Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.16.2 (PCP)
 3,761 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 27-year-old woman, who is being successfully treated for HIV, has mostly normal results from physical examinations and feels well. Yet she had a chest X-ray that showed prominent perihilar adenopathy and a miliary pattern in all lung fields. Medical records from an open lung biopsy, photographs taken during the biopsy, and the pathology reports reveal histoplasma capsulatum infection, a rare occurrence in late-stage HIV infection, especially without concurrent symptoms including fever, wasting, cytopenias, and oral and intestinal ulcerations. It is not known whether the patient's highly active antiretroviral therapy allowed her to react to this organism as immunocompetent persons do, which is with well-formed granulomas. Her travel history was evaluated and showed that she had briefly passed through histoplasma-endemic areas of the southern United States. However, tests for histoplasma antigens returned negative, as did tests for serum histoplasma antibodies. Two immunohistochemical stainings for PCP were also both negative. The patient is being treated with Itraconazole, and may also be treated with a 3-week course of atovaquone for recurrent PCP.
 ...
PMID:An alarming x-ray in a patient who feels well. 1136 83