Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.21.1 (chymotrypsin)
 10,938 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A cDNA encoding the carboxy-terminal of the 12-kDa subunit of antigen B of Echinococcus granulosus has been cloned and sequenced. In addition, an amino acid sequence has been generated for the amino-terminal which is tentatively contiguous with the open reading frame of the DNA-derived sequence. Comparison of the inferred sequence of the 12-kDa antigen with other known sequences indicated a limited similarity to alpha-1 antitrypsin. In functional assays, gel-purified native 12-kDa antigen from natural infections inhibited elastase but not trypsin or chymotrypsin, providing further evidence that this antigen is a parasite protease inhibitor. Possibly unrelated to its anti-protease activity but a potentially important function of the 12-kDa antigen was its ability to inhibit recruitment of neutrophils. These functions may be important to the viability of the parasite in the face of the host immune response. In addition, the match between the DNA-derived sequence and the protein sequence was imperfect, with some residues having, according to the amino acid sequencing, two alternatives in approximately equal concentrations, and four DNA-derived residues failing to match with the protein sequence at all. The 12-kDa antigen may be expressed as isoforms from a polymorphic gene and, as far as aware, this observed sequence polymorphism has not, to date, been described for any other flatworm antigen.
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PMID:A protein secreted in vivo by Echinococcus granulosus inhibits elastase activity and neutrophil chemotaxis. 201 Nov 56

An inflammatory reaction protein is a protein whose rate of synthesis is greater than its rate of catabolism in the presence of an inflammatory process. This is reflected by an increase in its plasma concentration. In man, orosomucoid, alpha-1 antitrypsin, alpha-1 anti-chymotrypsin, haptoglobin, ceruloplasmin, fibrinogen and C reactive protein (CRP), all conform to this definition. The authors present the principal physicochemical properties of the proteins. However, none of these proteins, on its own, constitutes an ideal marker of inflammation. The authors also propose the use of an inflammatory miniprofile consisting of "CRP, orosomucoid and haptoglobin" to detect, quantify and follow an inflammatory reaction. The authors stress the importance of using a rapid assay technique like immunonephelemetry , which is essential for the clinical usefulness of these proteins. Finally, they discuss the process of synthesis and the biological role of these proteins.
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PMID:[Proteins of the inflammatory reaction. Definition, physiology and methods for determination]. 620 41

Primary malignant fibrous histiocytoma (MFH) of the liver remains extremely rare with only several cases having been reported in literature. We report a case of hepatic MFH in a 53-year-old man who presented with upper abdominal pain, and weight loss for one month. Ultrasound and computed tomography (CT) scan showed a large mass with fine tumor vessels over the left lobe of the liver. Histopathological findings indicated a mesenchymal tumor consisting of spindle cells in storiform pattern intermingled with histiocyte-like cells and giant cells. Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68. Morphological and immunohistochemical findings support that the tumor should be classified as a primary malignant fibrous histiocytoma. The literatures is briefly reviewed.
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PMID:Primary hepatic malignant fibrous histiocytoma: a case report and review of the literature. 1770 13