Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of the CD40-
CD40 ligand
(
CD40L
) interaction in resolution of Pneumocystis carinii (PC) pneumonia (
PCP
) was assessed in a PC-infected severe combined immunodeficiency (SCID) mouse reconstitution model using an anti-
CD40L
mAb to block
CD40L
. SCID mice infected with PC were reconstituted with unfractionated spleen cells from immunocompetent donors and given either anti-
CD40L
mAb or an irrelevant control mAb. Mice given the control mAb resolved the PC infection, whereas those given the anti-
CD40L
mAb did not. That anti-
CD40L
mAb also inhibited PC-specific IgG production is consistent with the possibility that cognate CD4+ T cell-B cell interactions are important in
PCP
resolution. The experiment was then repeated, except that the PC-infected SCID mice were reconstituted with purified CD4+ T cells only. Again, the control mAb-treated group resolved the
PCP
, whereas mice treated with anti-
CD40L
mAb did not. In the second experiment, inhibition of resolution of
PCP
in the anti-
CD40L
mAb group was not the result of blocking CD4+ T cell-dependent activation of PC-specific B cells. The results are consistent with the possibility that resistance to
PCP
may involve interaction between B cells and CD4+ T cells via the CD40-
CD40L
pathway. However, results additionally indicate that inhibition of CD40-
CD40L
interaction ablates resistance to
PCP
by inhibiting the interaction of T cells with some cell other than B cells.
...
PMID:CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice. 756 Oct 48
