Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Vigabatrin
and (S)-4-allenylGABA (MDL 72483), two anticonvulsant GABA-T inhibitors, partially antagonize phencyclidine (
PCP
)-induced hyperactivity in mice at doses that do not affect spontaneous motor activity. The
PCP
antagonism is related to whole-brain GABA concentrations. The results indicate the potential use of GABA-T inhibitors in the therapy of
PCP
intoxications and perhaps also in the treatment of certain forms of endogenous psychoses.
...
PMID:Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations. 158 40
