Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.1 (chymotrypsin)
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Human Gene/Protein
CTRL protein 11.5
protein DDX26B 11.5
MiIX 11.5
chymotrypsin 11.4
elastase 2A 10.7
aminopeptidase O 10.5
branched chain alpha-ketoacid dehydrogenase kinase 10.5
HLA-DRB1 protein 10.5
amyloid protein AL 10.5
Chymotrypsin 10.5
pancreatopeptidase E 10.2
SPINK9 9.9
protease E) 9.9
testis-specific serine protease 1 9.9
Serine proteinase inhibitor 9.8
elastase 3B 9.7
GRP-preferring bombesin receptor 9.5
GTP-binding protein Rab5 9.5
LPHA 9.5
AB18 9.5
Kinase-related protein 9.5
MC-CPA 9.5
CT47 9.2
probable transposase 9.2
chymotrypsin-like protease 9.2
mast cell protease I 9.0
cathepsin L-like protein 8.9
F379 8.9
SERP2 8.9
TMEM114 8.9
MMSDH 8.9
trypsin I 8.9
skin tryptase 8.8
CTRB1 8.8
Carboxypeptidase A 8.7
chymotrypsin-like 8.7
PLC-III 8.7
proteinase inhibitor 8 8.7
cystatin-like molecule 8.7
AP3D1 8.7
G11A 8.7
C4a anaphylatoxin 8.7
CTRB2 8.7
pregnancy zone protein 8.7
ovostatin 8.6
Trypsin-2 8.6
pancreatic elastase 1 8.5
trypsin 1 8.5
HP8 8.5
HTF1 8.5
tubulin alpha chain 8.5
cathepsin G 8.5
Carboxypeptidase B 8.5
pancreatic elastase I 8.4
tissue factor pathway inhibitor-2 8.4
myosin IA 8.4
MTJ1 8.3
MDP-1 8.3
alpha 1,6-fucosyltransferase 8.3
Trypsin 8.3
trypsin inhibitor 8.3
PI7 8.2
Peptidyl-prolyl cis-trans isomerase 8.2
SERPINB13 8.2
Formiminotransferase-cyclodeaminase 8.2
Fibroblast growth factor 7 8.2
Pancreatic elastase 8.2
tfp 8.2
serine protease homologue 8.2
elastase 1 8.1
glycophorin B 8.1
lysophospholipase II 8.1
serine proteinase inhibitor 8.1
SPINK2 8.0
Hexokinase type I 8.0
granzyme H 8.0
serpin-like protein 8.0
headpin 8.0
OXSR1 8.0
pregastric lipase 8.0
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Disease
Subclinical diabetes 11.5
familial hypothyroidism 9.9
Peripancreatic necrosis 9.5
Pancreatic steatorrhea 9.2
Alcoholic liver damage 9.2
syphilid 8.3
COND 7.8
Acute glaucoma 7.8
Ehlers-Danlos syndrome type VII 7.6
Ligneous conjunctivitis 7.4
pancreatic insufficiency 7.4
EA4 7.2
MF4 6.9
Lederer 6.8
AD10 6.8
Clear cell chondrosarcoma 6.8
disaccharidase deficiency 6.7
blind loop syndrome 6.5
EPPS 6.3
Clostridium perfringens infection 6.3
steatorrhea 6.1
Takahara 6.0
intestinal neoplasm 6.0
Acinar cell carcinoma 6.0
Enzyme inhibition 5.8
Shope papilloma 5.8
ovarian mucinous cystadenocarcinoma 5.8
HSAN1 5.7
BDB 5.7
thrombopathy 5.6
Southeast Asian ovalocytosis 5.6
ocular hypertension 5.5
Glanzmann's thrombasthenia 5.5
Mevalonate kinase deficiency 5.3
EIC 5.2
chronic pancreatitis 5.2
ATE 5.2
Bernard-Soulier syndrome 5.2
Ectopic pancreas 5.1
SDS 5.0
CDA II 5.0
proctosigmoiditis 4.9
louping ill 4.9
Murine typhus 4.8
Solid pseudopapillary tumor 4.8
MNS 4.7
Necrotic enteritis 4.7
childhood glaucoma 4.7
RHS 4.7
alcoholic pancreatitis 4.6
pancreatic neoplasm 4.6
hypoprothrombinemia 4.6
Duodenum 4.6
Duodenum 4.6
Pancreatic duct 4.6
Pancreas 4.6
SM1 4.6
Pancreas 4.5
PanIN 4.5
gastric neoplasm 4.5
leeches 4.4
Lowe 4.4
carcinoma of the pancreas 4.4
Aleutian disease 4.3
EMD 4.3
Ileum 4.3
poison ivy 4.3
mouse leukemia L1210 4.3
IgG myeloma 4.2
DIP 4.2
ISD 4.2
Copper deficiency 4.2
tropical sprue 4.1
SDA 4.1
Juvenile xanthogranuloma 4.1
Aspartylglucosaminuria 4.0
lymphangiectasis 4.0
acute pancreatitis 4.0
LPI 4.0
Murray Valley encephalitis 3.9
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Symptom
Local swelling 7.8
autodigestion 6.4
change in stool 6.3
PAIN 5.4
Blanching 4.8
Spots 4.7
scaly skin 4.1
Halo 2.7
rundown 2.5
eds 2.5
Gastrointestinal symptoms 2.3
HSA 2.3
bitter taste 2.0
microbial colonization 1.5
hypoproteinemia 1.4
flushing 1.2
Wind 1.2
cachexia 1.0
skin damage 0.9
starvation 0.9
agitation 0.8
abdominal discomfort 0.8
diarrhea 0.6
tremor 0.5
heartburn 0.5
skin irritation 0.4
tense 0.4
flank pain 0.4
stigma 0.4
stridor 0.3
collapse 0.3
acidity 0.2
tachypnea 0.2
erythema 0.1
regurgitation 0.1
lethargy 0.0
paresis -0.0
hoarseness -0.0
abdominal pain -0.1
epigastric pain -0.2
memory loss -0.3
acute pain -0.4
wheezing -0.7
respiratory distress -0.8
constipation -0.8
hyperoxia -0.8
thinning -1.0
hunger -1.0
nausea -1.0
tinnitus -1.2
exhaustion -1.2
anorexia -1.2
spasm -1.3
vomiting -1.5
hypothermia -1.6
dizziness -1.7
pain -1.8
Ill -1.9
ataxia -2.4
Welt -2.5
discomfort -2.9
discomfort -3.1
fatigue -3.2
anesthesia -3.2
dyspnea -3.3
seizures -4.8
Drug
Proflavin 8.2
Benzenesulfonyl 8.2
Methacholine chloride 8.0
Z-Pro-Prolinal 7.8
Trazodon 7.7
Methyltyrosine 7.7
Formycin 7.7
Pronase 7.3
Papain 7.1
L-tyrosine 6.9
Tepoxalin 6.9
Tora 6.8
Trusopt 6.7
Protein hydrolysate 6.6
Aprotinin 6.5
Bromelain 6.4
DFP 6.4
Trifluoroethanol 6.2
Pancrease 6.1
Myotrophin 6.1
Secretin 6.0
Cardizem CD 5.9
Span 40 5.9
Sodium carbonate 5.8
Pancreatin 5.7
Ulinastatin 5.7
Sodium citrate 5.7
Sodium citrate 5.7
Tenecteplase 5.6
Loxiglumide 5.6
Dopexamine 5.5
Pyridoxal phosphate 5.4
Cremophor RH40 5.3
Ceredase 5.3
AMC 5.3
Gabexate mesilate 5.3
Timolol maleate 5.1
Timolol 5.1
Cobalamin 5.0
Deuterium oxide 5.0
Cibacron Blue 4.9
PFT 4.9
CG1 4.9
Carbopol 934P 4.8
Asn 4.8
Cerezyme 4.8
Carbopol 934 4.8
NBT 4.7
Flavin 4.7
Protamine sulfate 4.6
Acacia 4.5
Pyridoxal 4.5
Antithrombin III 4.5
Geranium 4.5
Span 20 4.5
Phosphatidylserine 4.4
Zein 4.4
Gel 4.3
Enalaprilat 4.3
Hyaluronidase 4.3
FLM 4.3
Enalaprilat 4.2
Lactic Acid 4.2
Hyaluronidase 4.1
Guanidine 4.1
Guanidine 4.1
Quisqualate 4.0
Fragment 4.0
APM 4.0
Salmon calcitonin 4.0
lysine 4.0
Tao 3.9
Nedocromil sodium 3.9
Carbenoxolone 3.9
SMP 3.9
Tween 40 3.9
Doyle 3.9
Lupron 3.8
R1881 3.8
NAG 3.8
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Enzyme
chymotrypsin 11.5
pyrrolooxygenase 11.5
Leu-proteinase 10.9
GluSGP 10.5
Scytalidium lignicolum acid proteinase 10.5
brachyurin 10.5
Sindbis virus core protein 9.9
EC 3.2.1.70 9.9
Streptomyces griseus protease B 9.8
pancreatic elastase 2 9.7
chymotrypsin C 9.6
coagulation factor XIa 9.4
glycolaldehyde dehydrogenase 9.2
ficin 9.0
alpha-lytic protease 8.9
duodenase 8.9
cucumisin 8.8
RVV-V 8.8
thermolysin 8.7
clostripain 8.7
proteinase yscD 8.7
endoproteinase Glu-C 8.6
trypsin 8.6
cathepsin G 8.6
phosphoamidase 8.5
subtilisin 8.5
endopeptidase I 8.5
carboxypeptidase A 8.5
hypodermin C 8.4
spermosin 8.3
elastase 8.3
carboxypeptidase S 8.3
papain 8.1
actinase E 8.0
thermitase 8.0
phytepsin 7.9
bromelain 7.9
lysyl endopeptidase 7.9
stratum corneum chymotryptic enzyme 7.8
endoproteinase Asp-N 7.7
pepsin 7.7
neutrophil elastase 7.7
carboxypeptidase B 7.6
N-acetylglucosaminyltransferase IV 7.6
stem bromelain 7.6
NS protease 7.5
CBPP 7.5
lactaldehyde dehydrogenase 7.4
proteinase A 7.4
chondro-4-sulfatase 7.3
proteinase K 7.3
chymase 7.2
enterokinase 7.1
acrosin 7.1
pipecolate oxidase 7.0
KLK7 7.0
BCKDH 7.0
tissue kallikrein 6.9
trans-2-enoyl-CoA reductase 6.9
kallikrein 6.8
leucine aminopeptidase 6.8
plasmin 6.8
lactaldehyde dehydrogenase 6.7
granzyme M 6.6
prolyl endopeptidase 6.6
prostasin 6.6
endothiapepsin 6.6
GTF-S 6.6
protein methylase I 6.6
C1 esterase 6.4
alanine aminopeptidase 6.4
6-hydroxy-D-nicotine oxidase 6.4
cathepsin C 6.4
proteinase A 6.3
bromelin 6.3
carboxyl proteinase 6.3
pseudolysin 6.3
carboxypeptidase II 6.3
dimethylglycine dehydrogenase 6.2
neuropsin 6.2
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Compound
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
ethyl hentriacontanoate 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
C24H40O4 11.5
dihydro-2(3H)-thiophenone 11.5
C24H40O4 10.5
Tetraethylene glycol 10.5
Ac-Tyr-OEt 10.5
4-Methylumbelliferyl acetate 10.5
Salcomine 10.5
C24H40O4 10.5
Allochenodeoxycholic acid 9.9
C10H8O2 9.9
7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 9.9
3-bromopropanoic acid 9.9
Isoursodeoxycholic acid 9.5
isodeoxycholic acid 9.2
C5H6O4 9.2
Orange IV 8.9
C20H24N2O4 8.9
Cyclohexyl isocyanate 8.9
2,1-benzisoxazole 8.7
trifluoroisoleucine 8.7
benzenecarboximidamide 8.7
2-naphthyl acetate 8.6
TPCK 8.6
Chymostatin 8.6
N-Acetyl-L-tyrosine 8.5
alpha-Amyrin 8.5
Neoprontosil 8.5
N-acetylphenylalanine 8.5
N-acetylphenylalanine 8.5
Trypsin 8.3
2-oxohexanoic acid 8.2
Petasin 8.2
C9H11NO2 8.2
Eugeniin 8.2
Z-Gly 8.2
Hyodeoxycholic acid 8.0
4-benzoylbenzoic acid 8.0
diphenyl phosphonate 8.0
C9H11NO2 7.9
Z-Gly-Pro 7.8
Methacrylamide 7.8
Azocoll 7.7
Cytochrome c1 7.7
p-Nitrophenyl acetate 7.7
1H-phenalen-1-one 7.6
Sodium glycocholate 7.6
S-benzylcysteine 7.5
S-benzylcysteine 7.5
1-triacontanol 7.4
Metaxalone 7.4
Endothall 7.4
GABOB 7.4
RBr 7.3
2-methylaziridine 7.3
N-acetyltryptophan 7.2
Azocasein 7.2
Trinitrobenzenesulfonic acid 7.2
N-acetyltryptophan 7.2
S-ethylcysteine 7.2
PABA 7.1
S-benzylcysteine 7.1
Butylidenephthalide 7.0
2-aminobutanoic acid 7.0
Aurin 7.0
PMSF 7.0
4-aminophenylalanine 6.9
A-500 6.9
4000 M 6.9
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