Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.4.21.1 (chymotrypsin)
 10,938 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the study was to examine the secretory response of the exocrine pancreas in man to various doses of the synthesised decapeptide Caerulein (Takus), 5, 10 and 20 ng/kg Caerulein injected intravenously during an infusion of 0,5 CU/kg/h Secretin (GIH) produced a linear increase of enzyme secretion (amylase, lipase, trypsin and chymotrypsin) and also an increase in the water and bicarbonate secretion of the pancreas which is induced by Secretin. The injection of 40 ng/kg Caerulein led to no further increase of the ecbolic function. The intravenous injection of 1 Ivy dog unit (IDU/kg and 20 and 40 ng/kg Caerulein have an identical effect on the exocrine pancreas, there were no statistic differences.
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PMID:[Effect of caerulein on the exocrine pancreas function in man; examinations of dose effects and comparisons with the effect of cholecystokinin/pankreozymin (author's transl)]. 49 1

In order to study the question as to whether the enzyme ratios in the pancreatic juice change with the secretion rate, we analysed the enzyme outputs of 20 healthy volunteers under combined stimulation with varying doses of cholecystokinin (0; 0.5; 1.0 or 1.3 IDU X kg-1 X h-1), administered in random order, plus a constant dose of secretin (0.5 CU X kg-1 X h-1). The outputs of the individual enzymes correlated significantly (p less than 0.0001) to the corresponding amylase outputs in the form of power model regressions. Mathematical transformation of these curvilinear regressions permitted a comparison of their courses. This analysis revealed that the enzyme ratios in the pancreatic secretion change continuously at increasing outputs in favour of lipase greater than chymotrypsin greater than amylase. The shift in the ratio of lipase to trypsin and to amylase and that of chymotrypsin to amylase was significant (p less than 0.01).
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PMID:Output-dependent non-parallel enzyme secretion of the human pancreas. 241 63

The effect of varying the intensity of pancreatic stimulation on the synthesis of human pancreatic enzymes has not previously been studied. We have measured the secretion and synthesis of pancreatic enzymes in response to either secretin alone (1 CU.kg-1.h-1) or secretion plus increasing doses of cholecystokinin (CCK) (0.25, 0.5 or 1.0 IDU.kg-1.h-1). Enzyme synthesis was measured using the incorporation of 75Se-methionine (0.15 mCi (5.6 kBq).kg-1.h-1) into the trichloracetic acid-insoluble fraction of the duodenal aspirate. Outputs of trypsin, chymotrypsin, lipase and protein showed a bell-shaped dose response to increasing doses of cholecystokinin, with maximal outputs occurring in response to secretin plus cholecystokinin 0.5 IDU.kg-1.h-1. The rate of incorporation of 75Se-methionine increased with increasing doses of cholecystokinin and was maximal in response to secretion plus cholecystokinin 1.0 IDU.kg-1.h-1. There was therefore dissociation between the secretory and synthetic responses to increasing doses of cholecystokinin.
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PMID:Dissociation between pancreatic enzyme secretory and synthetic dose-responses to cholecystokinin in man. 369 74

Sulpiride is a nonsedative neuroleptic, pharmacologically related to metoclopramide, which has previously been shown to affect various gastric functions and to exert a beneficial effect in the treatment of duodenal ulcer. In the present study the authors investigated the effects of sulpiride on pancreatic exocrine secretion. The intravenous injection of sulpiride (100 mg) during a constant infusion of secretin (0.5 CU/kg/hr) and cholecystokinin (0.5 IDU/kg/hr) significantly increased outputs of bicarbonate and enzymes in nine healthy subjects. The increase was maximal 20-30 min after sulpiride administration and lasted for the duration of the study (1 hr). Compared to presulpiride control levels, the mean maximum percent increase was 35% for bicarbonate, 39% for lipase, and 32% for chymotrypsin. It is concluded that sulpiride augments pancreatic secretion stimulated by submaximal doses of secretin and cholecystokinin. The mechanism of this effect is unknown.
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PMID:Stimulation of pancreatic secretion by sulpiride. 741 89