Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.1 (chymotrypsin)
 10,938 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
chymotrypsin 8983
Sep 765
polypeptide 622
Mol 587
SDS 569
trypsin inhibitor 537
thrombin 479
serine protease 463
amylase 441
lipase 436
Trypsin 354
Chymotrypsin 335
glycoprotein 283
NMR 256
chymotrypsin-like 247
protease inhibitor 245
casein 235
ATP 232
cathepsin G 229
serum albumin 219
lysozyme 210
insulin 204
neuraminidase 191
inhibitor 2 185
collagen 173
collagenase 170
gut 166
kallikrein 164
Met 157
mast cell 155
fibrinogen 152
neutrophil elastase 149
secretin 144
proteasome 136
HNE 132
esterase 131
ATPase 127
peptidase 127
albumin 119
serine protease inhibitor 116
cholecystokinin 114
myosin 113
ADP 111
factor Xa 105
alkaline phosphatase 102
urokinase-type plasminogen activator 88
antichymotrypsin 83
dimeric 82
catalase 81
membrane-bound 81
TOF 80
heavy chain 80
alpha-amylase 79
lectin 79
alpha 1-antitrypsin 78
threonine 78
Gen 76
trypsinogen 74
fibronectin 73
chymase 72
cathepsin B 72
calmodulin 72
Pseudomonas 70
membrane protein 69
hemoglobin 68
AMP 67
serine proteinase inhibitor 66
cytochrome c 65
leucine aminopeptidase 65
aminopeptidase 63
cathepsin D 62
PEG 61
fused 60
ESI 59
ubiquitin 58
microsomal 56
Proteinase 56
bradykinin 55
peroxidase 52
myoglobin 51
PLA 50
GTP 49
elastin 49
endoplasmic reticulum 48
adenylate cyclase 47
CCK 46
phospholipase A2 46
prothrombin 46
phosphatase 46
IgE 46
renin 45
urinary kallikrein 45
Boc 44
cysteine protease 44
plasminogen 44
RNase 44
substance P 43
carboxypeptidase B 41
histone 40
proteoglycan 39
hole 39
alanyl 38
thymus 38
epidermal growth factor 38
PGA 38
chymotrypsin-like protease 38
hyaluronidase 38
antithrombin III 38
acetylcholinesterase 37
glucagon 37
spermatozoa 36
lactate dehydrogenase 36
Pol 36
brush border 36
cytochrome 35
cytokine 35
carp 35
SOD 35
mucin 35
superoxide dismutase 34
vasoactive intestinal peptide 34
acid phosphatase 32
dilute 32
glucosamine 32
metalloprotease 32
ACR 32
calpain 32
glucocorticoid receptor 32
P2' 31
pancreatic lipase 31
amyloid precursor protein 31
thromboplastin 30
somatostatin 30
cysteine proteinase 30
lipopolysaccharide 29
vasoactive intestinal peptide (VIP) 29
protein C 29
tissue plasminogen activator 29
GPIIb 29
mer 28
alpha2-macroglobulin 28
transferrin 28
carbonic anhydrase 27
angiotensin II 27
antithrombin 26
alpha-1-antitrypsin 26
C-terminal peptide 26
C18 26
NAD 26
ribonuclease A 26
beta 1 26
ACS 26
glucosidase 26
hinge 26
cAMP-dependent protein kinase 26
elastase inhibitor 25
tissue factor 25
type I collagen 25
alcohol dehydrogenase 25
enterokinase 24
more...
Disease
SDS 570
cancer 188
tumor 186
chronic pancreatitis 91
pancreatic insufficiency 89
pancreatitis 68
Alzheimer's disease 63
carcinoma 59
Pancreas 58
acute pancreatitis 58
Pancreas 57
cystic fibrosis 54
leukemia 44
intraocular pressure 41
mole 41
mole 41
diabetes 39
hepatocellular carcinoma 37
NAME 37
malaria 36
breast cancer 35
MCF 34
cold 33
plaque 33
HIV 32
adenocarcinoma 31
prostate cancer 29
glaucoma 28
steatorrhea 28
uterus 28
ocular hypertension 27
carcinogenesis 26
hypertension 25
SEM 25
depression 24
malabsorption 23
multiple myeloma 22
Mycobacterium 21
melanoma 21
lymphoma 21
GSH 21
celiac disease 19
cholera 19
immunodeficiency 19
pertussis 18
Klebsiella 18
dehydration 18
metastases 18
fits 18
aqueous humor 17
pancreatic cancer 17
SARS 17
rheumatoid arthritis 16
neuroblastoma 16
suicide 16
worms 16
influenza 16
emphysema 15
cataract 14
tuberculosis 14
Schistosoma mansoni 14
Glanzmann's thrombasthenia 14
sarcoma 13
malnutrition 13
hepatitis B 13
gonococcal 13
ash 13
Dissociation 12
glioma 12
tumor growth 12
cornea 12
West 11
infectious diseases 11
virus infection 11
asthma 11
sepsis 10
Bernard-Soulier syndrome 10
ischemia 10
NS3 10
cytomegalovirus 10
gastroenteritis 10
atherosclerosis 10
EMD 10
Infection 9
stomatitis 9
anthrax 9
Yersinia 9
cirrhosis 9
PSA 9
Parkinson's disease 9
liver disease 9
herpes simplex 9
thrombocytopenia 9
PAF 9
vaccinia 9
malignant fibrous histiocytoma 9
Blocking 9
AIDS 8
lung cancer 8
glioblastoma 8
colon cancer 8
MRS 8
sepsis 8
dengue 8
Bordetella 8
herpes zoster 8
Best 8
acute myocardial infarction 8
PDB 8
carcinoma of the pancreas 8
Adhesion 8
preeclampsia 8
EDC 8
periodontitis 7
giardiasis 7
encephalitis 7
squamous cell carcinoma 7
disseminated intravascular coagulation 7
Brown 7
PAA 7
TEM 7
leeches 7
anaphylaxis 7
chronic obstructive pulmonary disease 7
Haemophilus 7
alcoholism 7
Rous sarcoma 6
arthritis 6
Down syndrome 6
Placenta 6
Spleen 6
Proteus 6
colitis 6
colorectal cancer 6
tumor progression 6
SAR 6
mouth disease 6
fungal infection 6
erythroleukemia 6
infertility 6
TEM 6
enteritis 6
von Willebrand disease 6
RCM 6
Epstein 6
idiopathic thrombocytopenic purpura 6
Chlamydia 6
dementia 6
hepatitis C 6
osteogenesis imperfecta 6
Crohn's disease 6
tumorigenesis 6
Frey 6
cervical cancer 6
renal failure 6
primary tumor 6
lung disease 6
multiple endocrine neoplasia 6
obesity 5
epididymis 5
more...
Symptom
diarrhea 29
pain 25
starvation 16
collapse 12
abdominal pain 10
autodigestion 9
tremor 9
agitation 7
acidity 6
stigma 6
flushing 5
HSA 5
erythema 5
anesthesia 4
respiratory distress 4
nausea 4
vomiting 4
cachexia 4
Spots 4
regurgitation 3
thinning 2
exhaustion 2
constipation 2
bitter taste 2
eds 2
lethargy 2
anorexia 2
paresis 2
fatigue 2
hypothermia 2
Wind 2
microbial colonization 1
wheezing 1
seizures 1
hoarseness 1
tinnitus 1
discomfort 1
acute pain 1
heartburn 1
ataxia 1
abdominal discomfort 1
PAIN 1
scaly skin 1
epigastric pain 1
Welt 1
Local swelling 1
hyperoxia 1
Blanching 1
Halo 1
hunger 1
dizziness 1
change in stool 1
dyspnea 1
discomfort 1
skin damage 1
memory loss 1
stridor 1
tense 1
rundown 1
tachypnea 1
Ill 1
Gastrointestinal symptoms 1
spasm 1
hypoproteinemia 1
skin irritation 1
flank pain 1
Drug
lysine 314
Asn 116
Gel 102
L-tyrosine 97
Pronase 72
Dermatol 33
Aprotinin 29
Papain 27
CaCl2 26
CaCl2 26
DFP 26
CaCl2 26
DNase I 24
NADH 23
Leaf 22
ABC 21
FAD 16
Secretin 16
AMC 16
lactose 16
ascorbate 15
Biopolymers 14
Fragment 13
Acacia 13
NBT 12
Cardiovasc 11
Capsicum 10
IFN-gamma 10
NAG 10
pyridoxal phosphate 10
CSF 10
IL-2 10
Fraction 9
MAP 8
ACT 8
PTC 8
NH3 7
PTH 7
Nephron 7
Alanine 6
Albumin 6
uPA 6
Indomethacin 6
CDP 6
Gelatin 5
Bromelain 5
Timolol 5
PFT 5
Fluorescein 5
Phosphatidylserine 5
HCH 5
Fluorescein 5
Cibacron Blue 5
TiO2 4
Histamine 4
Methylene blue 4
Antithrombin III 4
FeCl3 3
Ouabain 3
Atropine 3
Bifidobacterium 3
balanced salt solution 3
Cobalamin 3
MRC 3
Glucagon 3
Flavin 3
vitamin E 3
ZnO 3
PCP 3
ROS 3
Bortezomib 3
Hyaluronidase 3
ampicillin 3
Vitamin B12 3
R1881 3
Ethanol 3
p75 3
Ringer's solution 3
citric acid 3
Hyaluronidase 3
caffeine 3
BH4 2
Guanidine 2
Nephron 2
Angiotensin II 2
Dial 2
Pyridoxal 2
-deoxyadenosine 2
Geranium 2
Bayer 2
Luteinizing 2
Riboflavin 2
PDL 2
OMP 2
CTX 2
Sodium citrate 2
Silica 2
Sodium citrate 2
SMP 2
Nitric Oxide 2
Ulinastatin 2
SiO2 2
Sodium nitroprusside 2
ZnCl2 2
ZnCl2 2
Tao 2
Pyridoxal phosphate 2
IFN-beta 2
CIA 2
Lovastatin 2
Glutathione 2
Guanidine 2
THF 2
Camp 2
Urokinase 2
Vitamin B 2
Asthma 2
EPA 2
Pilocarpine 2
Doyle 2
Trifluoroethanol 2
Zein 2
Itraconazole 2
Benzenesulfonyl 1
NVP 1
Parkin 1
Carbopol 934 1
AraC 1
Carbopol 934P 1
Lupron 1
DHT 1
Mutagen 1
Check 1
Ranitidine 1
Orlistat 1
CG1 1
Z-Pro-Prolinal 1
CTA 1
Allergen 1
Tannic acid 1
Taxol 1
Deuterium oxide 1
Enalaprilat 1
Dopexamine 1
Methyltyrosine 1
Metrizamide 1
nitroglycerin 1
Adenosine triphosphate 1
Myotrophin 1
ADR 1
Parkin 1
NovoSeven 1
ETA 1
Tenecteplase 1
MOF 1
SBT 1
Captopril 1
Adriamycin 1
Sodium carbonate 1
ROC 1
more...
Enzyme
chymotrypsin 10938
trypsin 5478
elastase 1007
pepsin 612
papain 601
subtilisin 559
thrombin 478
lipase 437
plasmin 351
neutrophil elastase 286
thermolysin 276
kallikrein 238
cathepsin G 234
proteinase K 225
lysozyme 213
neuraminidase 201
collagenase 178
proteasome 161
ATPase 137
thromboplastin 131
carboxypeptidase A 119
RNase 116
RNase 105
alkaline phosphatase 103
protein kinase 96
urokinase-type plasminogen activator 94
peroxidase 93
alpha-amylase 87
bromelain 84
catalase 83
cathepsin B 72
phospholipase A2 69
CD10 68
chymase 66
ribonuclease 66
ribonuclease 64
leucine aminopeptidase 64
ficin 61
cathepsin D 59
endoproteinase Glu-C 57
tissue kallikrein 53
hyaluronidase 52
acetylcholinesterase 51
ACE 48
adenylate cyclase 47
alpha-glucosidase 47
APC 47
lactate dehydrogenase 46
DNase 46
phospholipase C 45
renin 45
tryptase 44
tissue plasminogen activator 43
carboxypeptidase B 42
lysyl endopeptidase 40
superoxide dismutase 40
deaminase 39
hyaluronidase 38
acid phosphatase 36
clostripain 36
beta-galactosidase 35
carboxylesterase 35
cholinesterase 33
glutathione S-transferase 32
invertase 32
enterokinase 32
acrosin 31
carboxypeptidase Y 30
AMPK 29
reverse transcriptase 29
alcohol dehydrogenase 29
prolyl endopeptidase 27
protein kinase C 27
carbonic anhydrase 27
RNA polymerase 27
ACS 26
urease 25
phosphodiesterase 25
urease 25
sucrase 24
creatine kinase 22
cathepsin L 22
beta-glucosidase 21
alanine aminopeptidase 21
gamma-glutamyl transpeptidase 21
calcineurin 20
CD13 20
tyrosinase 19
beta-glucuronidase 19
ERK 19
MMP-3 19
dipeptidyl peptidase IV 18
chondroitinase 18
beta-glucosidase 18
chondroitinase 18
alpha-lytic protease 18
glutathione reductase 17
aldolase 16
beta-lactamase 16
caspase-3 16
glutamate dehydrogenase 15
xanthine oxidase 15
PNGase F 15
alpha-mannosidase 15
glutamate dehydrogenase 15
transcriptase 15
proteinase A 15
mitogen-activated protein kinase 15
glutamate dehydrogenase 15
aspartate aminotransferase 15
chymotrypsin C 14
glyceraldehyde-3-phosphate dehydrogenase 14
guanylate cyclase 14
prostate-specific antigen 14
phosphorylase 13
granzyme B 13
phosphorylase kinase 13
alpha-L-fucosidase 13
glucoamylase 12
glyceraldehyde-3-phosphate dehydrogenase 12
sulfatase 12
dihydrofolate reductase 12
myosin light chain kinase 12
glyceraldehyde-3-phosphate dehydrogenase 12
furin 12
lipoxygenase 12
endoglycosidase H 12
transglutaminase 12
laccase 11
isoamylase 11
Streptomyces griseus protease B 11
lactase 11
deoxyribonuclease 11
deoxyribonuclease 11
chymosin 11
cathepsin C 11
glucose oxidase 11
hexokinase 11
apyrase 11
CPR 11
glutathione peroxidase 11
cellulase 11
ornithine decarboxylase 11
endoproteinase Asp-N 11
PARP 10
sialidase 10
glyceraldehyde-3-phosphate dehydrogenase 10
3C protease 10
glucose-6-phosphate dehydrogenase 10
Pla 10
caspase-1 10
micrococcal nuclease 10
Mg2+-ATPase 10
luciferase 10
NO synthase 10
glyceraldehyde-3-phosphate dehydrogenase 10
citrate synthase 10
chitinase 10
thermitase 9
alpha-galactosidase 9
more...
Compound
serine 1289
Dec 789
sodium 781
Phe 710
arginine 697
SDS 608
water 607
sulfate 600
lysine 590
alanine 521
leucine 495
tyrosine 445
DNA 443
calcium 442
cysteine 399
His 383
Trypsin 354
methionine 345
Asp 323
bromide 305
Gly 287
hydrogen 268
NH2 260
salt 248
tryptophan 238
ATP 233
phosphate 233
tryptophan 231
ammonium 227
tryptophan 223
tryptophan 223
urea 220
DEAE 219
threonine 216
Clin 215
Ile 192
acetate 177
PEG 140
glucose 136
oxygen 130
ADP 129
EDTA 126
EDTA 126
galactose 121
ethanol 118
ADP 112
ADP 111
proline 109
zinc 105
PEG 105
nitrogen 97
Mg2+ 91
Triton X-100 85
HCl 83
TOF 80
Serine 80
acrylamide 77
guanidine 76
valine 74
AMP 74
glutamic acid 72
aspartic acid 71
nitric oxide 70
aspartic acid 66
copper 66
methanol 65
aspartic acid 64
aspartic acid 64
PMSF 61
cAMP 61
potassium 60
acetone 59
glycerol 58
isoleucine 55
acetonitrile 53
isoleucine 53
acetic acid 52
asparagine 52
aldehyde 51
glutamine 51
Tris 51
iron 51
TPCK 51
GTP 49
PABA 49
glutamate 47
aldehyde 45
TCA 45
manganese 44
hydroxylamine 44
hydroxylamine 42
chloroform 41
GlcNAc 40
Thrombin 40
Tris 39
NAD 36
cGMP 36
ACS 33
2-mercaptoethanol 32
fluorine 32
silver 31
ammonia 30
iodine 29
Heparin 28
H2O2 28
formaldehyde 28
DMSO 27
Optimal 27
MCA 27
NAD 26
ACS 26
CaCl2 26
MCA 26
DTT 25
2-ethylhexyl 25
Insulin 25
GSH 25
GSH 25
alcohol dehydrogenase 25
2-ethylhexyl 25
DTT 25
2-ethylhexyl 25
MgCl2 24
formaldehyde 24
Pro-Gly 24
NADPH 23
NADPH 23
hexane 23
benzene 23
carbonate 23
octane 23
Casein 23
NADH 23
ethyl acetate 22
prostaglandin E1 22
DMF 22
CoA 21
toluene 21
cobalt 20
octyl 20
octyl 20
octyl 20
phosphorus 20
naphthalene 19
nickel 19
CO2 19
2-hydroxyethyl 18
COS 17
PAM 17
PAM 17
PMA 17
hydroxide 17
phenol 17
xylose 17
GalNAc 17
L-leucine 17
formic acid 16
NADP 16
pyridine 16
formic acid 16
more...