Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.1 (
chymotrypsin
)
10,938
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
1 Trypsin in free solution and trypsin-sepharose were shown to be inhibited by Ag+ in the absence of Cl-. 2 In the presence of Cl- and absence of a suitable carrier, Ag+ has no inhibitory action on trypsin or
chymotrypsin
. 3
Sulphadimidine
bound Ag+ in the presence of Cl-, and carried the Ag+ to both trypsin and
chymotrypsin
in free solution as well as to trypsin-sepharose leading to the inhibition of all these enzyme systems. 4 The neutral protease of tumour cell surfaces was inhibited by Ag+ transported by sulphadimidine in the presence of Cl-. 5 Kinetic data demonstrated the requirements for both Ag+ and carrier to effect inhibition, the degree of inhibition being directly related to the molarity of each of these reagents. 6 The known inhibition of trypsin by Ag+ binding to histidine in the active site has been defined in mechanistic terms employing the sulphonamide drug, sulphadimidine, to illustrate this exchange mechanism.
...
PMID:Evidence for the carriage of silver by sulphadimidine: inhibition of proteolytic enzymes. 675 52
