Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.37 (
neutrophil elastase
)
4,078
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Several peptidyl thiocarbamate inhibitors of human
leukocyte elastase
were synthesized in the molecular weight range of 700-800. Two different sequences with lysine at the P3 and
ornithine
at the P4 positions were synthesized. Most of the inhibitors with large molecular weights showed high inhibitory capacity with Ki values as low as 10(-8)M. Compounds immobilized on poly,alpha,beta-[N-(2-hydroxyethyl)-D,L-aspartamide] (PHEA) polymers with an average molecular weight of 36,000 showed higher inhibitory capacity than their free forms.
...
PMID:Synthesis and mechanism of action of novel thiocarbamate inhibitors of human leukocyte elastase. 1085 Sep 55
Several peptidyl thiocarbamate inhibitors of human
leukocyte elastase
were synthesized in the molecular weight range of 700-800. Two different sequences with lysine at the P(3) and
ornithine
at the P(4) positions were synthesized. Most of the inhibitors with large molecular weights showed high inhibitory capacity with Ki values as low as 10(-8) M. Compounds immobilized on poly,alpha,beta-[N-(2-hydroxyethyl)-d,l-aspartamide] (PHEA) polymers with an average molecular weight of 36,000 showed higher inhibitory capacity than their free forms.
...
PMID:Synthesis and Mechanism of Action of Novel Thiocarbamate Inhibitors of Human Leukocyte Elastase. 1093 34
