Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.16.2 (
PCP
)
3,761
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of phencyclidine (
PCP
) and a number of
PCP
-like drugs on punished responding in rats were compared to those of chlordiazepoxide and morphine. Twenty rats, trained to lever-press for food reinforcement, were tested under a modified Geller-Seifter procedure using a multiple schedule with responding in one component reinforced under a fixed-interval 60-sec schedule while each response in the other component resulted in both food and brief electric shock presentation.
Chlordiazepoxide
,
PCP
, etoxadrol, (+)-N-allylnormetazocine and (-)-beta-cyclazocine all resulted in selective increases in rates of responding during the punishment component. Two drugs with predominant opiate-agonist actions in vivo, (-)-alpha-cyclazocine and morphine, did not increase punished responding at any dose tested. These results confirm previous research using pigeons that had shown antipunishment effects of
PCP
and provide further evidence for an overlap in the pharmacology of
PCP
-like drugs and depressant drugs such as barbiturates and benzodiazepines. The concordance between the discriminative stimulus properties and antipunishment effects of
PCP
-like drugs and actions at the
PCP
receptor suggests that the
PCP
receptor may play a role in both behavioral actions of this group of drugs.
...
PMID:Effects of phencyclidine-like drugs on punished behavior in rats. 253 69
