Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A specific protein termed as
PCP
accumulates in the newly synthesized pupal cuticle of the silkworm, Bombyx mori. We have cloned the genomic sequence encoding
PCP
and analyzed its structure. The
PCP
gene comprises two exons interspersed by a single intron approx. 5.8 kb in length. Transcription initiation sites of the
PCP
gene were located at nucleotide level. The 5' flanking region of the gene contains a sequence homologous to the
Pit-1
DNA recognition element of the rat prolactin and growth hormone genes. The developmental profile of the
PCP
precursor RNA in epidermal cells showed that the biosynthesis of
PCP
is regulated at the transcriptional level in a stage- and tissue-specific fashion during post-embryonic development. Administration of 20-hydroxyecdysone to the isolated abdomens prepared from the early fifth instar larvae provoked the accumulation of
PCP
mRNA in epidermis, suggesting that the molting hormone triggers the expression of
PCP
gene.
...
PMID:Structure and expression of gene coding for a pupal cuticle protein of Bombyx mori. 139 Aug 88
