Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The metabolism of phencyclidine (
PCP
) was examined in the isolated perfused lung (lPL), lung microsomes, and liver microsomes of rabbits. The concentration of
PCP
in the
IPL
perfusate decreased rapidly with concomitant increases in the concentrations of
PCP
metabolites. The total rate of
PCP
metabolite appearance in the perfusate of the
IPL
was 77.4 nmol/lung/min. The apparent Vmax of
PCP
metabolism by the lung and liver microsomes were 1.52 and 22.9 nmol of
PCP
metabolised per mg of microsomal protein per min, respectively. Extrapolated to the whole lung, the apparent Vmax of
PCP
metabolism by lung microsomes was equivalent to 78.6 nmol of
PCP
metabolized per lung per min, essentially the same as that for the
IPL
.
...
PMID:Rates of phencyclidine metabolism by the isolated perfused lung, lung microsomes, and liver microsomes of rabbits. 612 35
