Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Systemic administration of magnesium chloride was evaluated for phencyclidine (
PCP
)-like discriminative stimulus effects. Six rats were trained to discriminate
PCP
(1.25 mg/kg, i.p.) from saline under a two-lever fixed-ratio 32 schedule of food reinforcement.
Magnesium chloride
(10-80 mg/kg, i.p.) failed to substitute for
PCP
, with no dose producing greater than an average of 21%
PCP
-lever responding. At doses greater than 40 mg/kg, magnesium chloride decreased rates of responding, providing evidence that it was evaluated over a behaviorally-relevant dose range. The results provide further evidence for differences in the behavioral effects of drugs which antagonize N-methyl-D-aspartate receptor-mediated neurotransmission by different mechanisms.
...
PMID:Systemic magnesium chloride administration fails to produce phencyclidine-like discriminative stimulus effects in rats. 154 32
