Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An update is presented on some of the treatment developments for opportunistic infections (OIs) associated with HIV infection. Treatments discussed include clarithromycin and clofazimine for treatment of mycobacterium avium complex (MAC), azithromycin for prevention of MAC, fluconazole for prevention of fungal infections, MSL109 for treatment of cytomegalovirus retinitis, and two new approaches for the treatment of Kaposi's sarcoma. Azithromycin's positive role in preventing PCP provides evidence of new directions in multiple OI prevention approaches.
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PMID:Opportunistic infections update. 1136 99

Azithromycin (Zithromax) has been used to treat a number of infections, including mycobacterium avium complex (MAC). A study using Azithromycin to prevent MAC shows the drug's effectiveness in reducing the outbreak of MAC and also protecting from other infections, including PCP. This study involved 180 HIV-positive subjects, of which 89 received 1200 mg of Azithromycin once a week, and 91 received a placebo once a week. Fifteen percent of the treated subjects developed MAC infections compared to 30 percent of the placebo group. In addition, more subjects taking the placebo developed PCP than subjects taking the Azithromycin. Diarrhea, nausea, and abdominal pain were the most common side effects from Azithromycin.
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PMID:Azithro once a week for MAC. 1136 25