Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.17.21 (prostate-specific membrane antigen)
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Human Gene/Protein
DC43 14.1
Glutamate carboxypeptidase II 14.1
N-acetylated alpha-linked acidic dipeptidase 2 14.1
glutamate carboxypeptidase II 14.1
PSMA 14.1
prostate-specific membrane antigen 13.8
NAALADase 13.6
NAALADase II 13.6
Protein tyrosine phosphatase, receptor type, C 13.1
N-acetylated-alpha-linked-acidic dipeptidase 12.9
FOLH1 12.8
40S ribosomal protein S16 12.6
NAP-5 12.6
protein tyrosine phosphatase receptor type F 12.6
60S ribosomal protein L32 12.6
prostein 12.1
4-1BB-L 12.1
RPS4Y2 12.1
MPPA 11.8
NPH2 11.8
Cytosolic serine hydroxymethyltransferase 11.6
prostate-specific transglutaminase 11.6
I100 11.2
DPYSL3 11.2
GCP 11.1
plasma glutamate carboxypeptidase 10.8
PNRC 10.7
PGLS 10.6
PSTP 10.3
DD3 10.2
mGluR3 10.2
E74-like factor 5 10.1
PRAC 10.1
PSGR 10.1
STEAP2 10.1
Tisp40 10.1
RDH11 9.9
cytosolic serine hydroxymethyltransferase 9.8
prostate stem cell antigen 9.8
GCP2 9.8
STEAP 9.7
SPRR2A 9.7
zinc metallopeptidase 9.6
Phosphoserine phosphatase 9.6
SPON2 9.5
KLK2 9.4
CDH6 9.4
prostate-specific antigen 9.4
HK3 9.3
PSM 9.3
Aspartoacylase 9.3
NCAM2 9.2
gastrin-releasing peptide receptor 9.2
GalNAc-T3 9.1
MYC-associated zinc finger protein 9.1
gastrin releasing peptide receptor 9.1
hypoxanthine phosphoribosyltransferase 1 9.0
MHC2TA 8.9
FCER1G 8.9
PSMA6 8.9
CRMP4 8.8
KLK3 8.8
kallikrein 4 8.8
TN-C 8.8
ribosomal protein S16 8.7
TARP 8.7
CTNND2 8.6
SART3 8.6
CN2 8.6
PSA 8.6
CTBP1 8.6
KLK11 8.5
AMACR 8.5
hepsin 8.5
type II integral membrane protein 8.5
reduced folate carrier 8.4
TGX 8.4
MTSS1 8.3
glioma-associated oncogene homolog 1 8.3
type II membrane protein 8.3
more...
Disease
Small cell carcinoma of prostate 13.1
recurrent prostate cancer 11.7
Bone lesion 10.7
Hereditary canine spinal muscular atrophy 10.1
Progression of prostate cancer 9.8
metastatic papillary thyroid cancer 9.6
metastatic adrenocortical carcinoma 9.0
stage IIIB NSCLC 8.9
PSA 8.6
Hurthle cell adenoma 8.6
Prostate tumor 8.5
prostate cancer 8.4
postpolio syndrome 8.3
Opioid Withdrawal 8.2
cortical thymoma 8.2
Metanephric adenoma 8.1
Chronic beryllium disease 8.0
unknown primary cancer 7.9
prostatic adenocarcinoma 7.9
high-risk cancer 7.7
Nephrogenic adenoma 7.6
prostatic disease 7.5
Lymph node metastases 7.5
Large cell neuroendocrine carcinoma 7.4
hormone refractory prostate cancer 7.4
MDK 7.4
bone marrow metastases 7.4
bone metastases 7.3
Duodenum 7.2
Duodenum 7.2
thyroid adenoma 7.1
squamous cell carcinoma of the penis 7.0
salivary gland cancer 6.8
Prostate Cancer 6.8
tropical sprue 6.8
carcinoma of the parotid 6.7
RGS 6.6
Nodular fasciitis 6.6
Fibrous dysplasia 6.6
US1 6.5
primary lateral sclerosis 6.4
BOS 6.3
neuroendocrine tumor 6.0
angiolipoma 6.0
Ductal 5.9
beryllium disease 5.9
Canavan 5.9
Adenoid cystic carcinoma 5.9
thyroid neoplasm 5.8
Brock 5.8
enthesopathy 5.7
metastatic ovarian cancer 5.7
ACV 5.7
tumor lysis syndrome 5.6
adrenal adenoma 5.5
metastases 5.5
Lowe 5.5
renal clear cell carcinoma 5.5
folate deficiency 5.4
dermatofibroma 5.4
measurable disease 5.4
xerostomia 5.4
tumor vasculature 5.2
villous adenoma 5.2
hemangiosarcoma 5.1
TOC 5.0
brain metastases 5.0
multicore 5.0
MIP 4.8
leptomeningeal metastases 4.8
primary tumor 4.7
priapism 4.7
DM1 4.7
Franklin 4.7
hemangiopericytoma 4.6
thyroid nodule 4.6
carcinomatosis 4.6
solid tumor 4.6
PIN 4.6
adenocarcinoma of the lung 4.6
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Symptom
penile lesion 8.0
Sister Mary Joseph's nodule 7.9
No pain 7.4
loin pain 5.8
eye pain 5.6
bone pain 4.9
Neuropathic pain 3.7
memory loss 3.3
nausea 2.2
acute pain 2.2
back pain 2.2
pelvic pain 2.2
exhaustion 2.0
numbness 1.8
paresis 1.6
hemoptysis 1.6
tremor 1.0
analgesia 0.9
pain 0.9
splenomegaly 0.9
dyspnea 0.4
fatigue 0.1
headache -0.6
collapse -0.7
vomiting -0.8
weakness -1.1
seizures -1.1
diarrhea -1.7
Drug
Indium In 111 capromab pendetide 14.1
ProstaScint 12.3
Butylamine 11.3
Bavituximab 11.0
Provenge 9.9
PMPA 9.9
Ferumoxytol 7.6
CDX 7.1
CDX 6.7
Ipilimumab 6.5
Zoladex 6.1
DM1 6.1
Zoladex 5.9
CTC 5.7
CTC 5.4
Maltose 5.3
Dihydro 5.1
Indocyanine green 5.0
Emodin 5.0
Docetaxel 4.9
R1881 4.8
PDL 4.8
DMSA 4.6
Albumin 4.2
TMS 4.0
PCP 3.9
CoCl2 3.9
CoCl2 3.9
Vitamin B 3.9
ETS 3.8
CTA 3.7
Bayer 3.5
TAC 3.5
Bevacizumab 3.4
NaI 3.3
NaI 3.3
NaI 3.3
NaI 3.3
ADR 3.1
uPA 3.1
DHT 3.0
DHT 3.0
L-tyrosine 2.9
ROC 2.8
THF 2.7
lysine 2.7
ENT 2.7
ABC 2.6
ADM 2.5
Asn 2.2
Gel 1.9
CAM 1.6
SiO2 1.6
nitroglycerin 1.0
IFN-gamma 0.9
Leaf 0.7
TiO2 0.7
ascorbate 0.6
IL-2 0.3
CSF 0.2
vitamin E 0.0
Enzyme
prostate-specific membrane antigen 14.1
carboxypeptidase G2 10.1
Aeromonas proteolytica aminopeptidase 10.0
prostate-specific antigen 9.4
HK3 9.3
alpha-methylacyl-CoA racemase 9.3
carboxypeptidase II 8.9
conjugase 8.8
fluorinase 8.7
hepsin 8.5
hepsin 8.5
folylpolyglutamate synthetase 8.0
MDP 8.0
carboxypeptidase S 8.0
methylenetetrahydrofolate dehydrogenase 7.4
methylenetetrahydrofolate dehydrogenase 6.9
homocysteine methyltransferase 6.8
KLK7 6.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 6.5
methionine synthase reductase 6.5
uracil phosphoribosyltransferase 6.5
amylomaltase 6.4
choline kinase 6.4
PPH 6.2
serine racemase 6.0
cytosine deaminase 5.6
aminopeptidase A 5.4
glutaminase 5.2
polo-like kinase 1 5.1
thymidylate synthase 5.1
meprin 5.0
dipeptidyl peptidase IV 5.0
MIP 4.9
branching enzyme 4.8
methylenetetrahydrofolate reductase 4.7
methylenetetrahydrofolate reductase 4.7
pullulanase 4.6
insulin-degrading enzyme 4.6
kallikrein 4.6
methionine synthase 4.4
methionine synthase 4.3
SCS 4.2
thymidine kinase 4.1
phosphoglycerate kinase 4.1
sucrase 3.9
CD10 3.9
PCP 3.9
tissue kallikrein 3.8
carboxypeptidase Y 3.8
firefly luciferase 3.7
dihydrofolate reductase 3.6
ricin 3.5
granzyme B 3.5
DTA 3.4
cathepsin K 3.3
thermolysin 3.3
DCF 3.2
cathepsin B 3.1
reverse transcriptase 3.1
chaperonin 3.1
PARP 3.0
histidine kinase 2.9
invertase 2.9
urokinase-type plasminogen activator 2.8
asparaginase 2.7
histone acetyltransferase 2.7
tryptase 2.7
glucokinase 2.7
CPT 2.5
ACS 2.5
luciferase 2.4
CPT 2.4
CD13 2.3
CaMKII 2.2
cathepsin D 2.1
MMP 2.1
acid phosphatase 2.1
ERK 2.1
glyceraldehyde-3-phosphate dehydrogenase 2.1
glyceraldehyde-3-phosphate dehydrogenase 2.0
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Compound
3-aminohexanedioic acid 14.1
pentanedioic acid 12.5
C15H15NO2 11.6
NAAG 10.6
Indicaxanthin 10.4
Butylamine 10.4
8-aminooctanoic acid 9.8
icosane 8.8
2-amino-4-phosphonobutanoic acid 8.8
2-amino-4-phosphonobutanoic acid 8.8
2-pentene 8.6
Exotoxin 8.2
DCL 7.8
3-aminobenzoic acid 7.7
Parthenolide 7.5
Parthenolide 7.3
N-acetylaspartate 7.1
Phosphonate 7.0
cysteate 7.0
LIN 6.8
1,4,7,10-tetraazacyclododecane 6.7
5,10-methenyltetrahydrofolate 6.6
Plumbagin 6.3
tetradecane 6.1
Choline 6.1
2,1,3-benzothiadiazole 6.1
Cyanine 6.1
Procainamide 6.0
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
sulfamide 5.9
sulfamide 5.9
carbonic acid 5.9
carbonic acid 5.8
Kallikrein 5.8
1H-pyrrole-2,5-dione 5.7
5-FC 5.7
2,6-diisopropylphenyl 5.7
VPM 5.6
Pyridoxine 5.6
PAP 5.5
Ornithine 5.5
MK801 5.4
PGA 5.4
carbonic acid 5.4
4-vinylpyridine 5.4
Phencyclidine 5.4
5-formyltetrahydrofolate 5.3
His-Leu 5.3
Docetaxel 5.3
PAP 5.3
PAP 5.3
Bismuth 5.3
Maltose 5.3
PAP 5.2
Glutamate 5.2
Androgen 5.1
H-3 5.1
Norfloxacin 5.1
carbonic acid 5.1
A 71 5.0
Glu-Glu 5.0
APH 5.0
protocatechuate 5.0
Memantine 4.9
glutamate 4.9
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