Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Despite advances in therapy, survival among patients with locally advanced squamous cell carcinoma of tongue (TSCC) and cervical lymph node metastasis remains dismal. Here, we estimated the functional effect of
AEG-1
on TSCC metastasis and explored the molecular mechanism by which
AEG-1
stimulates epithelial-mesenchymal transition (EMT). We initially found that
AEG-1
mRNA levels were much higher in metastatic TSCC than in non-metastatic TSCC and that
AEG-1
expression strongly correlates with EMT status. Receiver operating characteristic analysis showed that the combined
AEG-1
and EMT statuses are predictive of the survival rate among TSCC patients. In addition,
AEG-1
knockdown inhibited EMT in cultured TSCC cell lines and in a xenograft-mouse model. Recombinant
AEG-1
activated Wnt/
PCP
-Rho signaling, and its stimulatory effects on TSCC cell invasiveness and EMT were reversed by an anti-Wnt5a neutralizing antibody or by inhibition of Rac1 or ROCK. These results highlight the critical stimulatory effect of
AEG-1
on cancer cell invasiveness and EMT and indicate that
AEG-1
may be a useful prognostic biomarker for TSCC patients.
...
PMID:AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma. 2668 85
