1
Budesonide 1
Roflumilast 1
CTC 1
Olmesartan medoxomil 1
Piclamilast 1
Vitamin E 1
Camostat mesilate 1
Emodin 1
DHT 1
Glycyrrhiza 1
Nafamostat mesilate 1
Fragmin 1
Perindopril 1
Survanta 1
Gabexate mesilate 1
Enzyme
neutrophil elastase 4078
elastase 1231
cathepsin G 470
trypsin 374
peroxidase 310
chymotrypsin 286
thrombin 206
plasmin 165
collagenase 90
kallikrein 86
mitogen-activated protein kinase 54
proteinase-3 53
urokinase-type plasminogen activator 52
tryptase 47
thromboplastin 45
aspartate aminotransferase 39
NADPH oxidase 37
NADPH oxidase 37
lysozyme 37
tissue plasminogen activator 36
MMP-3 33
cathepsin B 32
chymase 32
ERK 31
papain 30
matrix metalloproteinase 9 29
catalase 28
subtilisin 28
APC 26
protein kinase C 26
DNase 23
macrophage elastase 23
superoxide dismutase 23
cathepsin L 19
pseudolysin 19
lactate dehydrogenase 19
caspase-3 17
beta-glucuronidase 16
alanine aminotransferase 16
tissue kallikrein 15
proteinase K 14
proteasome 13
CD10 13
cathepsin D 13
peptidylarginine deiminase 13
protein kinase 12
phosphodiesterase 12
pepsin 12
matrix metalloproteinase 2 12
neutrophil collagenase 11
caspase-1 11
reverse transcriptase 11
granzyme B 11
xanthine oxidase 11
MMP 10
MIP 10
thermolysin 10
cathepsin C 10
alkaline phosphatase 9
transglutaminase 9
lipase 9
endonuclease 9
phospholipase A2 9
cathepsin K 8
DNase II 8
phospholipase C 8
interstitial collagenase 8
hyaluronidase 8
ACS 7
creatine kinase 7
luciferase 7
chloramphenicol acetyltransferase 6
deoxyribonuclease 6
deoxyribonuclease 6
Hageman factor 6
RNA polymerase 6
RNase 6
hyaluronidase 6
focal adhesion kinase 6
caspase-9 5
NO synthase 5
RNase 5
acetylcholinesterase 5
BAL 5
cruzipain 5
enolase 5
endoproteinase Glu-C 5
cathepsin S 4
aureolysin 4
factor D 4
ceruloplasmin 4
PNGase F 4
glucose oxidase 4
arginine deiminase 4
meprin 4
ACE 4
prostasin 4
lipoxygenase 3
cathepsin H 3
deaminase 3
transcriptase 3
AMP-activated protein kinase 3
MEK 3
CGT 3
prostate-specific antigen 3
beta-lactamase 3
TSP-1 3
alpha-lytic protease 3
TAT 3
chondroitinase 3
caspase-8 3
chondroitinase 3
SPT 3
heparinase 3
NOS 3
PARP 2
streptopain 2
MAP 2
ribonuclease 2
leucine aminopeptidase 2
phosphatidylinositol 3-kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
serralysin 2
sialyltransferase 2
C3b inactivator 2
endoglycosidase H 2
sialyltransferase 2
sialyltransferase 2
ribonuclease 2
thymidine kinase 2
carbonic anhydrase 2
matriptase 2
phosphoinositide 3-kinase 2
gamma-glutamyl transpeptidase 2
calcineurin 2
furin 2
dipeptidyl peptidase IV 2
KLK7 2
proteinase A 2
acid phosphatase 2
renin 2
glyceraldehyde-3-phosphate dehydrogenase 2
factor C 2
S1 nuclease 2
micrococcal nuclease 2
tyrosinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
alpha-glucosidase 2
neuraminidase 2
adenylate cyclase 2
glutathione peroxidase 2
hexosaminidase 2
alpha-mannosidase 2
matriptase 2
granzyme M 2
DNA polymerase 2
PPH 1
alpha-amylase 1
more...
Compound
serine 521
Dec 306
DNA 255
Clin 244
oxygen 189
alanine 172
Phe 121
sodium 117
methionine 107
acetate 103
leucine 100
sulfate 96
arginine 95
calcium 89
SDS 88
lysine 81
water 66
TNF 64
valine 57
cysteine 57
His 46
hydrogen 42
salt 41
tyrosine 40
NH2 39
Gly 35
Pac 35
nitrogen 33
phosphate 32
AAT 32
Ile 32
H2O2 32
Serine 32
nitric oxide 28
Asp 27
EDTA 26
EDTA 26
Heparin 26
ICI 25
glucose 24
threonine 23
proline 23
PMA 22
urea 22
PMA 20
retinoic acid 20
Thrombin 19
Elastin 19
hyaluronic acid 17
PEG 16
tryptophan 16
tryptophan 16
ammonium 16
tryptophan 16
tryptophan 16
Trypsin 15
prostacyclin 15
creatinine 15
TOF 14
ATP 14
chromate 14
zinc 13
ADP 13
Plasmin 12
glutamic acid 12
FMLP 12
THP 12
THP 12
HCl 12
ethanol 11
PEG 11
acetic acid 11
ACS 11
CO2 10
copper 10
PMSF 10
guanidine 9
prostaglandin E1 9
ADP 9
galactose 9
benzene 9
ADP 9
cAMP 9
TCA 8
superoxide radical 8
ELA 8
C-3 8
ELA 8
iron 7
ACS 7
BAL 7
DEAE 7
aldehyde 7
hydroxylamine 7
acetone 7
aldehyde 7
methanol 7
COS 7
NADPH 7
bromide 7
hydroxylamine 7
NADPH 7
acrylamide 7
Collagen 7
Kallikrein 7
N-acetylcysteine 6
2-hydroxyethyl 6
Triton X-100 6
2-hydroxyethyl 6
DBA 6
DBA 6
2-hydroxyethyl 6
2-hydroxyethyl 6
GSH 6
glutamine 6
neopterin 6
2-hydroxyethyl 6
Salt 6
DBA 6
2-hydroxyethyl 6
E-64 6
isoleucine 6
isoleucine 6
2-hydroxyethyl 6
asparagine 6
GSH 6
Fibrinogen 6
2-hydroxyethyl 6
CMK 6
MDA 5
Phorbol 5
vinyl 5
formaldehyde 5
MTT 5
aminoacetic acid 5
benzoic acid 5
aminoacetic acid 5
aminoacetic acid 5
Cardiol 5
aminoacetic acid 5
dUTP 5
DAD 5
hydroxide 5
Fibrin 5
ethyl acetate 5
Tris 5
aminoacetic acid 5
norleucine 4
norvaline 4
6-aminohexanoic acid 4
ANCA 4
CAT 4
SCN 4
FDP 4
formaldehyde 4
Verapamil 4
sodium chloride 4
Dexamethasone 4
DMSO 4
DTT 4
more...