Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Phencyclidine (
PCP
) induces a psychotomimetic state that closely resembles schizophrenia, and
PCP
-treated animals can serve as a model for schizophrenia. The effects of
PCP
on the gene expression of
NVP-1
, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the
NVP-1
mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of
PCP
-induced psychosis and, presumably, schizophrenia.
...
PMID:Delayed changes in neural visinin-like calcium-binding protein gene expression caused by acute phencyclidine administration. 874 71
