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Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The interaction between phencyclidine (
PCP
) and its pyrolysis product, 1-phenylcyclohexene (PC), at metabolic level was evaluated in Swiss male mice (21-24 g). PC (1.1, 2.2 and 4.4 mmol/kg/day for 4 days, IP, in corn oil) treatment to mice induced the in vitro metabolism (p less than 0.05) of amidopyrine (17%),
aniline
(12%), phenacetin (62-100%), pentobarbital (20-26%),
PCP
(25-80%) and benzo[a]pyrene (81-147%) in the 9000 g liver fraction and the hepatic microsomal contents of cytochrome P-450 (18-42%). The induction of the mixed function oxygenase (MFO) system was consistent with the decreases in the concentrations of IP administered pentobarbital (0.27 mmol/kg, in saline) and
PCP
(16.4, 32.8 and 65.6 mumol/kg, in saline) in the serum, brain, liver and kidneys of PC pretreated mice. At 1 hr after the above doses of PC, the in vitro metabolism of amidopyrine,
aniline
, or phenacetin was not inhibited. However, the biotransformation of benzo[a]pyrene was inhibited by 33 to 45%. Though PC after a single dose did not alter the tissue concentrations of
PCP
, it increased the pentobarbital concentrations in the tissues studied (p less than 0.05). These results indicate that PC has a potential to induce the MFO system after the 4-day treatment. This property of PC plays an important role in the reduction of the action of
PCP
by enhancing its metabolism, thereby decreasing its tissue levels.
...
PMID:Interaction between phencyclidine and its pyrolysis product, 1-phenylcyclohexene. 322 28
Morphine elicited a dose-related increase in the duration of phencyclidine (
PCP
)-induced motor incoordination. In the open field behavioral observations, morphine enhanced the
PCP
-induced decrease in the number of ambulation and rearing. Morphine potentiated the
PCP
-induced decrease in body temperature. The LD50 of
PCP
was significantly decreased in the presence of morphine. An opiate antagonist, naloxone, antagonized the morphine-induced effects without influencing the pharmacological actions of
PCP
itself. The levels of hepatic microsomal cytochrome P-450 and cytochrome b5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment. The half-lives of
PCP
in serum and brain were increased by the concurrent administration of morphine. The ratio of the liver weight to body weight and
aniline
hydroxylase activity in hepatic microsomal fraction were decreased in the morphine-treated group compared with the control group; this is indicative of a possible reduction in the oxidative metabolism of
PCP
. The results indicate that acute administration of morphine enhances a variety of pharmacological effects of
PCP
; an inhibition of
PCP
disposition by morphine may be a mechanism involved in this process.
...
PMID:Effect of morphine on the responses to and disposition of phencyclidine in mice. I. Enhancement of phencyclidine effects by acute morphine administration. 684 96
Higher-order derivative spectrophotometry (HODS) is a very good tool for the fine-resolution of spectra and other electric signals. This method allows one to separate superimposed curves for quantitative measuring. In the following, examples are given for the estimation of pollutants in water, air and soils which demonstrate the advantages of the HODS. This also applies to difficult problems in environmental analytical chemistry. In detail, we discuss the simultaneous estimation of
aniline
and phenol in waste water, the quantitative determination of
PCP
in polluted drinking water, phenol in turbid samples, the identification of aromatic amides and phenols in air after absorption in solvents and, last but not least, the study of Ni2+ adsorbed on bentonite powder.
...
PMID:Higher-order derivative spectrophotometry in environmental analytical chemistry. 687 2
The Dreissena-Monitor is a biological early warning system for the continuous monitoring of river water quality, based on the valve movements of two groups of 42 zebra mussels (Dreissena polymorpha). Laboratory experiments with Cd,
PCP
, and 2-chloro-4-nitro-
aniline
were conducted in combination with suspended particles (a mixture of stinging nettle powder, bentonite, and quartz powder). An increase of suspended particles up to a nominal concentration of 540 mg/L within 5 min did not evoke any reactions by the mussels significantly different from normal. The distribution between water and solids was analyzed for Cd and 2-chloro-4-nitroaniline, with the result that the former quickly adsorbed to the particles, whereas the latter did not bind to the particles at all. The behavior of the zebra mussels revealed that the detection of 2-chloro-4-nitro-
aniline
was not affected by the presence of suspended matter. In the cases of Cd and
PCP
, D. polymorpha was able to detect these substances when they were particle-associated at least as well or better as when they were dissolved in the water. The results are discussed with respect to the physiology of the organisms and the bioavailability of toxicants, as well as to the consequences these results may have under field conditions.
...
PMID:The influence of suspended particles on the acute toxicity of 2-chloro-4-nitro-aniline, cadmium, and pentachlorophenol on the valve movement response of the zebra mussel (Dreissena polymorpha). 1152 92
The reactions of aryl and alkylamines with the (
PCP
)Ir fragment (
PCP
= 1,3-di-tert-butylphosphinobenzene) were studied to determine the reactivities and stabilities of amine and amido hydride complexes relative to C-H activation products. Reaction of
aniline
with the (
PCP
)Ir unit generated from (
PCP
)IrH2 and norbornene resulted in the N-H oxidative addition product (PhNH)(H)Ir(
PCP
) (1a). In contrast, reaction of this fragment with ammonia gave the ammonia complex (NH3)Ir(
PCP
) (2). The amido hydride complex that would be formed by oxidative addition of ammonia, (
PCP
)Ir(NH2)(H) (1b), was generated independently by deprotonation of the ammonia complex (NH3)Ir(H)(Cl)(
PCP
) (3) with KN(SiMe3)2 at low temperature. This amido hydride complex underwent reductive elimination at room temperature to form the ammonia complex 2. Addition of CO to anilide complex 1a gave (
PCP
)Ir(PhNH)(H)(CO) (4a). Addition of CNtBu to terminal amido complex 1b formed (
PCP
)Ir(NH2)(H)(CNtBu) (4b), the first structurally characterized iridium amido hydride. Complexes 4a and 4b underwent reductive elimination of
aniline
and ammonia; parent amido complex 4b reacted faster than anilide 4a. These observations suggest distinct thermodynamics for the formation and cleavage of N-H bonds in
aniline
and ammonia. Complexes 1a, 2, 4a, and 4b were characterized by single-crystal X-ray diffraction methods.
...
PMID:Distinct thermodynamics for the formation and cleavage of N-H bonds in aniline and ammonia. Directly-observed reductive elimination of ammonia from an isolated amido hydride complex. 1459 86
