Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The binding of neuropeptide Y (NPY) and
peptide YY
(
PYY
) to sigma and phencyclidine (
PCP
) receptors in brain membranes was studied. NPY and
PYY
at up to 500 nM did not bind to sigma or
PCP
receptors under different binding conditions including different temperatures, membrane preparations, protease inhibitor and sources of the peptides. These findings are in contrast with the reported potent affinities of NPY and
PYY
for sigma and
PCP
receptors by Roman et al. (1989, European J. Pharmacol. 174, 301).
...
PMID:Neuropeptide Y and peptide YY do not bind to brain sigma and phencyclidine binding sites. 164 26
Neuropeptide Y (NPY) and
peptide YY
(
PYY
) are known to bind with high affinity to sigma (sigma) and phencyclidine (
PCP
) binding sites in rat brain. The functional significance of these results was assessed by testing both peptides in an in vitro bioassay system used for studying the N-methyl-D-aspartate (NMDA) receptor and consisting of rat hippocampal slices preloaded with [3H]noradrenaline (NA) and maintained under superfusion. The addition of NMDA in the superfusion medium induced an efflux of [3H]NA from the slices and the presence of NPY and
PYY
produced an enhancement of the stimulating effect. These results suggest that NPY and
PYY
could have a modulatory role at the NMDA receptor complex through an interaction with the sigma and/or
PCP
receptor.
...
PMID:N-methyl-D-aspartate receptor complex modulation by neuropeptide Y and peptide YY in rat hippocampus in vitro. 182 14
