Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.21.1 (
chymotrypsin
)
10,938
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Supernatants from 24 hr cultures of PHA-pulsed human T lymphocytes inhibit the migration of human peripheral blood T lymphocytes and guinea pig macrophages in vitro. The factor responsible for the inhibition of T lymphocytes provisionally called
TIF
(T cell migration inhibitory factor) was separated from MIF by preparative PAGE, had apparent molecular weight (m.w.) of 1,000-10,000 daltons and isoelectric point of 3.1.
TIF
activity was resistant to treatment with trypsin,
chymotrypsin
and neuraminidase but sensitive to PMSF (phenyl-methyl-sulfonyl-fluoride). This suggests that
TIF
is presumably different from human MIF and may represent a novel lymphokine which preferentially affects T cell migration in vitro.
...
PMID:Partial purification and physicochemical properties of human T cell migration inhibitory factor (TIF). 639 62
