Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phencyclidine (PCP) is an illicit drug with a high potential for negative effects. It is easy to synthesize and difficult to control because the precursors are easy to obtain. DAWN data shows that PCP episodes in emergency rooms and hospitals have increased from the twenty-third most frequently observed drug in 1973 to sixteenth in 1975. One explanation for the increase in PCP use is the change in the mode of administration from pill to smoking. An exploratory study of a local outbreak of PCP describes the effects of PCP and the dilemma facing the user. Regular PCP use is difficult to hide, but since stigma is attached to PCP use, the PCP user is reluctant to admit to regular use.
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PMID:Phencyclidine (PCP): a local and national perspective. 61 89

A procedure is described for removing most of the GDP bound at the exchangeable GTP binding site (E site) of tubulin. Microtubule protein containing substoichiometric amounts of GDP at the E site is found to polymerize in response to: (a) two nonhydrolyzable ATP analogues, adenylyl imidodiphosphate (AMP-PNP) and adenylyl beta, gamma-methylenediphosphonate (AMP-PCP); and (b) substoichiometric levels of GTP or dGTP. The results are interpreted as suggesting that: (1) when GDP is removed from tubulin, the E site shows broad specificity for nucleoside triphosphates: (2) microtubule assembly can be induced by the binding of substoichiometric amounts of nucleoside triphosphate to the E site.
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PMID:Nucleotide specificity in microtubule assembly in vitro. 62 42

Phencyclidine (PCP) is a dissociative veterinary anesthetic and tranquilizer that at present is being abused as a psychedelic and hallucinogenic agent with increasing frequency. The cases of two young patients suffering from phencyclidine toxicity are reported. In each, central nervous system depression was accompanied by an acute dystonic motor reaction resulting in acute rhabdomyolysis and myoglobinuria. Skeletal muscle injury was felt to be the result of excessive involuntary isometrimc motor activity rather than a direct effect of phencyclidine on skeletal muscle. Patients suffering from phencyclidine intoxication should be screened for acute rhabdomyolysis. Phencyclidine intoxication should be included in the differential of nontraumatic rhabdomyolysis and should be considered among the potential causes of acute myoglobinuric renal failure.
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PMID:Phencyclidine-associated acute rhabdomyolysis. 62 51

A 23-year old white man presented an acute PCP intoxication. His EEG showed a monomorphic nonreactive generalized theta rhythm which is the typical activity of PCP overdose. This background was interrupted by periodic bilaterally synchronous high voltage slow paroxysms similar to those described in subacute sclerosing panencephalitis. This unusual finding supports the hypothesis that PCP may act by reversible deafferentation of cortical neurons.
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PMID:Pseudoperiodic bilateral EEG paroxysms in a case of phencyclidine intoxication. 65 79

In 15 patients hospitalized with phencyclidine (PCP) psychosis, several measures of psychopathology were examined in relationship to urine PCP levels, duration of hospitalization and mode of intoxication. Duration of hospitalization was found to be significantly shorter for smokers than for ingesters of PCP. Impaired ability to estimate 30 seconds duration was found to correlate significantly with a higher urine PCP level and a longer hospitalization. No other measure of psychopathology was found to correlate with either duration of hospitalization or urine PCP levels, now were other measures of psychopathology found to distinguish these patients from patients with acute functional mental illness.
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PMID:Acute phencyclidine (PCP) intoxication: psychopathology and prognosis. 68 4

Designed to assess the effects of Marine recruits' participation in the Physical Conditioning Platoon during 1975 (N - 635). Comparisons (t-values) of pre and post measures of an attitude questionnaire, the Comrey Personality Scales, and a self-evaluation scale indicated that significant increases in favorability of perceptions occurred during training for 12 of the 13 scales. During a stay of approximately 30 days, overweight recruits lost an average of 26 pounds. The most powerful predictors of graduation from PCP and recruit training included the Affiliation (with the Marine Corps) scale and a composite of 10 Activity Scale items. These two variables may be useful in selection of PCP participants by reducing the 36% PCP attrition rate.
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PMID:Effects of participation in the Physical Conditioning Platoon. 68 16

In fifteen patients hospitalized with phencyclidine (PCP) psychosis, several measures of psychopathology, including those of time distorsion, were examined in relationship to urine PCP levels and duration of hsopitalization. Impaired ability to estimate thirty seconds duration was found to correlate significantly with a higher urine PCP level and a longer hospitalization, the test for ability to estimate thirty seconds may be useful in clinical management of patients with PCP psychosis particularly when there is no urine PCP level available.
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PMID:Time distortion in acute phencyclidine (PCP) psychosis. A correlation between 30 seconds estimation and urine drugs levels. 71 Mar 64

Previous reports suggesting that the behavioral response of the guinea pig to phencyclidine (PCP) administration is more similar to the effects of PCP observed in higher animals than those observed in mice and rats prompted us to investigate the effects of PC on spontaneous motor activity and brain biogenic amine levels in the guinea pig. Doses of 2.5 and 5.0 mg/kg PCP were found to significantly elevate spontaneous motor activity; however, 7.5 mg/kg PCP produced highly variable results which were not significantly different from control. The concentrations of tryptophan, serotonin, 5-hydroxyindoleacetic acid, and norepinephrine were measured in the forebrain and hindbrain of previously drug naive animals 30 min after administration of 5 mg/kg PCP. As compared to saline injected control animals, PCP was observed to have no effect on any of the neurochemical determinants measured. Contrary to previous reports, these data suggest that PCP produces behavioral effects in the guinea pig which are not unlike those observed in mice and rats. Furthermore, the effects which we report on spontaneous motor activity are not related to changes in the regional concentration of any of the neurochemical variables which were measured.
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PMID:Phencyclidine: effects on motor activity and brain biogenic amines in the guinea pig. 73 43

Concentrations of phencyclidine in blood and liver are presented in five fatal cases occurring in Los Angeles County in 1976. Eleven other deaths in which phencyclidine contributed to death are described; acute psychotic reactions were observed in some of these cases. Two cases involved the drowning of individuals whose swimming capabilities may have been diminished from the effects of PCP. One case is presented in which a 20-year-old male took a massive overdose of phencyclidine for suicidal purposes.
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PMID:Phencyclidine-related deaths in Los Angeles County, 1976. 74 79

Little data exists relative to ongoing treatment of adolescent phencyclidine (PCP) abusers. This paper presents data gathered on a cohort of 87 residents in an adolescent social rehabilitation program. Approximately 50% of this cohort were either chronic or occasional PCP users. Both groups were found to be regular users of other drugs. Demographic characteristics are described, as are behaviors and symptoms reflective of various emotional and behavioral problems. When length of stay on non-PCP users and occasional and chronic users were compared, it was found that chronic users remain in treatment longest. No PCP-induced psychosis was found. Symptoms of depression, anxiety, aggitation, and other reported psychological effects of PCP were seen. Considerations for treatment are briefly discussed.
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PMID:Treatment of adolescent phencyclidine (PCP) abusers. 75 80


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