Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The metabolism of 1-(1-phenylcyclohexyl)-piperidine (phencyclidine or
PCP
) by liver preparations from cat, monkey, rabbit and rat has been studied. 4-Phenyl-4-piperidinocyclohexanol (I), 1-1-phenylcyclohexyl-4-hydroxy-piperidine (II), N-(5-hydroxypentyl)-1-phenylcyclohexylamine (IX) and 5-(1-phenylcyclohexylamino)-valeric acid (X) were found in all species, but liver preparations of rat and rabbit were much more active than those of cat or monkey in metabolizing
PCP
. Only rabbit produced 4-(4'-hydroxypiperidino)-
4-phenylcyclohexanol
(III) in amounts detectable by g.l.c. Mass balance calculations of
PCP
, I, II, III, IX and X in the cat, monkey and rat indicate that other metabolic pathways not measured in this study are operative.
...
PMID:Species differences in the in vitro metabolism of phencyclidine. 647 6
A GLC assay for phencyclidine (
PCP
) is described, which also simultaneously measures three primary hydroxylated metabolites formed from incubating
PCP
in tissue homogenates. Using the FID detector, the limits of reliable detection of
PCP
and both monohydroxy metabolites, 4-phenyl-4-piperidino-cyclohexanol, 2, and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine, 3, are 0.02 mumol per injection and 0.05 mumol for the dihydroxy metabolite, 4-(4'-hydroxypiperidino)-
4-phenylcyclohexanol
, 2A. Baseline separation of an compounds was achieved and coefficients of variation (between-run) was 3-6% for
PCP
, and both monohydroxy metabolites, and 12% for the dihydroxy metabolite. A GCMS assay is also reported herein for the analysis of
PCP
at low levels, and can detect 5 pmol per injection of
PCP
, with a linear standard curve from 50 to 2000 pmol.
...
PMID:A gas-liquid chromatography assay for phencyclidine and its metabolites. 720 59
